在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SIN3B Antibody

SIN3B Antibody

  • 中文名稱：
    SIN3B兔多克隆抗體
  • 貨號：
    CSB-PA021328LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA021328LA01HU diluted at 1:400 and staining in paraffin-embedded human tonsil tissue performed on a Leica BondTM system.
    • Immunofluorescence staining of Hela cells with CSB-PA021328LA01HU at 1:133, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) SIN3B Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SIN3B
  • 別名：
    SIN3B antibody; KIAA0700 antibody; Paired amphipathic helix protein Sin3b antibody; Histone deacetylase complex subunit Sin3b antibody; Transcriptional corepressor Sin3b antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Paired amphipathic helix protein Sin3b protein (705-769AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，SIN3B Antibody (CSB-PA021328LA01HU)，的標(biāo)記方式是Non-conjugated。對于SIN3B Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA021328LB01HU SIN3B Antibody, HRP conjugated ELISA
    FITC CSB-PA021328LC01HU SIN3B Antibody, FITC conjugated
    Biotin CSB-PA021328LD01HU SIN3B Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a transcriptional repressor. Interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. Also forms a complex with FOXK1 which represses transcription. With FOXK1, regulates cell cycle progression probably by repressing cell cycle inhibitor genes expression.
  • 基因功能參考文獻(xiàn)：
    1. High mRNA expression of SIN3A/low mRNA expression of SIN3B correlates with longer relapse free survival specifically in patients with triple negative breast cancer. PMID: 27780928
    2. Low SIN3B expression is associated with Prostate Cancer Progression. PMID: 28807943
    3. these results suggest that stress-induced Sin3B activation is p53-dependent and is essential for p53-mediated repression of its selective target genes. PMID: 26181367
    4. The study suggests that the difference in the conformation of native state structure or structural flexibility of the paired amphi pathic helices (PAH) domains of Sin3B might be responsible for interacting with specific binding partners. PMID: 25869359
    5. A conserved Myc region (amino acids 186-203) is required for the interaction with Sin3 proteins. Histone deacetylase 1 is recruited to Myc-Sin3b complexes, and its deacetylase activity is required for the effects of Sin3b on Myc. PMID: 24951594
    6. this study highlights an essential role for Sin3B in IFN-c induced COL1A2 repression in smooth muscle cells. PMID: 24709079
    7. Senescence-associated SIN3B promotes inflammation and pancreatic cancer progression PMID: 24691445
    8. the essential role of Sin3B as an important associate of p53 in mediating the cellular responses to stress and in the transcriptional repression of genes PMID: 22028823
    9. identification of a mammalian complex containing the corepressor Sin3B, the histone deacetylase HDAC1, Mrg15, and the PHD finger-containing Pf1 PMID: 21041482
    10. disruption of the function of a specific Sin3A/B domain leads to epigenetic reprogramming and derepression of specific subsets of genes in breast cancer cells PMID: 20547842
    11. SMAR1 regulates cyclin D1 by modification of chromatin through the SIN3/histone deacetylase 1 complex PMID: 16166625
    12. The interaction between SIN3B and ETO required an intact amino-terminus of ETO and the NHR2 domain. PMID: 18205948
    13. ETO family member-mediated oligomerization and repression can be distinct events and that interaction between ETO family members and hSIN3B or N-CoR may not necessarily strengthen transcriptional repression. PMID: 18586123
    14. Modulation of Sin3B-associated activities may represent new therapeutic opportunities for treatment of cancers. PMID: 19654306

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 19354

    OMIM: 607777

    KEGG: hsa:23309

    STRING: 9606.ENSP00000369131

    UniGene: Hs.13999



主站蜘蛛池模板： 欧美人与性动交ccoo| 特级a欧美做爰片第一次| 亚洲一卡2卡三卡4卡无卡下载| 俺去俺来也www色官网| 亚洲欧美成aⅴ人在线观看| 国产999精品久久久久久| 亚洲乱码一区二三四区ava| 亚洲色婷婷婷婷五月基地 | 乱精品一区字幕二区| 欧美国产精品日韩在线| 婷婷久久综合九色综合绿巨人| 内射小寡妇无码| 131mm少妇做爰视频| 国产精品18久久久久久麻辣| 青草影院内射中出高潮-百度| 97se狼狼狼狼狼亚洲网| 国产全是老熟女太爽了| 一本色道久久综合无码人妻| 六月丁香婷婷色狠狠久久| 黑人强伦姧人妻久久| 国产精品二区一区二区aⅴ污介绍| 国产色视频一区二区三区qq号| 日韩人妻熟女中文字幕a美景之屋| 青青青草国产线观| 人妻.中文字幕无码| 无码人妻丰满熟妇区96| 国产免国产免‘费| 久久久久久久岛国免费观看| 丰满无码人妻热妇无码区| 夜夜躁狠狠躁日日躁| 欧美性猛交xxxx富婆| 狠狠躁夜夜躁人人爽天天bl| 欧美搡bbbbb搡bbbbb| 久久一日本道色综合久久| 538prom精品视频在线播放| 成人无码α片在线观看不卡| 极品人妻videosss人妻| 亚洲国产精品特色大片观看完整版 | 婷婷丁香五月中文字幕| 中文字幕人妻少妇引诱隔壁| 色avav色av爱avav亚洲色拍|