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  4. Recombinant Human PDZ domain-containing protein GIPC1 (GIPC1)

Recombinant Human PDZ domain-containing protein GIPC1 (GIPC1)

  • 中文名稱：
    人GIPC1重組蛋白
  • 貨號：
    CSB-YP009435HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人GIPC1重組蛋白
  • 貨號：
    CSB-EP009435HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人GIPC1重組蛋白
  • 貨號：
    CSB-EP009435HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人GIPC1重組蛋白
  • 貨號：
    CSB-BP009435HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人GIPC1重組蛋白
  • 貨號：
    CSB-MP009435HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    GIPC1
  • Uniprot No.：
  • 別名：
    GIPC1; C19orf3; GIPC; RGS19IP1PDZ domain-containing protein GIPC1; GAIP C-terminus-interacting protein; RGS-GAIP-interacting protein; RGS19-interacting protein 1; Synectin; Tax interaction protein 2; TIP-2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-333
  • 氨基酸序列
    MPLGLGRRKK APPLVENEEA EPGRGGLGVG EPGPLGGGGS GGPQMGLPPP PPALRPRLVF HTQLAHGSPT GRIEGFTNVK ELYGKIAEAF RLPTAEVMFC TLNTHKVDMD KLLGGQIGLE DFIFAHVKGQ RKEVEVFKSE DALGLTITDN GAGYAFIKRI KEGSVIDHIH LISVGDMIEA INGQSLLGCR HYEVARLLKE LPRGRTFTLK LTEPRKAFDM ISQRSAGGRP GSGPQLGTGR GTLRLRSRGP ATVEDLPSAF EEKAIEKVDD LLESYMGIRD TELAATMVEL GKDKRNPDEL AEALDERLGD FAFPDEFVFD VWGAIGDAKV GRY
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May be involved in G protein-linked signaling.
  • 基因功能參考文獻：
    1. Upregulated expression of GIPC1 is associated with glioma. PMID: 27481513
    2. Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs. PMID: 26787837
    3. The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment. PMID: 26757732
    4. GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells. PMID: 25469510
    5. GIPC binds LPA(1) and promotes its trafficking from APPL-containing signaling endosomes to EEA1 early endosomes and thus attenuates LPA-mediated Akt signaling from APPL endosomes. PMID: 23145131
    6. Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer. PMID: 23128896
    7. a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis PMID: 22593212
    8. The placental lectins reduced the binding of IGF-I to IGF-1 receptor in a dose-dependent manner. PMID: 22082268
    9. Knockdown of ADRM1 in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK RNA and protein PMID: 21432940
    10. GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells PMID: 21209904
    11. interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
    12. aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP PMID: 21247498
    13. Findings show the importance of GIPC in breast tumor progression. PMID: 21047775
    14. GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion. PMID: 20634288
    15. Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1. PMID: 20091192
    16. Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2. PMID: 19855435
    17. The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits. PMID: 11852236
    18. expression of human GIPC1 mRNA in normal tissues, cancer cell lines, and primary tumors PMID: 11956658
    19. GIPC can regulate beta1-adrenergic receptor-stimulated, Gi-mediated, ERK activation while having no effect on receptor internalization or Gs-mediated cAMP signaling PMID: 12724327
    20. responsible for the recycling of the hormone that is internalized by the lutropin receptor and also for maintaining a relatively constant level of lutropin receptor at the cell surface during hormone internalization PMID: 14507927
    21. results support the notion that human papillomavirus type 18 E6 protein renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC PMID: 15767424
    22. These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I. PMID: 16225848
    23. GIPC can bind to itself and that the PDZ domain is involved in GIPC-GIPC interaction PMID: 16962991
    24. Targeting GIPC could be a promising new treatment option for pancreatic cancer. PMID: 18314626
    25. GIPC1 protein is overexpressed in ovarian and breast cancer PMID: 18721484
    26. GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer PMID: 18721486
    27. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC PMID: 18775991
    28. the C-terminal PDZ-binding motif of Glut1 plays a key role in growth factor regulation of glucose uptake by both allowing GIPC to promote Glut1 trafficking to the cell surface and protecting intracellular Glut1 from lysosomal degradation. PMID: 19016655

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  • 亞細胞定位：
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族：
    GIPC family
  • 組織特異性：
    Widely expressed. Expressed in skeletal muscle (at protein level).
  • 數據庫鏈接：

    HGNC: 1226

    OMIM: 605072

    KEGG: hsa:10755

    STRING: 9606.ENSP00000340698

    UniGene: Hs.655012



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