在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Paired amphipathic helix protein Sin3b (SIN3B), partial

Recombinant Human Paired amphipathic helix protein Sin3b (SIN3B), partial

  • 中文名稱：
    人SIN3B重組蛋白
  • 貨號：
    CSB-YP021328HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SIN3B重組蛋白
  • 貨號：
    CSB-EP021328HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SIN3B重組蛋白
  • 貨號：
    CSB-EP021328HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SIN3B重組蛋白
  • 貨號：
    CSB-BP021328HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SIN3B重組蛋白
  • 貨號：
    CSB-MP021328HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SIN3B
  • Uniprot No.：
  • 別名：
    SIN3B; KIAA0700; Paired amphipathic helix protein Sin3b; Histone deacetylase complex subunit Sin3b; Transcriptional corepressor Sin3b
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
  • 基因功能參考文獻：
    1. High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer. PMID: 27780928
    2. Low SIN3B expression is associated with Prostate Cancer Progression. PMID: 28807943
    3. these results suggest that stress-induced Sin3B activation is p53-dependent and is essential for p53-mediated repression of its selective target genes. PMID: 26181367
    4. The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners. PMID: 25869359
    5. A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc. PMID: 24951594
    6. this study highlights an essential role for Sin3B in IFN-c induced COL1A2 repression in smooth muscle cells. PMID: 24709079
    7. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression PMID: 24691445
    8. the essential role of Sin3B as an important associate of p53 in mediating the cellular responses to stress and in the transcriptional repression of genes PMID: 22028823
    9. identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 PMID: 21041482
    10. disruption of the function of a specific Sin3A/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells PMID: 20547842
    11. SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex PMID: 16166625
    12. The interaction between SIN3B and ETO required an intact amino-terminus of ETO and the NHR2 domain. PMID: 18205948
    13. ETO family member-mediated oligomerization and repression can be distinct events and that interaction between ETO family members and hSIN3B or N-CoR may not necessarily strengthen transcriptional repression. PMID: 18586123
    14. Modulation of Sin3B-associated activities may represent new therapeutic opportunities for treatment of cancers. PMID: 19654306

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 19354

    OMIM: 607777

    KEGG: hsa:23309

    STRING: 9606.ENSP00000369131

    UniGene: Hs.13999



主站蜘蛛池模板： 成人爽a毛片免费啪啪| 影视先锋男人无码在线| 国产又色又爽又刺激在线播放 | 国产xxxx做受性欧美88| 中文字幕aav| 午夜伦费影视在线观看| 67194熟妇在线观看线路| 亚洲s码欧洲m码国产av| 男插女高潮一区二区| 中日韩产精品1卡二卡三卡| 成人精品视频99在线观看免费| 国产精品香港三级国产av| 亚洲精品无码高潮喷水a片软| 亚洲精品久久午夜麻豆| 色五月激情五月| 韩国三级hd中文字幕| 日韩av无码一区二区三区无码 | 久久av无码αv高潮αv喷吹| 无码人妻丰满熟妇区五十路| 色偷偷亚洲精品一区二区| 国产成人无码短视频| 天天综合网网欲色| 粉嫩被粗大进进出出视频| 国产成人精品免费视频大全软件 | 国产精品成人av片免费看| 成av人片在线观看www| 在线人成免费视频69国产| 久久精品亚洲中文字幕无码网站 | 在线精品视频一区二区三区| 国产欧美综合一区二区三区| 国内熟妇人妻色在线视频 | 蜜臀av性久久久久蜜臀aⅴ麻豆| 亚洲日韩中文无码久久| 人妻系列av无码专区| 久久久橹橹橹久久久久| 天天爽夜夜爽人人爽一区二区| 久久久精品久久久久久96| 在线观看无码av网站永久免费| 日本真人做爰免费视频120秒| 国产精品videossex久久发布 | 99热99这里只有高清国产|