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  4. Recombinant Human Platelet-activating factor acetylhydrolase (PLA2G7 PAFAH)

Recombinant Human Platelet-activating factor acetylhydrolase (PLA2G7 PAFAH)

  • 中文名稱：
  • 貨號：
    CSB-YP623782HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP623782HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP623782HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP623782HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP623782HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PAFA
  • Uniprot No.：
  • 別名：
    Platelet-activating factor acetylhydrolase; PAF acetylhydrolase; EC 3.1.1.47; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase; Group-VIIA phospholipase A2; gVIIA-PLA2; LDL-associated phospholipase A2; LDL-PLA(2; PAF 2-acylhydrolase; PLA2G7 PAFAH
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress response. At the lipid-aqueous interface, hydrolyzes the ester bond of fatty acyl group attached at sn-2 position of phospholipids (phospholipase A2 activity). Specifically targets phospholipids with a short-chain fatty acyl group at sn-2 position. Can hydrolyze phospholipids with long fatty acyl chains, only if they carry oxidized functional groups. Hydrolyzes and inactivates platelet-activating factor (PAF, 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent proinflammatory signaling lipid that acts through PTAFR on various innate immune cells. Hydrolyzes oxidatively truncated phospholipids carrying an aldehyde group at omega position, preventing their accumulation in low-density lipoprotein (LDL) particles and uncontrolled proinflammatory effects. As part of high-density lipoprotein (HDL) particles, can hydrolyze phospholipids having long-chain fatty acyl hydroperoxides at sn-2 position and protect against potential accumulation of these oxylipins in the vascular wall. Catalyzes the release from membrane phospholipids of F2-isoprostanes, lipid biomarkers of cellular oxidative damage.
  • 基因功能參考文獻：
    1. The decrease of Lp-PLA2 activity in adolescents with type 2 diabetes suggests that elevated blood glucose concentrations do not have a dominant elevating effect, perhaps even a decreasing influence on Lp- PLA2 activity. PMID: 29027597
    2. Polymorphisms in rs1805017 and rs1805018, additional interaction between rs1805017 and smoking, and haplotype containing the rs1805017-H and rs1805018-T alleles were associated with increased CHD risk. PMID: 29728838
    3. CD163 positive macrophages have roles in lipoprotein-associated phospholipase A2 activity in atherosclerotic plaque PMID: 29101839
    4. evidence that Lp-PLA2 could predict all-cause mortality and rehospitalization risk among patients with ACS undergoing PCI. PMID: 29121808
    5. the relationship between two variants of apoC1 and the risk of polycystic ovary syndrome, evaluated the genotypic effects on clinical, hormonal and metabolic indexes and plasma platelet-activating factor acetylhydrolase (PAF-AH) activity, was investigated. PMID: 29636060
    6. Met117 oxidation caused enhanced flexibility and decreased compactness in oxidized state. PAF binding interaction with oxidized protein was mediated only through hydrophobic interactions. PMID: 29427679
    7. Persistently elevated serum concentrations of Lp-PLA2 were associated with an unfavorable outcome in patients with sepsis. PMID: 29138849
    8. Resveratrol downregulates Lp-PLA2 expression by inhibiting oxidative stress via SIRT1 pathway in the THP-1-derived macrophages. PMID: 28608449
    9. Elevated Lp-PLA2 mass was associated with all cause-death independently of other risk factors within one year after acute ischemic stroke. PMID: 28934604
    10. PLA2G7 and PON1 are overexpressed in prostatic neoplasm patients and can be detected early in blood. PMID: 29050675
    11. A PLA2G7 gene polymorphism determines the plasma levels of lipoprotein-associated phospholipase A2 activity and mass and manifests as a risk factor for atherosclerosis. PMID: 27905470
    12. Conclusion RBP4 may be used as a predictive factor of diabetic nephropathy patients complicated with silent cerebral infarction (SCI) and is positively correlated with cognitive dysfunction. RBP4/Lp-PLA2/Netrin-1 pathway activation may be one of the occurrence mechanisms in diabetic nephropathy complicated with SCI. PMID: 28704853
    13. Greater Lp-PLA2 activity or mass was associated with an increased risk of CHD and IS PMID: 28514697
    14. Lp-PLA2 G994T gene polymorphism may be an independent risk factor of ischemic stroke in Chinese population. PMID: 28960681
    15. Lifelong lower Lp-PLA2 activity was not associated with major risks of vascular or non-vascular diseases in Chinese adults. PMID: 27301456
    16. phospholipase A2 Group 7 (PLA2G7), to be important in regulating tumor cell migration and a novel tumor-promoting factor in nasopharyngeal carcinoma. PMID: 27487154
    17. Suggest that the plasma biomarkers Lp-PLA2 activity and mass are markers of abdominal aortic aneurysm risk after adjusting for relevant confounders. PMID: 28475940
    18. The substitution of whole grains and legumes for refined rice resulted in a reduction in Lp-PLA2 activities in plasma and PBMCs partly through improved glycemic control, increased consumption of protein relative to carbohydrate, and reduced lipid peroxides. PMID: 24904022
    19. Lipoprotein-associated phospholipase A2 and its relationship with markers of subclinical cardiovascular disease PMID: 28502488
    20. High levels of high-sensitive C-reactive protein and lipoprotein-associated phospholipase-A2 did not relate to endothelial dysfunction in ST-elevation myocardial infarction patients treated with percutaneous coronary intervention. PMID: 28110894
    21. In persistent prehypertension, increased ox-LDL hydrolysis by Lp-PLA2 enhances arterial stiffness without an age-related increase in blood pressure. PMID: 28142077
    22. LpPLA2 is found in both LDL and HDL and is distributed differently in men with T1D without any relationship to CAC score progression PMID: 27206945
    23. In a multi-ethnic cohort without baseline cardiovascular disease, higher Lp-PLA2 mass and activity were not significantly associated with an increased risk for incident peripheral arterial disease. PMID: 28215109
    24. Lipoprotein-associated phospholipase A2 as a new marker to determine cardiovascular risk in hypercholesterolemic dyslipidaemic children PMID: 27614353
    25. The simultaneous presence of the PLA2G7 279VV genotype and persistence of overweight synergistically increases the risk for hypertension. PMID: 28334001
    26. Elevated mass and activity of Lp-PLA2 related to inflammation and atherosclerosis may take part in the development of kidney injury and atherosclerosis in patients with chronic kidney disease. PMID: 27776715
    27. Taken together, these results revealed that Lp-PLA2 silencing protected against ox-LDL-induced oxidative stress and cell apoptosis via Akt/mTOR signaling pathway in human THP1 macrophages. PMID: 27392709
    28. Plasma Lp-PLA2 concentration was independently associated with coronary heart disease in Chinese patients. PMID: 28222638
    29. The distribution of V279F-AA+AC genotype and R92H-AA+AG genotype in the AP group was higher than that in the control group, whereas the Severity of Acute Pancreatitis (SAP) group and SAP with multiple organ dysfunction syndrome group distributions were higher than those in the MAP group and SAP without MODS group.G-C-A, G-A-G, and G-C-G haploids formed by A379V, V279F, and R92H may be associated with AP susceptibility PMID: 28332853
    30. results do not support added value of Lp-PLA2 for predicting cardiovascular events or mortality among CHD patients beyond traditional risk factor PMID: 27097870
    31. High Lp-PLA2 expression is associated with type 1 diabetes. PMID: 27710915
    32. This presentation aims at clarifying the involvement of Lp-PLA2 in the pathophysiology of atherosclerosis, and at assessing its interest both as a biomarker for the onset of CV events and as a therapeutic target--{REVIEW} PMID: 26499399
    33. PLA2G7 expression is significantly upregulated in human masticatory mucosa during wound healing PMID: 28005267
    34. A considerable portion of Chinese ischemic stroke patients are insensitive to aspirin treatment, which may be correlated with the MDR1 C3435T, TBXA2R (rs1131882), and PLA2G7 (rs1051931-rs7756935) polymorphisms. PMID: 27641736
    35. Uremic environment but not inflammation per se increases plasma Lp-PLA2 activity and upregulates monocytic Lp-PLA2 mRNA expression. The highest Lp-PLA2 levels were found in the classical and not in the inflammatory subsets. Atherosclerosis also contributes to a subset-specific increase in Lp-PLA2 mRNA expression. PMID: 27992874
    36. Lp-PLA2 levels in human plasma were positively associated with the severity of coronary heart disease. PMID: 27941334
    37. Greater Lp-PLA2 activity or mass was independently associated with cardiovascular events in patients with coronary heart disease, particularly in patients with stable coronary heart disease who were not receiving therapies for inhibiting Lp-PLA2.[review] PMID: 27956130
    38. Expression of LpPLA2 may be associated with obesity. Therefore, LpPLA2 mRNA expression levels may develop as an important risk predictor for vascular complications in Metabolic syndrome. PMID: 26460076
    39. PLA2G7 gene expression was co-regulated by 17-beta-estradiol and promoter methylation. PMID: 27450918
    40. no relationship with either proinflammatory cytokines or neopterin identified in Alzheimer disease PMID: 26828804
    41. Lp-PLA2 activity in Japanese men aged 50-79 years was associated significantly and positively with IMT and plaque in the carotid artery but Mendelian randomization did not support that Lp-PLA2 is a causative factor for subclinical atherosclerosis. PMID: 26775119
    42. 279Val-->Phe Polymorphism of Lp-PLA2 may lead to decrease the enzymatic activity via changes of folding kinetics and recognition to its substrate. PMID: 26595893
    43. Increased plasma Lp-PLA2 activity portends increased risk of resistant hypertension. PMID: 26801405
    44. These findings suggest that plasma PAF may be a potential biomarker for predicting poor bone health in postmenopausal women. PMID: 25501698
    45. Studied whether the level of Lp-PLA2 is associated with subclinical atherosclerosis in patients with rheumatoid arthritis. PMID: 26504820
    46. Higher Lp-PLA2 mass and activity were associated with development of both incident clinical peripheral arterial disease and low ankle brachial index. PMID: 26848158
    47. A V279F loss-of-function variant in the PLA2G7 gene resulting in 50% lower activity for each copy of the variant, is common in East Asians and associated with risk of Vascular diseases. PMID: 26791069
    48. It is assumed that Lp-PLA2 is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 itself. PMID: 25458708
    49. Cytosolic phospholipase A2 modulates TLR2 signaling in synoviocytes. PMID: 25893499
    50. Lipoprotein associated phospholipase A2 activity and apolipoprotein C3 loss-of-function variants are involved in cardiovascular disease PMID: 26117401

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  • 相關疾病：
    Platelet-activating factor acetylhydrolase deficiency (PAFAD); Asthma (ASTHMA); Atopic hypersensitivity (ATOPY)
  • 亞細胞定位：
    Secreted, extracellular space.
  • 蛋白家族：
    AB hydrolase superfamily, Lipase family
  • 組織特異性：
    Plasma. Secreted by macrophages (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 9040

    OMIM: 147050

    KEGG: hsa:7941

    STRING: 9606.ENSP00000274793

    UniGene: Hs.584823



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