在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Nuclear valosin-containing protein-like (NVL), partial

  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-YP016216HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-EP016216HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-EP016216HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-BP016216HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-MP016216HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    NVL
  • Uniprot No.:
  • 別名:
    Nuclear valosin containing protein like; Nuclear valosin-containing protein-like; Nuclear VCP like; Nuclear VCP-like protein; Nvl; NVL_HUMAN; NVLp; OTTHUMP00000035641; OTTHUMP00000216593; OTTHUMP00000216594; OTTHUMP00000216599; OTTHUMP00000216600
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.
  • 基因功能參考文獻:
    1. knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed. PMID: 29107693
    2. Results indicated that the NVL gene may contain overlapping common genetic risk factors for major depressive disorder and schizophrenia in the Han Chinese population PMID: 25891250
    3. results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis PMID: 26456651
    4. suggest that NVL2 is involved in pre-rRNA processing by associating with the nuclear exosome complex and that MPP6 is required for maintaining the integrity of this rRNA processing complex PMID: 26166824
    5. these findings suggest that NVL2 is essential for telomerase biogenesis and provides an alternative approach for inhibiting telomerase activity in cancer. PMID: 22226966
    6. interaction of NVL2 with ribosomal protein L5 is ATP-dependent and likely contributes to the nucleolar translocation of NVL2 PMID: 15469983
    7. Nuclear VCP/p97-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone. PMID: 16782053

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm.
  • 蛋白家族:
    AAA ATPase family
  • 組織特異性:
    Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
  • 數據庫鏈接:

    HGNC: 8070

    OMIM: 602426

    KEGG: hsa:4931

    STRING: 9606.ENSP00000281701

    UniGene: Hs.497867



主站蜘蛛池模板: yyyy11111少妇影院| 久久亚洲国产精品成人av秋霞| 国产精品一区二区av麻豆| 久久精品国产999久久久| 色老99久久精品偷偷鲁| 欧洲熟妇色xxxx欧美老妇多毛| 韩国精品福利一区二区三区 | 亚洲成av人片在线观看天堂无| 亚洲1卡二卡三新区2022| 又色又爽又黄的视频网站| 中文无码成人免费视频在线观看| 黑人尾随强伦姧人妻爽翻天| 国产成人av大片在线播放| 色偷偷亚洲男人本色| 亚洲国产成人综合一区二区三区| 成人精品一区二区三区电影免费| 丰满人妻无奈张开双腿av| 亚洲国产欧美在线人成| 狠狠色狠狠色综合日日不卡| 特黄做受又硬又粗又大视频小说| awww在线天堂bd资源在线| 国产精品成人无码免费| 亚欧成a人无码精品va片| 国产精品_九九99久久精品| 色哟哟精品视频在线观看 | 亚洲2022国产成人精品无码区| 新区乱码无人区二精东| 十八禁无码免费网站| 国模无码视频一区二区三区| 69久久国产露脸精品国产 | 无码国产成人久久| 人妻无码视频一区二区三区| 一本一道vs无码中文字幕| 精品一卡2卡3卡4卡新区在线| 成人欧美一区二区三区| 日韩精品无码一区二区中文字幕 | 精品无码专区毛片| www国产精品内射| 亚洲熟妇av一区二区三区宅男| 夜夜躁天天躁很很躁| 小雪尝禁果又粗又大的视频|