在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Nitrogen permease regulator 2-like protein (NPRL2)

Recombinant Human Nitrogen permease regulator 2-like protein (NPRL2)

  • 中文名稱：
    人NPRL2重組蛋白
  • 貨號：
    CSB-YP840976HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NPRL2重組蛋白
  • 貨號：
    CSB-EP840976HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NPRL2重組蛋白
  • 貨號：
    CSB-EP840976HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NPRL2重組蛋白
  • 貨號：
    CSB-BP840976HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NPRL2重組蛋白
  • 貨號：
    CSB-MP840976HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    2810446G01Rik; G21 protein; Gene 21 protein; Homologous to yeast nitrogen permease (candidate tumor suppressor); Homologous to yeast nitrogen permease; Nitrogen permease regulator 2-like protein; Nitrogen permease regulator-like 2 (S. cerevisiae); NPR 2L; NPR L2; NPR like 2; NPR2; NPR2 like; NPR2-like protein; NPR2L; NPRL 2; NPRL2; NPRL2_HUMAN; Tumor suppressor candidate 4; TUSC 4; TUSC 4 protein; TUSC4; TUSC4 protein
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-380
  • 氨基酸序列
    MGSGCRIECI FFSEFHPTLG PKITYQVPED FISRELFDTV QVYIITKPEL QNKLITVTAM EKKLIGCPVC IEHKKYSRNA LLFNLGFVCD AQAKTCALEP IVKKLAGYLT TLELESSFVS MEESKQKLVP IMTILLEELN ASGRCTLPID ESNTIHLKVI EQRPDPPVAQ EYDVPVFTKD KEDFFNSQWD LTTQQILPYI DGFRHIQKIS AEADVELNLV RIAIQNLLYY GVVTLVSILQ YSNVYCPTPK VQDLVDDKSL QEACLSYVTK QGHKRASLRD VFQLYCSLSP GTTVRDLIGR HPQQLQHVDE RKLIQFGLMK NLIRRLQKYP VRVTREEQSH PARLYTGCHS YDEICCKTGM SYHELDERLE NDPNIIICWK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.; Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.
  • 基因功能參考文獻：
    1. NPRL2 overexpression enhances sensitivity to CPT-11 treatment in colon cancer cells. PMID: 29519997
    2. This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia. PMID: 27173016
    3. Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor. PMID: 26455908
    4. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. PMID: 26582740
    5. NPRL2 mutations are significant cause of focal epilepsy. PMID: 26505888
    6. NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines. PMID: 26044952
    7. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells. PMID: 25777765
    8. Decreased expression of NPRL2 is associated with renal cancer. PMID: 24789683
    9. NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers. PMID: 24521741
    10. Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer. PMID: 25480944
    11. NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma. PMID: 23321467
    12. Lower NPRL2 expression was observed significantly more frequently in poorly differentiated tumor samples than in highly or moderately differentiated colon tumors. PMID: 23079973
    13. Data indicate that Npr2, a homolog of human NPRL2, is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources. PMID: 20154027
    14. NPRL2 is a multiple tumor suppressor gene. PMID: 15374952
    15. Expression of NPRL2 was significantly and reciprocally correlated to cisplatin sensitivity. PMID: 17018626
    16. TUSC4/NPRL2, a novel PDK1-interacting protein, plays a role in regulating the Src/PDK1 signaling pathway and cell sensitivity to multiple cancer chemotherapeutic drugs. PMID: 18616680
    17. Our results suggest that NPRL2 mRNA expression has prognostic significance for the survival of patients with HCC. PMID: 19274676

    顯示更多

    收起更多

  • 相關疾病：
    Epilepsy, familial focal, with variable foci 2 (FFEVF2)
  • 亞細胞定位：
    Lysosome membrane.
  • 蛋白家族：
    NPR2 family
  • 組織特異性：
    Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes. Expressed in most lung cancer
  • 數據庫鏈接：

    HGNC: 24969

    OMIM: 607072

    KEGG: hsa:10641

    STRING: 9606.ENSP00000232501

    UniGene: Hs.437083



主站蜘蛛池模板： 97久章草在线视频播放| 国产精品激情av久久久青桔| 国产色视频一区二区三区| 久久久久人妻一区二区三区vr| 热久久99这里有精品综合久久| 久久人人97超碰caoporen| √天堂中文官网8在线| 天天做天天爱天天爽综合网| 99热成人精品热久久6网站| 国产欧美在线亚洲一区| 国产亚洲产品影市在线产品| 国产精品久免费的黄网站| 精品高朝久久久久9999| 少妇激情作爱视频| 伊人久久大香线蕉av色婷婷色 | 亚洲精品国产成人99久久6 | 99久久亚洲精品日本无码| 一本加勒比hezyo无码资源网| 成年午夜精品久久久精品| 免费视频好湿好紧好大好爽| 最新国产在线拍揄自揄视频| 2018av天堂在线视频精品观看| 亚洲精品国产精品国产自2022| 中文无码精品a∨在线| 日韩精品一区二区三区在线观看| www国产亚洲精品久久网站| 国产69精品久久久久乱码| 亚洲裸男自慰gv网站| 国产精品污www在线观看| 无翼乌工口全彩肉肉无遮挡18| 亚洲中文久久精品无码1| 久久综合九色综合欧美98| 黑人大战中国av女叫惨了| 亚洲国产精品成人影片久久| 中文字幕av无码一区二区三区电影| 亚洲男同志网站| 亚洲精品色播一区二区| 国产激情高中生呻吟视频| 午夜天堂精品久久久久| 男男女女爽爽爽免费视频| 天天综合色天天综合色hd|