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  4. Recombinant Human Phosphomannomutase 1 (PMM1)

Recombinant Human Phosphomannomutase 1 (PMM1)

  • 中文名稱：
    人PMM1重組蛋白
  • 貨號：
    CSB-YP018237HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PMM1重組蛋白
  • 貨號：
    CSB-EP018237HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PMM1重組蛋白
  • 貨號：
    CSB-EP018237HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PMM1重組蛋白
  • 貨號：
    CSB-BP018237HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PMM1重組蛋白
  • 貨號：
    CSB-MP018237HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PMM1
  • Uniprot No.：
  • 別名：
    Brain glucose-1,6-bisphosphatase; Phosphomannomutase 1; PMM 1; pmm1; PMM1_HUMAN; PMMH 22; PMMH-22; PMMH22; Sec53
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-262
  • 氨基酸序列
    AVTAQAARR KERVLCLFDV DGTLTPARQK IDPEVAAFLQ KLRSRVQIGV VGGSDYCKIA EQLGDGDEVI EKFDYVFAEN GTVQYKHGRL LSKQTIQNHL GEELLQDLIN FCLSYMALLR LPKKRGTFIE FRNGMLNISP IGRSCTLEER IEFSELDKKE KIREKFVEAL KTEFAGKGLR FSRGGMISFD VFPEGWDKRY CLDSLDQDSF DTIHFFGNET SPGGNDFEIF ADPRTVGHSV VSPQDTVQRC REIFFPETAH EA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
  • 基因功能參考文獻：
    1. a triple mutant of phospomannomutase1 that retains mutase and phosphatase activity, but is unable to bind inosine monophosphate, was characterized. PMID: 29261720
    2. Mutations in phosphomannomutase is associated with ophthalmic manifestations of congenital disorder of glycosylation type 1a PMID: 12789572
    3. human alpha-phosphomannomutase 1 crystallographic structure reveals the structural basis of congenital disorder of glycosylation type 1a PMID: 16540464
    4. analysis of mental development in a patient with phosphomannomutase deficiency who is compound heterozygous for T237R/C241S mutations [case report] PMID: 17186415
    5. The genes GUS and PMM1 are recommended for normalization purposes in gene expression studies of liver tissue from patients with chronic hepatitis. PMID: 18591914
    6. PMM1 is responsible for the degradation of Glc-1,6-P(2) in brain PMID: 18927083

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Eukaryotic PMM family
  • 組織特異性：
    Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 9114

    OMIM: 601786

    KEGG: hsa:5372

    STRING: 9606.ENSP00000216259

    UniGene: Hs.75835



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