在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Numb-like protein (NUMBL)

  • 中文名稱:
    人NUMBL重組蛋白
  • 貨號:
    CSB-YP897595HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NUMBL重組蛋白
  • 貨號:
    CSB-EP897595HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NUMBL重組蛋白
  • 貨號:
    CSB-EP897595HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NUMBL重組蛋白
  • 貨號:
    CSB-BP897595HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NUMBL重組蛋白
  • 貨號:
    CSB-MP897595HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CAG 3A; CAG3A; CTG 3a; CTG3a; NBL; NUMB Drosophilia Homolog Like; Numb homolog (Drosophila) like; Numb homolog like; Numb like protein; NUMB R; Numb-like protein; Numb-R; Numb-related gene; Numb-related protein; NUMBL; NUMBL_HUMAN; NUMBLIKE; NUMBR; TNRC 23; TNRC23; Trinucleotide repeat-containing gene 23
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-609
  • 氨基酸序列
    MSRSAAASGG PRRPERHLPP APCGAPGPPE TCRTEPDGAG TMNKLRQSLR RRKPAYVPEA SRPHQWQADE DAVRKGTCSF PVRYLGHVEV EESRGMHVCE DAVKKLKAMG RKSVKSVLWV SADGLRVVDD KTKDLLVDQT IEKVSFCAPD RNLDKAFSYI CRDGTTRRWI CHCFLALKDS GERLSHAVGC AFAACLERKQ RREKECGVTA AFDASRTSFA REGSFRLSGG GRPAEREAPD KKKAEAAAAP TVAPGPAQPG HVSPTPATTS PGEKGEAGTP VAAGTTAAAI PRRHAPLEQL VRQGSFRGFP ALSQKNSPFK RQLSLRLNEL PSTLQRRTDF QVKGTVPEME PPGAGDSDSI NALCTQISSS FASAGAPAPG PPPATTGTSA WGEPSVPPAA AFQPGHKRTP SEAERWLEEV SQVAKAQQQQ QQQQQQQQQQ QQQQQQAASV APVPTMPPAL QPFPAPVGPF DAAPAQVAVF LPPPHMQPPF VPAYPGLGYP PMPRVPVVGI TPSQMVANAF CSAAQLQPQP ATLLGKAGAF PPPAIPSAPG SQARPRPNGA PWPPEPAPAP APELDPFEAQ WAALEGKATV EKPSNPFSGD LQKTFEIEL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons.
  • 基因功能參考文獻:
    1. NumbL can act as an independent tumor suppressor inhibiting the Notch pathway and regulating the cancer stem cell pool PMID: 27613838
    2. let-7c inhibits Notch and progression markers but up-regulates Numbl in pancreatic cancer treated with quercetin PMID: 27521217
    3. Numbl might be involved in the inhibition of growth, proliferation, and invasion of 95-D lung cancer cells. PMID: 23681800
    4. Numbl-Klf4 signaling is critical to maintain multiple nodes of metastatic progression, including persistence of cancer-initiating cells. PMID: 23440423
    5. data suggest that Numbl regulates glioma cell migration and invasion by abrogating TRAF5-induced activation of NF-KappaB PMID: 22593207
    6. NUMBL interacts with TRAF6 and promotes the degradation of TRAF6 in vivo, leading to the inhibition of NF-kappaB signaling pathway. PMID: 20079715
    7. Both gene sequence alterations and amplifications of LNX1 and Numbl are present in a subset of human gliomas. PMID: 18940473

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 數據庫鏈接:

    HGNC: 8061

    OMIM: 604018

    KEGG: hsa:9253

    STRING: 9606.ENSP00000252891

    UniGene: Hs.326953



主站蜘蛛池模板: 国产欧美在线观看不卡| 久久天天躁狠狠躁夜夜2o2o| 无码综合天天久久综合网色吧影院 | 精品国产欧美一区二区| 西西人体大胆午夜啪啪| 在线观看免费人成视频网| 国产精品美女乱子伦高潮| 午夜福利理论片高清在线观看| 亚洲熟妇国产熟妇肥婆| 国产玉足脚交极品在线播放| 狠狠噜天天噜日日噜色综合| 亚洲欧美日韩中文在线制服| 久久久精品午夜免费不卡| 朝鲜女人大白屁股ass| 国产精品久久国产精品99盘| 国产+成+人+亚洲欧洲自线| 色综合久久久无码中文字幕波多| 精品久久久久久无码人妻热| 国产区精品系列在线观看| 丰满人妻熟妇乱又伦精品app| 久久97超碰色中文字幕总站| 国产露脸150部国语对白| 中文字幕无码一区二区免费| 国产亚洲中文日韩欧美综合网| 久久精品中文字幕第一页| 国产网红无码精品视频| 国产乱视频在线观看| 国产在线精品视频二区| 人妻三级日本香港三级极97| 欧美牲交a欧美牲交aⅴ一| 久久精品国产精品青草| 亚洲精品综合一区二区三| 精品一卡2卡三卡4卡免费网站| 欧美激情性做爰免费视频| 寂寞骚妇被后入式爆草抓爆 | 毛片免费视频观看| 国产又爽又黄无码无遮挡在线观看| 日本成本人三级在线观看| 精品少妇人妻av免费久久洗澡| 国产无遮挡a片又黄又爽| 人妻无码久久中文字幕专区|