在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NVL Antibody

  • 中文名稱(chēng):
    NVL兔多克隆抗體
  • 貨號(hào):
    CSB-PA016216GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    NVL
  • 別名:
    Nuclear valosin containing protein like antibody; Nuclear valosin-containing protein-like antibody; Nuclear VCP like antibody; Nuclear VCP-like protein antibody; Nvl antibody; NVL_HUMAN antibody; NVLp antibody; OTTHUMP00000035641 antibody; OTTHUMP00000216593 antibody; OTTHUMP00000216594 antibody; OTTHUMP00000216599 antibody; OTTHUMP00000216600 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human NVL
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Participates in the assembly of the telomerase holoenzyme and effecting of telomerase activity via its interaction with TERT. Involved in both early and late stages of the pre-rRNA processing pathways. Spatiotemporally regulates 60S ribosomal subunit biogenesis in the nucleolus. Catalyzes the release of specific assembly factors, such as WDR74, from pre-60S ribosomal particles through the ATPase activity.
  • 基因功能參考文獻(xiàn):
    1. knockdown of WDR74 leads to significant defects in the pre-rRNA cleavage within the internal transcribed spacer 1, occurring in an early stage of the processing pathway. When the dissociation of WDR74 from the MTR4-containing exonuclease complex was impaired upon expression of mutant NVL2, the same processing defect, with partial migration of WDR74 from the nucleolus towards the nucleoplasm, was observed. PMID: 29107693
    2. Results indicated that the NVL gene may contain overlapping common genetic risk factors for major depressive disorder and schizophrenia in the Han Chinese population PMID: 25891250
    3. results suggest that WDR74 is a novel regulatory protein of the MTR4-exsosome complex whose interaction is regulated by NVL2 and is involved in ribosome biogenesis PMID: 26456651
    4. suggest that NVL2 is involved in pre-rRNA processing by associating with the nuclear exosome complex and that MPP6 is required for maintaining the integrity of this rRNA processing complex PMID: 26166824
    5. these findings suggest that NVL2 is essential for telomerase biogenesis and provides an alternative approach for inhibiting telomerase activity in cancer. PMID: 22226966
    6. interaction of NVL2 with ribosomal protein L5 is ATP-dependent and likely contributes to the nucleolar translocation of NVL2 PMID: 15469983
    7. Nuclear VCP/p97-like protein 2 might regulate the association/dissociation reaction of DOB1 with pre-ribosomal particles by acting as a molecular chaperone. PMID: 16782053

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    [Isoform 2]: Nucleus, nucleoplasm.; [Isoform 1]: Nucleus, nucleolus. Nucleus, nucleoplasm.
  • 蛋白家族:
    AAA ATPase family
  • 組織特異性:
    Widely expressed. Highest level of expression in heart, placenta, skeletal muscle, pancreas and retina.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 8070

    OMIM: 602426

    KEGG: hsa:4931

    STRING: 9606.ENSP00000281701

    UniGene: Hs.497867



主站蜘蛛池模板: 一本一道av中文字幕无码| 97久久超碰亚洲视觉盛宴| 大肉大捧一进一出视频 | 黑人上司粗大拔不出来电影| 97国产超碰一区二区三区| 男人边吃奶边揉好爽免费视频| 国产a在亚洲线播放| 久久99精品国产麻豆蜜芽| 一个人看免费视频www| 中文字幕无线观看中文字幕| 免费的黄网站在线观看| 国产一区二区三区 韩国女主播 | 人与性动交aaaabbbb| 无码欧精品亚洲日韩一区| 亚洲欧洲日产国码中文字幕| 99精品全国免费观看视频| 6699嫩草久久久精品影院| 欧美牲交a欧美在线| 精品国内综合一区二区| 亚洲精品国产一区二区的区别| 亚洲日韩国产成网在线观看| 国产做爰xxxⅹ高潮视频12p| 国产精华av午夜在线观看| 免费人成视频在线播放| 精品人妻系列无码人妻不卡| 国产丰满乱子伦无码专区| 国模雨珍浓密毛大尺度150p| 色综合中文综合网| 亚洲综合色婷婷七月丁香| 久久精品av一区二区免费| 狠狠躁天天躁夜夜躁婷婷| 少妇无套内谢久久久久| 天天躁日日躁狠狠躁性色av| 一本色综合亚洲精品蜜桃冫| 日本熟妇人妻xxxxx| 亚洲国产成av人天堂无码| 精品免费国产一区二区三区四区介绍 | 中文 在线 日韩 亚洲 欧美| 亚洲aⅴ天堂av天堂无码| 西西人体www大胆高清视频| 在线成人a毛片免费播放|