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  4. Recombinant Human Paternally-expressed gene 3 protein (PEG3), partial

Recombinant Human Paternally-expressed gene 3 protein (PEG3), partial

  • 中文名稱：
    人PEG3重組蛋白
  • 貨號：
    CSB-YP867112HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PEG3重組蛋白
  • 貨號：
    CSB-EP867112HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PEG3重組蛋白
  • 貨號：
    CSB-EP867112HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PEG3重組蛋白
  • 貨號：
    CSB-BP867112HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PEG3重組蛋白
  • 貨號：
    CSB-MP867112HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PEG3
  • Uniprot No.：
  • 別名：
    PEG3; KIAA0287; ZSCAN24; Paternally-expressed gene 3 protein; Zinc finger and SCAN domain-containing protein 24
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Possesses a tumor suppressing activity in glioma cells.
  • 基因功能參考文獻：
    1. Data suggest that PEG3 is required for TFEB induction and nuclear translocation in a VEGFR2- and AMPK-dependent manner for decorin/decorin receptor-evoked autophagy. (PEG3 = paternally expressed 3 protein; TFEB = transcription factor EB; VEGFR2 = vascular endothelial growth factor receptor-2; AMPK = AMP-activated protein kinase) PMID: 28798237
    2. Peg3 transcriptionally modulates BECN1 activity. PMID: 28174297
    3. Data indicate that a set of cis-regulatory motifs and corresponding trans factors that may be critical for the transcriptional regulation of the Peg3 (Paternally Expressed Gene 3) domain. PMID: 27104590
    4. In the current study, the authors have identified three alternative promoters for mouse Peg3 and one alternative promoter for human PEG3. PMID: 27075691
    5. A resident population of resident smooth muscle progenitor cells expressing PW1 was identified in pulmonary hypertension-associated vascular remodeling. PMID: 26838788
    6. PW1/Peg3 function is essential for conferring proper mesoangioblast competence and it's level in human mesoangioblasts may serve as a biomarker to identify donor populations for therapeutic application in muscular dystrophies. PMID: 25751651
    7. The PEG3-SCAN domain appears to constitute an assembly block, enabling PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion. PMID: 23936039
    8. Genetic translocations involving PEG3 gene is associated with mesenchymal hamartoma of the liver. PMID: 24120702
    9. we have unveiled a mechanism for a secreted proteoglycan in inducing Peg3, a master regulator of macroautophagy in endothelial cells PMID: 23798385
    10. Results show that a five percent increase in DNA methylation of PEG3 is associated with a 1.6-fold increase invasive cervical cancer (ICC) risk. PMID: 23418553
    11. None of the folate cycle genotypes in the mother or infant were related to the methylation of IGF2, PEG3, or LINE-1. PMID: 23151531
    12. PEG3 gene is imprinted, with preferential expression from the paternal allele in human placenta. PMID: 11331620
    13. mammalian imprinting utilizes Peg3/Pw1 to co-opt the Wnt pathway, thereby regulating development and glioma growth PMID: 20064927
    14. Peg3/Pw1 is a mediator between p53 and Bax in DNA damage-induced neuronal death PMID: 11943780
    15. These results support a model in which pEg3 contributes to the control of progression through mitosis by phosphorylation of the CDC25 phosphatases. PMID: 15908796
    16. Loss of PEG3 expression may be a frequent event in gynecologic cancers. Given the known role of PEG3 in p53-mediated apoptosis, it is possible that PEG3 functions as a tumor suppressor. PMID: 16023706
    17. These results suggest that pEg3 might play a role at the cell cortex during mitosis. PMID: 16159311
    18. Down-regulation of PEG3 due to loss of heterozygosity and promoter methylation is associated with ovarian cancers PMID: 18286529
    19. abnormal regulation of PEG3 is associated with several glioma subtypes and that it plays an important role in tumorigenesis. PMID: 19367087
    20. PEG3 imprinted domain of humans, cows, and mice contains differing numbers of differentially methylated regions (DMR), but the PEG3-CpG island is the only DMR that is conserved among these three species. PMID: 19397955

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  • 亞細胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性：
    Brain, glial cells, astrocytes, embryo, placenta, testis, ovary and uterus. In the placenta it is found in the layer of villous cytotrophoblast cells while in the ovary it is found in the cells of the ovarian stroma including the thecal layers around the
  • 數據庫鏈接：

    HGNC: 8826

    OMIM: 601483

    KEGG: hsa:5178

    STRING: 9606.ENSP00000326581

    UniGene: Hs.731875



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