在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Orexin receptor type 2 (HCRTR2), partial

Recombinant Human Orexin receptor type 2 (HCRTR2), partial

  • 中文名稱：
    人HCRTR2重組蛋白
  • 貨號：
    CSB-YP010232HU
  • 規(guī)格：
    ￥2208
  • 圖片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

產(chǎn)品詳情

  • 純度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Hcr tr2; Hcrt receptor 2; Hcrtr2; Hypocretin (orexin) receptor 2; Hypocretin receptor 2; Hypocretin receptor type 2; Orexin 2 receptor; Orexin A/Orexin B receptor; Orexin receptor 2; Orexin receptor type 2; Orexin type 2 receptor; Ox-2-R; Ox2-R; Ox2r; OX2R_HUMAN; Type 2 hypocretin receptor; Type 2 orexin receptor
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 來源：
    Yeast
  • 分子量：
    10.8kDa
  • 蛋白標(biāo)簽：
    N-terminal His-tagged/Tag-Free
  • 產(chǎn)品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Nonselective, high-affinity receptor for both orexin-A and orexin-B neuropeptides. Triggers an increase in cytoplasmic Ca(2+) levels in response to orexin-A binding.
  • 基因功能參考文獻(xiàn)：
    1. The rs2653349 (G1246A) polymorphism of the HCRTR2 gene reduces the chance of developing cluster headache. PMID: 29959630
    2. Association between HCRTR2, ADH4,CLOCK gene polymorphisms and cluster headache was not significant in the present study. PMID: 29318394
    3. The present study demonstrated that aa residues in the C-terminus serve an important role in the expression and signal transduction of OX2R. In addition, the aa residues in different locations possess evidentially different roles. PMID: 28487995
    4. This study showed that Lack of Association between Genetic Polymorphism of ox2r gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population PMID: 27335043
    5. G-protein-dependency of OX2 receptor signalling PMID: 27237973
    6. Rapid-onset obesity with hypothalamic dysfunction, hypoventilation, and autonomic dysregulation is highly unlikely to be caused by mutations in the exons of the HCRTR2 gene. PMID: 26555080
    7. The study determined structures of OX1R bound to the OX1R-selective antagonist SB-674042 and the dual antagonist suvorexant at 2.8-A and 2.75-A resolution and explored mechanisms of antagonist the subtype selectivity between OX1R and OX2R. PMID: 26950369
    8. our meta-analysis provides genetic evidence for a role of HCRTR2 in cluster headache PMID: 25398231
    9. Heart failure patients with minor allele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have improved left ventricular function and a lower prevalence of ejection fraction >35% PMID: 26653627
    10. the nonsynonymous rs2653349 single nucleotide polymorphism (SNP) (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with Fagerstrom Test for Nicotine Dependence. PMID: 26289589
    11. Antibodies from vaccine-associated narcolepsy sera cross-reacted with both influenza nucleoprotein and hypocretin receptor 2. PMID: 26136476
    12. The genotypic and allelic frequencies of the rs2653349 polymorphism were different between Alzheimer's disease patients and controls. The carriage of the G allele was associated with an increased AD risk. PMID: 24969517
    13. using lipid-mediated crystallization and protein engineering with a novel fusion chimaera, the structure of the human OX2R bound to suvorexant at 2.5 A resolution is solved PMID: 25533960
    14. DQ B1 but not HLA-DR typing, TNF-alpha levers, HCRTR1 and HCRTR2 were higher in narcolepsy-cataplexy/schizophrenia patients. PMID: 24268496
    15. Orexinergic innervation and expression of genes encoding OX2R receptor are upregulated in transgenic mice at dusk. PMID: 24599460
    16. Expression of the OX2R protein was detected in normal endometrial epithelia, whereas it was frequently lacking in endometrial endometrioid carcinoma. PMID: 23482607
    17. Data demonstrated that hOX2R expression is regulated by a complex involving a proximal PKA/PKC-regulated promoter and a distal promoter regulating tissue-specific expression of alternative transcripts which in turn regulate receptor levels. PMID: 20156195
    18. The data suggest that the HCRTR2 gene or a linked locus significantly modulates the risk for cluster headache. PMID: 15477554
    19. All adrenal cortex adenomas expressed OX1-R and OX2-R mRNAs, and real-time PCR showed that the expression of both receptors was up-regulated in adenomas PMID: 15797953
    20. Our results do not support a role of the HCRTR2 G1246A polymorphism in drug responses in CH. PMID: 17376114
    21. polymorphism of the HCRTR2 gene may modulate the genetic risk for cluster headache PMID: 17563843
    22. the HCRTR2 gene is not a genetic risk factor in migraine. PMID: 17645762
    23. This study does not support a major contribution of the HCRTR2 G1246A polymorphism to the pathogenesis of migraine in contrast to its effects in cluster headache. PMID: 17883525
    24. Three new polymorphisms of the HCRTR2 gene are significantly associated with cluster headache. PMID: 18399985
    25. This study describes the intracellular signalling pathways involved in OX2R-mediated ERK(1/2) and p38 MAPK activation. PMID: 18599270
    26. Biochemical and behavioural characterization of EMPA, a novel high-affinity, selective antagonist for the OX(2) receptor. PMID: 19751316

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 4849

    OMIM: 602393

    KEGG: hsa:3062

    STRING: 9606.ENSP00000359899

    UniGene: Hs.151624



主站蜘蛛池模板： 最近更新中文字幕| 久久精品九九亚洲精品天堂 | 亚洲乱码中文字幕小综合| 欧美成人一区二区三区在线观看| 国产免费又爽又色又粗视频| 噜噜色综合噜噜色噜噜色| 色v99在线影院| 中文字幕亚洲综合久久综合| 毛片大全真人在线| 国产又黄又爽胸又大免费视频| 国产成人精品一区二区三区免费| 69精品人人人人| 亚洲精品国产熟女久久久| 亚洲va在线va天堂xx xx| 成 人 社区在线视频| 2022一本久道久久综合狂躁| yy111111少妇无码影院| 欧美老熟妇喷水| 18禁真人抽搐一进一出在线| 精产国品一二三产品麻豆| 毛片内射久久久一区| 亚洲第一av网站| 国产精品久久久久秋霞鲁丝| 欧美日韩人妻精品一区二区在线| 久久综合给合久久97色| 久久丫精品久久丫| 首页 综合国产 亚洲 丝袜 | 韩国三级丰满少妇高潮| 精国产品一区二区三区a片| 亚洲 欧美 另类图片| 亚洲欧洲日产无码中文字幕| 亚洲欧美乱综合图片区小说区| 亚洲成av人片久久| 国产精品亚洲а∨天堂免下载| 狠狠综合久久久久尤物| 国产一区日韩二区欧美三区| 亚洲大尺度无码无码专线一区| 1000部又爽又黄无遮挡的视频 | 午夜爱爱爱爱爽爽爽网站 | 麻豆国产成人av在线播放| 爽到高潮无码视频在线观看|