在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Pescadillo homolog (PES1)

In Stock
  • 中文名稱:
    人PES1重組蛋白
  • 貨號:
    CSB-EP017791HU
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    PES1
  • Uniprot No.:
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    75.4 kDa
  • 表達區域:
    1-588aa
  • 氨基酸序列
    MGGLEKKKYERGSATNYITRNKARKKLQLSLADFRRLCILKGIYPHEPKHKKKVNKGSTAARTFYLIKDIRFLLHEPIVNKFREYKVFVRKLRKAYGKSEWNTVERLKDNKPNYKLDHIIKERYPTFIDALRDLDDALSMCFLFSTFPRTGKCHVQTIQLCRRLTVEFMHYIIAARALRKVFLSIKGIYYQAEVLGQPIVWITPYAFSHDHPTDVDYRVMATFTEFYTTLLGFVNFRLYQLLNLHYPPKLEGQAQAEAKAGEGTYALDSESCMEKLAALSASLARVVVPATEEEAEVDEFPTDGEMSAQEEDRRKELEAQEKHKKLFEGLKFFLNREVPREALAFIIRSFGGEVSWDKSLCIGATYDVTDSRITHQIVDRPGQQTSVIGRCYVQPQWVFDSVNARLLLPVAEYFSGVQLPPHLSPFVTEKEGDYVPPEKLKLLALQRGEDPGNLNESEEEEEEDDNNEGDGDEEGENEEEEEDAEAGSEKEEEARLAALEEQRMEGKKPRVMAGTLKLEDKQRLAQEEESEAKRLAIMMMKKREKYLYQKIMFGKRRKIREANKLAEKRKAHDEAVRSEKKAKKARPE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.
  • 基因功能參考文獻:
    1. posttranslational modification of PES1 by SUMOylation may serve as a key factor that regulates the function of PES1 in vivo PMID: 27409667
    2. PES1 may play an important role in development of gastric cancer. PMID: 26423399
    3. PES1 may play important role in the progression of ovarian cancer by inversely regulating the ERalpha and ERbeta expression. PMID: 24376209
    4. these results uncover a potential role of PES1 in chemoresistance by regulating DNA damage response in colorectal cancer cells. PMID: 23333390
    5. Upstream of c-Jun, it was revealed that c-Jun NH2-terminal kinases (JNK) is essential for controlling PES1 expression PMID: 22860098
    6. expression of PES1 correlated positively with ERalpha expression and negatively with ERbeta expression and predicted good clinical outcome in breast cancer PMID: 22820289
    7. The physical interaction between B23 and PES1 implies that they may participate in ribosome biogenesis in a protein complex. PMID: 20011973
    8. pescadillo might play a role in promoting the proliferation and carcinogenesis of human breast cancer, and thereby might be a potential target for human breast cancer treatment. PMID: 19764998
    9. Mechanisms for the ability of Pes1 to transform cells, and its failure to immortalize them. PMID: 15273728
    10. RRB1 interacts with YPH1 (yeast pescadillo homologue 1) and other members of the Yph1 complex PMID: 15467761
    11. Pes1 and Bop1 form a stable complex with a novel member, WDR12 (PeBoW complex). PMID: 16043514
    12. Results describe the role of PeBoW-specific proteins Pes1, Bop1, and WDR12 in complex assembly and stability, nucleolar transport, and pre-ribosome association. PMID: 17353269

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Nucleus, nucleoplasm. Chromosome.
  • 蛋白家族:
    Pescadillo family
  • 組織特異性:
    Significant levels are detected in a variety of cancer cell lines, including glioblastoma, breast carcinoma, colon carcinoma and cervical carcinoma cells. Levels are abnormally elevated in malignant tumors of astrocytic origin.
  • 數據庫鏈接:

    HGNC: 8848

    OMIM: 605819

    KEGG: hsa:23481

    STRING: 9606.ENSP00000346725

    UniGene: Hs.517543



主站蜘蛛池模板: 国产多人群p刺激交换视频| 性夜影院午夜看片| 无码av免费永久免费永久专区| 精品国内综合一区二区| 免费午夜男女高清视频| 18禁止看的免费污网站| 久久综合丝袜日本网| 亚洲精品偷拍无码不卡av| 国产男生夜间福利免费网站| av片在线观看| 亚洲精品成人片在线观看精品字幕| 亚洲 欧美 日韩 综合aⅴ电影| av无码久久久久不卡网站下载| 日本免费一区二区三区视频观看| 国产又大又粗又爽的毛片| 拍拍拍无挡免费视频| 丝袜足控一区二区三区| 亚洲另类春色校园小说| 中国熟妇牲交视频免费| 国产亚洲精aa在线观看see| 国产精品美女久久久久av爽李琼 | 亚洲精品一区二区玖玖爱| 久久精品国产99精品亚洲 | 14萝自慰专用网站| 日本强好片久久久久久aaa | 军人粗大的内捧猛烈进出视频| 国产成人精品一区二三区在线观看| 久久精品免费国产大片| 国产精品亚洲综合色区| 无码av免费网站| 欧洲成人一区二区三区| 国产亚洲精品久久久久动漫| 国产av亚洲精品久久久久久小说| 人妻去按摩店被黑人按中出| 97一区二区国产好的精华液| 一区二区三区鲁丝不卡麻豆| 日韩av片无码一区二区不卡电影 | 成人免费视频在线观看| 欧美国产日韩a欧美在线观看| 已婚少妇美妙人妻系列 | 狠狠色噜噜狠狠色综合久|