在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Plakophilin-4 (PKP4), partial

  • 中文名稱:
    人PKP4重組蛋白
  • 貨號:
    CSB-YP857451HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PKP4重組蛋白
  • 貨號:
    CSB-EP857451HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PKP4重組蛋白
  • 貨號:
    CSB-EP857451HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PKP4重組蛋白
  • 貨號:
    CSB-BP857451HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PKP4重組蛋白
  • 貨號:
    CSB-MP857451HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PKP4
  • Uniprot No.:
  • 別名:
    Catenin 4; Catenin4; FLJ31261; FLJ42243; p0071; PKP 4; PKP4; PKP4_HUMAN; Plakophilin 4; Plakophilin-4; Plakophilin4
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role as a regulator of Rho activity during cytokinesis. May play a role in junctional plaques.
  • 基因功能參考文獻:
    1. p0071 is required for directional vesicle movement and secretion of different KIF3-transported carriers, thereby regulating the transport of intracellular membrane vesicles along microtubules. PMID: 28808088
    2. Data show that patients with both abnormal expression of p0071 and E-cadherin had a statistically significant shorter survival than the patients without both abnormal expression. PMID: 28898462
    3. p0071 has a key role in regulating recycling through the Rab11a-dependent perinuclear recycling compartment. PMID: 24163434
    4. This review article focuses on the functions of the p0071 protein and its closest relatives in regulating cell adhesion and cytoskeletal organization, which are critically involved in the control of cell polarity. [review] PMID: 23640939
    5. Findings suggest that aspects of folliculin tumour suppressor function are linked to interaction with p0071 and the regulation of RhoA signalling. PMID: 22965878
    6. These data support a model in which dysregulation of the FLCN-p0071 interaction leads to alterations in cell adhesion, cell polarity, and RhoA signaling. PMID: 23139756
    7. The structural and functional roles of p0071 are suggested by its preferential occurrence in distinct tubule segments, and its potential use as a cytodiagnostic cell type marker in renal pathology is discussed. PMID: 19830446
    8. ERBIN interacts in vivo with p0071 and that it may be involved in the organization of adherens junctions and the desmosomes of epithelia PMID: 12047349
    9. In addition to plakoglobin, p0071 is the second armadillo protein present in both types of adhesive junctions and may play a role in regulating crosstalk between adherens junctions and desmosomes. PMID: 12615965
    10. p0071 bound to the first 160 amino-terminal residues of desmoplakin and also interacted directly with plakoglobin, suggesting that p0071 may regulate desmosome assembly by controlling plakoglobin availability PMID: 15304078
    11. These findings support an essential role for p0071 in spatially regulating restricted Rho signalling during cytokinesis. PMID: 17115030
    12. In this review p0071 catenin, a close relative of p120 catenin, associates and regulates RhoA-GTPase at the cleavage furrow during cytokinesis. PMID: 17264675
    13. Protein p0071 has been localized as a plaque protein in adhaerens junctions of diverse epithelia and certain vascular endothelia. PMID: 19005682
    14. Data indicate that p0071 and Ect2 are transported via distinct motors and identify a novel pathway implicating KIF3 in the regulation of actin organization during cytokinesis. PMID: 19339549

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, desmosome. Cytoplasm, cytoskeleton, spindle. Midbody. Cell membrane; Peripheral membrane protein. Note=Associated with the pericentrosomal region in interphase and with spindle poles during mitosis. In anaphase, during chromosome segregation, is recruited to the central microtubule bundle, focussed at the spindle midzone and ultimately localizes to the midbody at cytokinesis. Constituent of the midbody cytoskeletal matrix. Colocalized with desmoplakin at desmosomal junctional plaques in cultured epithelial cells.
  • 蛋白家族:
    Beta-catenin family
  • 數據庫鏈接:

    HGNC: 9026

    OMIM: 604276

    KEGG: hsa:8502

    STRING: 9606.ENSP00000374409

    UniGene: Hs.407580



主站蜘蛛池模板: 国产精品igao视频| 99精品国产一区二区三区不卡| 欧美人与物videos另类| 初尝人妻少妇中文字幕| 欧美大片18禁aaa免费视频| 成人无码av网站在线观看| 亚洲天堂在线观看完整版| 欧美性潮喷xxxxx免费视频看| 亚洲成a人v影院色老汉影院| 一二三四视频社区在线播放中国| 中文字字幕在线乱码视频| 精品精品国产高清a毛片| 日韩成人极品在线内射3p蜜臀| 女人张开双腿让男人猛桶| 久久精品国产国产精品四凭| 66lu国产在线观看| 免费又黄又爽1000禁片| 亚洲另类欧美小说图片区| 国产一区二区丝袜高跟鞋| 国产乱人无码伦av在线a | 69久久国产露脸精品国产| 亚洲图片校园另激情类小说| 国产精品原创av片国产日韩| 免费大黄网站在线观| 国产白嫩护士在线播放| 中文字幕av无码专区第一页| 搡老熟女国产| 男人的天堂av网站| 18禁美女黄网站色大片免费网站 | 色综合欧美亚洲国产| 精品免费看国产一区二区| 99国产精品久久久久久久日本竹 | 国产福利日本一区二区三区| 97色精品视频在线观看| 少妇高潮喷水久久久影院| 加勒比无码人妻东京热| 制服丝袜亚洲中文欧美在线| 虎白女粉嫩尤物福利视频| 欧美性猛交xxxx富婆| 亚洲精品一区二区三区麻豆| 久久精品99久久香蕉国产|