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  4. PMM1 Antibody

PMM1 Antibody

  • 中文名稱：
    PMM1兔多克隆抗體
  • 貨號：
    CSB-PA018237GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    PMM1
  • 別名：
    Brain glucose-1,6-bisphosphatase antibody; Phosphomannomutase 1 antibody; PMM 1 antibody; pmm1 antibody; PMM1_HUMAN antibody; PMMH 22 antibody; PMMH-22 antibody; PMMH22 antibody; Sec53 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human PMM1
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. In addition, may be responsible for the degradation of glucose-1,6-bisphosphate in ischemic brain.
  • 基因功能參考文獻：
    1. a triple mutant of phospomannomutase1 that retains mutase and phosphatase activity, but is unable to bind inosine monophosphate, was characterized. PMID: 29261720
    2. Mutations in phosphomannomutase is associated with ophthalmic manifestations of congenital disorder of glycosylation type 1a PMID: 12789572
    3. human alpha-phosphomannomutase 1 crystallographic structure reveals the structural basis of congenital disorder of glycosylation type 1a PMID: 16540464
    4. analysis of mental development in a patient with phosphomannomutase deficiency who is compound heterozygous for T237R/C241S mutations [case report] PMID: 17186415
    5. The genes GUS and PMM1 are recommended for normalization purposes in gene expression studies of liver tissue from patients with chronic hepatitis. PMID: 18591914
    6. PMM1 is responsible for the degradation of Glc-1,6-P(2) in brain PMID: 18927083

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  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Eukaryotic PMM family
  • 組織特異性：
    Strong expression in liver, heart, brain, and pancreas; lower expression in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 9114

    OMIM: 601786

    KEGG: hsa:5372

    STRING: 9606.ENSP00000216259

    UniGene: Hs.75835



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