在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Nuclear factor of activated T-cells 5 (NFAT5), partial

  • 中文名稱:
    人NFAT5重組蛋白
  • 貨號:
    CSB-YP015744HU
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NFAT5重組蛋白
  • 貨號:
    CSB-EP015744HU
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NFAT5重組蛋白
  • 貨號:
    CSB-EP015744HU-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NFAT5重組蛋白
  • 貨號:
    CSB-BP015744HU
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NFAT5重組蛋白
  • 貨號:
    CSB-MP015744HU
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Glutamine rich protein H65; KIAA0827; NF AT5; NF-AT5; NFAT 5; NFAT L1; NFAT like protein 1; NFAT5; NFAT5_HUMAN; NFATL 1; NFATL1; NFATZ; Nuclear factor of activated T cells 5; Nuclear factor of activated T cells 5 tonicity responsive; Nuclear factor of activated T cells; Nuclear factor of activated T-cells 5; OREBP; Osmotic response element binding protein; T cell transcription factor NFAT 5; T cell transcription factor NFAT5; T-cell transcription factor NFAT5; TonE binding protein; TonE-binding protein; TonEBP; Tonicity responsive enhancer binding protein; Tonicity-responsive enhancer-binding protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Transcription factor involved, among others, in the transcriptional regulation of osmoprotective and inflammatory genes. Mediates the transcriptional response to hypertonicity. Positively regulates the transcription of LCN2 and S100A4 genes; optimal transactivation of these genes requires the presence of DDX5/DDX17. Binds the DNA consensus sequence 5'-[ACT][AG]TGGAAA[CAT]A[TA][ATC][CA][ATG][GT][GAC][CG][CT]-3'.
  • 基因功能參考文獻:
    1. Results show that higher levels of NFAT5 expression predict a good prognosis in patients with hepatocellular carcinoma (HCC), suggesting that NFAT5 is a potential tumor-suppressing gene, and verify that NFAT5 promotes hepatoma cell apoptosis and inhibits cell growth in vitro. Also, HBV inhibits NFAT5 expression by inducing hypermethylation of the AP1-binding site in the NFAT5 promoter. PMID: 29052520
    2. the NFAT5 pathway was involved in the regulation of biomechanical stretch-induced human arterial smooth muscle cell (HUASMC) proliferation, inflammation, and migration. Stretch promoted the expression of NFAT5 in human arterial smooth muscle cells and regulated through activation of c-Jun N-terminal kinase under these conditions PMID: 28840417
    3. TonEBP suppresses M2 phenotype via downregulation of the IL-10 in M1 macrophages. PMID: 27160066
    4. In addition to finding many proteins already known to associate with NFAT5, many new ones whose function suggest novel aspects of NFAT5 regulation, interaction, and function, were also found. PMID: 27764768
    5. The data suggest that in addition to calcium signaling and activation of inflammatory enzymes, autocrine/paracrine purinergic signaling contributes to the stimulatory effect of hyperosmotic stress on the expression of the NFAT5 gene in retinal pigment epithelial cells. PMID: 28356704
    6. NFAT5-mediated expression of CACNA1C is evolutionarily conserved. NFAT5-mediated CACNA1C expression is critical for cardiac electrophysiological development and maturation. PMID: 27368804
    7. Data suggest that protease 2A of CVB3 exhibits substrate specificity that includes human/mouse NFAT5 in cardiomyocytes; NFAT5 inhibits CVB3 replication via mechanism that involves iNOS; anti-CVB3 activity of NFAT5 is impaired during CVB3 infection due to protease 2A-mediated cleavage of NFAT5. (CVB3 = Coxsackievirus 3; NFAT5 = tonicity-responsive nuclear factor of activated T-cells 5; iNOS = nitric oxide synthase type II) PMID: 29220410
    8. TonEBP expression correlated with canonical osmoregulatory targets TauT/SLC6A6, SMIT/SLC5A3, and AR/AKR1B1, supporting in vitro findings that the inflammatory milieu during IDD does not interfere with TonEBP osmoregulation. In summary, whereas TonEBP participates in the proinflammatory response to TNF-alpha PMID: 28842479
    9. results provide evidence that NFAT5 expression in macrophages enhances chronic arthritis by conferring apoptotic resistance to activated macrophages. PMID: 28192374
    10. genetic variation in NFAT5 expression and function in the central nervous system may affect the regulation of systemic water balance PMID: 28360221
    11. The hyperosmotic AR gene expression was dependent on activation of metalloproteinases, autocrine/paracrine TGF-beta signaling, activation of p38 MAPK, ERK1/2, and PI3K signal transduction pathways, and the transcriptional activity of NFAT5. PMID: 27628063
    12. Conclusion. miR-20b acts as a tumor suppressor in the development of thymoma and thymoma-associated myasthenia gravis. The tumor suppressive function of miR-20b in thymoma could be due to its inhibition of NFAT signaling by repression of NFAT5 and CAMTA1 expression. PMID: 27833920
    13. The hyperosmotic, but not the hypoxic, PlGF gene expression was in part mediated by NFAT5. PMID: 27230578
    14. Proteins associated with and binding NH2-terminal region of NFAT5.NUP160 and NUP205 contribute to regulation of NFAT5 transcriptional activity PMID: 26757802
    15. Our data demonstrates the involvement of TonEBP in the mechanisms responsible for osmoadaptation to hyperosmolar stress in retinal pigment epithelium cells. PMID: 26912969
    16. Additionally, in peritoneal dialysis the cells of the peritoneal cavity are repeatedly exposed to a rise and fall in osmotic concentrations. Here we review the current information about NFAT5 in uremic patients and patients on peritoneal dialysis. PMID: 26495302
    17. Results suggest that the NFAT5 gene, which is upregulated a few hours after cocaine exposure, may be involved in the genetic predisposition to cocaine dependence. PMID: 26506053
    18. NFAT5 pathway activation might have a relevant role in inflammatory breast cancer pathogenesis PMID: 25928084
    19. Real-time PCR and Western blot analysis confirmed up-regulation of NFAT5 mRNA and NFAT5 nuclear content in human preeclamptic placentas PMID: 25995271
    20. These results indicate that NFAT5 plays important roles in proliferation and migration of human lung adenocarcinoma cells through regulating AQP5 expression, providing a new therapeutic option for lung adenocarcinoma therapy. PMID: 26299924
    21. The hyperosmotic induction of AQP5 and VEGF in retinal pigment epithelial cells was in part dependent on activation of NFAT5. PMID: 25878490
    22. Upregulation of NFAT5 in peritoneal dialysis patients is associated with NFkappaB induction, potentially resulting in the recruitment of macrophages PMID: 25834072
    23. NFAT5 participates in the regulation of intestinal homeostasis via the suppression of mTORC1/Notch signaling pathway. PMID: 25057011
    24. PKC-alpha contributes to high NaCl-dependent activation of NFAT5 through ERK1/2. PMID: 25391900
    25. Data indicate that nuclear factor of activated T cells 5 (NFAT5) is a direct target of miR-568. PMID: 24355664
    26. these data support a novel function of the XO-NFAT5 axis in macrophage activation and TLR-induced arthritis PMID: 25044064
    27. Suggest that biomechanical stretch is sufficient to activate NFAT5 both in native and cultured VSMCs where it regulates the expression of tenascin-C. PMID: 24614757
    28. NFAT5 regulation of intestinal cell differentiation may be through inhibition of Wnt/beta-catenin signaling. PMID: 23764852
    29. Nfat5 may be involved in regulating chondrogenic differentiation of these cells under both normal and increased osmolarities and might regulate chondrogenic differentiation through influencing early Sox9 expression PMID: 23219947
    30. It was concluded that specific DNA binding of NFAT5 contributes to its nuclear localization, by mechanisms as yet undetermined, but independent of ones previously described. PMID: 22992674
    31. Non-invasive imaging of nuclear factor of activated T-cell 5 (NFAT5) activation follows middle cerebral artery occlusion (MCAO) in NFAT5-luciferase-expressing mice. PMID: 21749466
    32. NFAT5 is induced by hypoxia and could be a protective factor against ischemic damage. PMID: 22768306
    33. NFAT5 contributes to osmolality-induced MCP-1 expression in mesothelial cells PMID: 22619484
    34. The nuclear transport of NFAT5a involves reversible palmitoylation. PMID: 22071693
    35. the innate immune response to MTb infection induces NFAT5 gene and protein expression, and NFAT5 plays a crucial role in MTb regulation of HIV-1 replication via a direct interaction with the viral promoter. PMID: 22496647
    36. These data indicate that NS5A modulates Hsp72 via NFAT5 and reactive oxygen species activation for hepatitis C virus propagation. PMID: 22497815
    37. These results suggested that TonEBP played an important role in the epithelial cells of renal proximal tubule upon hypertonic stress by enhancing AAD expression, which could promote dopamine secretion to negative regulate Na+/K+-ATPase activity. PMID: 21982764
    38. Compared with control group, the levels of OREBP, HSP70-2 and MUC5AC in supernatant significantly increased after HBE16 cells were exposed to hypertonic media. PMID: 21418859
    39. Identify NFAT5 as a novel regulator of vascular smooth muscle cell phenotypic modulation. PMID: 21757659
    40. NF-AT5 regulates synovial proliferation and angiogenesis in chronic arthritis. PMID: 21717420
    41. this study demonstrates that hyperosmotic stress induces S100A4 through NFAT5, and Src and chromatin remodeling are involved. PMID: 21289293
    42. High NaCl-induced increase of the overall abundance of TonEBP/OREBP, by itself, eventually raises its effective level in the nucleus, but its rapid CDK5-dependent nuclear localization accelerates the process. PMID: 21209322
    43. These findings reveal a novel role for TonEBP and Akt in NF-kappaB activation on the onset of hypertonic challenge. PMID: 20685965
    44. NFAT5-null mice have constitutive, pronounced hypernatremia and suffer severe immunodeficiency with T cell lymphopenia, altered CD8 naive/memory homeostasis, and inability to reject allogeneic tumors. PMID: 21037089
    45. c-Abl is the kinase responsible for high NaCl-induced phosphorylation of TonEBP/OREBP-Y143 PMID: 20585028
    46. TonEBP/OREBP is extensively regulated by phosphatases, including SHP-1, whose inhibition by high NaCl increases phosphorylation of TonEBP/OREBP at Y143, contributing to the nuclear localization and activation of TonEBP/OREBP PMID: 20351292
    47. The loss of nucleosome(s) was found to be initiated by an OREBP-independent mechanism, but was significantly potentiated in the presence of OREBP. PMID: 20041176
    48. TonEBP/OREBP becomes phosphorylated at Y143, resulting in binding of PLC-gamma1 to that site, which contributes to TonEBP/OREBP transcriptional activity. PMID: 20080774
    49. NFAT5 exclusion from mitotic chromatin resets its nucleo-cytoplasmic distribution in interphase PMID: 19750013
    50. present in placenta at RNA and protein levels PMID: 19886771

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 組織特異性:
    Widely expressed, with highest levels in skeletal muscle, brain, heart and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 7774

    OMIM: 604708

    KEGG: hsa:10725

    STRING: 9606.ENSP00000396538

    UniGene: Hs.371987



主站蜘蛛池模板: 亚洲人成伊人成综合网中文| 一本大道无码日韩精品影视丶 | 国产午夜视频在线观看| 精品爆乳一区二区三区无码av| 伊人久久丁香色婷婷啪啪 | 亚洲色偷偷色噜噜狠狠99网| 亚洲国产一卡2卡3卡4卡5公司| 性欧美丰满熟妇xxxx性5| 欧美日韩国产专区一区二区| 青青草原亚洲| 亚洲国产aⅴ成人精品无吗| 久久视频这里有精品33| 午夜人成免费视频| 热99re久久精品这里都是精品免费 | 少妇激情一区二区三区视频小说| 久久精品久久电影免费理论片| 日本道精品一区二区三区| 制服丝袜亚洲欧美中文字幕| 丰满的少妇xxxxx青青青| 久久婷婷色综合一区二区| 久久综合伊人九色综合| 成人免费无码视频在线网站 | av无码一区二区三区| 国产亚洲成av片在线观看 | 24小时日本在线www免费的| 亚洲性色成人av| 日韩av无码精品一二三区| 亚洲一区二区三区高清av| 久久亚洲中文字幕精品一区| 午夜免费啪视频观看视频 | 亚洲精品色无码av试看| 国产无遮挡a片又黄又爽漫画| 亚洲熟妇无码一区二区三区| 久久精品国产亚洲一区二区| 一二三四观看视频社区在线| 四虎精品免费永久免费视频| 窝窝午夜理论片影院| 热久久美女精品天天吊色| 日日噜噜大屁股熟妇| 少妇又色又紧又爽又刺激视频| 美女国产毛片a区内射 |