在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Nuclear valosin-containing protein-like (NVL), partial

  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-YP016216HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-EP016216HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-EP016216HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-BP016216HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NVL重組蛋白
  • 貨號:
    CSB-MP016216HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    NVL
  • Uniprot No.:
  • 別名:
    Nuclear valosin containing protein like; Nuclear valosin-containing protein-like; Nuclear VCP like; Nuclear VCP-like protein; Nvl; NVL_HUMAN; NVLp; OTTHUMP00000035641; OTTHUMP00000216593; OTTHUMP00000216594; OTTHUMP00000216599; OTTHUMP00000216600
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.
  • 基因功能參考文獻:
    1. knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed. PMID: 29107693
    2. Results indicated that the NVL gene may contain overlapping common genetic risk factors for major depressive disorder and schizophrenia in the Han Chinese population PMID: 25891250
    3. results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis PMID: 26456651
    4. suggest that NVL2 is involved in pre-rRNA processing by associating with the nuclear exosome complex and that MPP6 is required for maintaining the integrity of this rRNA processing complex PMID: 26166824
    5. these findings suggest that NVL2 is essential for telomerase biogenesis and provides an alternative approach for inhibiting telomerase activity in cancer. PMID: 22226966
    6. interaction of NVL2 with ribosomal protein L5 is ATP-dependent and likely contributes to the nucleolar translocation of NVL2 PMID: 15469983
    7. Nuclear VCP/p97-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone. PMID: 16782053

    顯示更多

    收起更多

  • 亞細胞定位:
    [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm.
  • 蛋白家族:
    AAA ATPase family
  • 組織特異性:
    Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
  • 數據庫鏈接:

    HGNC: 8070

    OMIM: 602426

    KEGG: hsa:4931

    STRING: 9606.ENSP00000281701

    UniGene: Hs.497867



主站蜘蛛池模板: 国产高清在线a视频大全| 亚洲精品无码aⅴ中文字幕蜜桃| 亚洲 欧美 日韩 综合aⅴ视频| 亚洲中文字幕无码中文字在线| 男人女人午夜视频免费| 最新国产久免费视频在线观看| 久久天天躁狠狠躁夜夜爽| 亚洲国产av美女网站| аⅴ天堂中文在线网官网| 国产成人午夜福利在线小电影| 免费无码久久成人网站入口| 久久婷婷五月综合色国产| 性夜夜春夜夜爽aa片a| 日本道免费精品一区二区| 亚洲综合久久成人a片| 国产成人久久婷婷精品流白浆| 国产精品丝袜久久久久久不卡| 亚洲色成人四虎在线观看| av制服丝袜白丝国产网站| 狠狠综合久久av一区二区| 大香伊蕉在人线国产网站首页 | 人妻被按摩师玩弄到潮喷| 人人做人人爽久久久精品| 2021久久国自产拍精品| 国产精品白丝喷水在线观看| 精品国产乱码久久久久app下载| 在线看片免费人成视频国产片| 亚洲精品久久久久中文字幕| 真人做人试看60分钟免费| 亚洲国产精品一区二区手机| 农村乱人伦一区二区| 狠狠色综合7777久夜色撩人ⅰ| 中文字幕乱码人在线视频1区 | 天天躁夜夜躁狠狠躁2020| 亚州久久久久区1区2少妇| 女人下边被添全过视频的网址| 亚洲女人自熨在线视频| 少妇人妻久久无码专区| 亚洲国产av美女网站| 蜜臀亚洲精品国产aⅴ综合第一| 天天av天天av天天透|