在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

GIPC1 Antibody, Biotin conjugated

  • 中文名稱:
    GIPC1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA009435LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) GIPC1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    GIPC1
  • 別名:
    GIPC1 antibody; C19orf3 antibody; GIPC antibody; RGS19IP1PDZ domain-containing protein GIPC1 antibody; GAIP C-terminus-interacting protein antibody; RGS-GAIP-interacting protein antibody; RGS19-interacting protein 1 antibody; Synectin antibody; Tax interaction protein 2 antibody; TIP-2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human PDZ domain-containing protein GIPC1 protein (7-74AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be involved in G protein-linked signaling.
  • 基因功能參考文獻:
    1. Upregulated expression of GIPC1 is associated with glioma. PMID: 27481513
    2. Drd3 palmitoylation acts as a molecular switch for Drd3-biased signaling via a GIPC1-dependent route, which is likely to affect the mode of action of antipsychotic drugs. PMID: 26787837
    3. The composite biomarker, CAPG and GIPC1 in primary breast tumors, predicted disease outcomes and benefit from zoledronate and may facilitate patient selection for adjuvant bisphosphonate treatment. PMID: 26757732
    4. GIPC status determines the loading of cellular cargo in the exosome in pancreatic cancer cells. PMID: 25469510
    5. GIPC binds LPA(1) and promotes its trafficking from APPL-containing signaling endosomes to EEA1 early endosomes and thus attenuates LPA-mediated Akt signaling from APPL endosomes. PMID: 23145131
    6. Our results do not show a predictive or prognostic function of GIPC1/Synectin expression for the outcome of radiotherapy in prostate cancer. PMID: 23128896
    7. a novel non-Smad function for endoglin and GIPC in regulating endothelial cell function during angiogenesis PMID: 22593212
    8. The placental lectins reduced the binding of IGF-I to IGF-1 receptor in a dose-dependent manner. PMID: 22082268
    9. Knockdown of ADRM1 in amplified ovarian cell-line OAW42 results in downregulation of growth factor GIPC1 and upregulation of tumor-suppressor RECK RNA and protein PMID: 21432940
    10. GIPC1 plays an essential role in oncogenic transformation, and its expression is necessary for the survival of human breast and colorectal cancer cells PMID: 21209904
    11. interactions between TRP1-GIPC and GIPC-APPL-AKT provide a potential link between melanogenesis and PI3 kinase signaling PMID: 21291857
    12. aim was to evaluate associations with albuminuria of six GLUT1 single nucleotide polymorphisms(SNPs), particularly XbaI and the previously associated Enhancer-2 (Enh2) SNP PMID: 21247498
    13. Findings show the importance of GIPC in breast tumor progression. PMID: 21047775
    14. GIPC1-MyoGEF complex formation plays an important role in regulating MDA-MB-231 breast cancer cell polarization and invasion. PMID: 20634288
    15. Among several HBc-interacting partners selected, it interacted most strongly with the human protein GIPC1. PMID: 20091192
    16. Data show that downregulation of myosin VI expression results in a significant reduction in PSA and VEGF secretion in LNCaP cells, and the intracellular targeting seems to involve myosin VI-interacting proteins, GIPC and LMTK2 and Dab2. PMID: 19855435
    17. The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits. PMID: 11852236
    18. expression of human GIPC1 mRNA in normal tissues, cancer cell lines, and primary tumors PMID: 11956658
    19. GIPC can regulate beta1-adrenergic receptor-stimulated, Gi-mediated, ERK activation while having no effect on receptor internalization or Gs-mediated cAMP signaling PMID: 12724327
    20. responsible for the recycling of the hormone that is internalized by the lutropin receptor and also for maintaining a relatively constant level of lutropin receptor at the cell surface during hormone internalization PMID: 14507927
    21. results support the notion that human papillomavirus type 18 E6 protein renders cells less sensitive to the cytostatic effect of TGF-beta by lowering the intracellular amount of TIP-2/GIPC PMID: 15767424
    22. These results suggest that caveolae could represent an intracellular site that contributes to differentiate IR and IGF-IR activity, and demonstrate the role of caveolin-1 in the eNOS activation by Insulin and IGF-I. PMID: 16225848
    23. GIPC can bind to itself and that the PDZ domain is involved in GIPC-GIPC interaction PMID: 16962991
    24. Targeting GIPC could be a promising new treatment option for pancreatic cancer. PMID: 18314626
    25. GIPC1 protein is overexpressed in ovarian and breast cancer PMID: 18721484
    26. GIPC1 is a novel breast cancer-associated immunogenic antigen that is overexpressed in breast cancer PMID: 18721486
    27. Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC PMID: 18775991
    28. the C-terminal PDZ-binding motif of Glut1 plays a key role in growth factor regulation of glucose uptake by both allowing GIPC to promote Glut1 trafficking to the cell surface and protecting intracellular Glut1 from lysosomal degradation. PMID: 19016655

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Membrane; Peripheral membrane protein.
  • 蛋白家族:
    GIPC family
  • 組織特異性:
    Widely expressed. Expressed in skeletal muscle (at protein level).
  • 數據庫鏈接:

    HGNC: 1226

    OMIM: 605072

    KEGG: hsa:10755

    STRING: 9606.ENSP00000340698

    UniGene: Hs.655012



主站蜘蛛池模板: 久久久国产精品va麻豆| 国产精品1区2区3区在线观看| 色哟哟在线视频精品一区| 成人亚洲一区无码久久| 色婷婷av一区二区三区浪潮| 隔壁人妻偷人bd中字| 337人体做爰大胆视频| 免费国产成人高清在线视频| 老子影院午夜伦手机不四虎卡| 国产国产乱老熟女视频网站97| 国产精品成人无码久久久| 欧美亚洲国产手机在线有码| 日韩精品 中文字幕 视频在线| 精品国产一区二区三区av性色| 亚洲国产精品一区二区久久| 国产超碰女人任你爽| 日本黄网站免费| 成人免费xxxxx在线观看| 午夜影视啪啪免费体验区入口| 亚洲一卡2卡三卡4卡无卡下载| 国产成人av一区二区在线观看| 综合色区亚洲熟妇另类| 伦理片午夜视频在线观看| 国产69精品久久久久乱码韩国| 午夜精品久久久久久毛片| 人妻洗澡被强公日日澡电影| 久久久99无码一区| 国产日韩欧美一区二区东京热| 成人欧美日韩一区二区三区 | 国产丝袜肉丝视频在线| 在线日韩av免费永久观看| 国产色视频一区二区三区| a∨变态另类天堂无码专区| 日韩人妻少妇一区二区三区| 久久人人玩人妻潮喷内射人人| 国产xxxxx在线观看| 婷婷五月综合国产激情| 国产女人18毛片水真多| 亚洲欧美一区二区三区| 国产成人年无码av片在线观看| 欧美精品黑人粗大视频|