在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. NPRL2 Antibody

NPRL2 Antibody

  • 中文名稱：
    NPRL2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA127552
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using CSB-PA127552(NPRL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA127552(NPRL2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • Gel: 10%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Human fetal muscle tissue, mouse skeletal muscle tissue, Primary antibody: CSB-PA127552(NPRL2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    2810446G01Rik antibody; G21 protein antibody; Gene 21 protein antibody; Homologous to yeast nitrogen permease (candidate tumor suppressor) antibody; Homologous to yeast nitrogen permease antibody; Nitrogen permease regulator 2-like protein antibody; Nitrogen permease regulator-like 2 (S. cerevisiae) antibody; NPR 2L antibody; NPR L2 antibody; NPR like 2 antibody; NPR2 antibody; NPR2 like antibody; NPR2-like protein antibody; NPR2L antibody; NPRL 2 antibody; NPRL2 antibody; NPRL2_HUMAN antibody; Tumor suppressor candidate 4 antibody; TUSC 4 antibody; TUSC 4 protein antibody; TUSC4 antibody; TUSC4 protein antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human NPRL2
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:200-1:1000
    IHC 1:50-1:200
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway.; Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs.
  • 基因功能參考文獻(xiàn)：
    1. NPRL2 overexpression enhances sensitivity to CPT-11 treatment in colon cancer cells. PMID: 29519997
    2. This study demonstrated that NPRL2 mutation in familial focal epilepsies and focal cortical dysplasia. PMID: 27173016
    3. Data confirmed NPRL2 was downregulated in gliomas. More importantly, NPRL2 was able to inhibit cell proliferation in vitro and repress tumorigenicity in vivo, suggesting its role as a tumor suppressor. PMID: 26455908
    4. The positive regulation of mTORC1 activity by NPRL2 is mediated through NPRL2 interaction with Raptor. PMID: 26582740
    5. NPRL2 mutations are significant cause of focal epilepsy. PMID: 26505888
    6. NPRL2 acts as a functional tumor suppressor in colorectal cancer cell lines. PMID: 26044952
    7. NPRL2 enhances sensitivity to oxaliplatin in colon cancer cells. PMID: 25777765
    8. Decreased expression of NPRL2 is associated with renal cancer. PMID: 24789683
    9. NPRL2 mRNA blood levels could be a potentially useful marker for the detection of early stage adenomas and colorectal cancers. PMID: 24521741
    10. Results provide a set of genetic and biologic proofs that TUSC4 functions as a bona fide tumor suppressor by regulating the protein stability and function of BRCA1 in breast cancer. PMID: 25480944
    11. NPRL2 expression is negatively related with the survival of osteosarcoma patients, indicating its value as a prognosis factor of osteosarcoma. PMID: 23321467
    12. Lower NPRL2 expression was observed significantly more frequently in poorly differentiated tumor samples than in highly or moderately differentiated colon tumors. PMID: 23079973
    13. Data indicate that Npr2, a homolog of human NPRL2, is a phosphorylation-dependent target of the SCF(Grr1) E3 ubiquitin ligase that plays a role in cell growth on some nitrogen sources. PMID: 20154027
    14. NPRL2 is a multiple tumor suppressor gene. PMID: 15374952
    15. Expression of NPRL2 was significantly and reciprocally correlated to cisplatin sensitivity. PMID: 17018626
    16. TUSC4/NPRL2, a novel PDK1-interacting protein, plays a role in regulating the Src/PDK1 signaling pathway and cell sensitivity to multiple cancer chemotherapeutic drugs. PMID: 18616680
    17. Our results suggest that NPRL2 mRNA expression has prognostic significance for the survival of patients with HCC. PMID: 19274676

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Epilepsy, familial focal, with variable foci 2 (FFEVF2)
  • 亞細(xì)胞定位：
    Lysosome membrane.
  • 蛋白家族：
    NPR2 family
  • 組織特異性：
    Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes. Expressed in most lung cancer
  • 數(shù)據(jù)庫鏈接：

    HGNC: 24969

    OMIM: 607072

    KEGG: hsa:10641

    STRING: 9606.ENSP00000232501

    UniGene: Hs.437083



主站蜘蛛池模板： 粗大的内捧猛烈进出少妇视频| 性裸交a片一区二区三区| 国产爆乳无码视频在线观看3| 亚洲熟妇久久国内精品| 国产69精品久久久久孕妇| 精品国产乱码久久久久久下载| 老女老肥熟国产在线视频| 女人被狂躁的高潮免费视频| 成年美女黄网站色大免费视频| 人人妻人人澡人人爽国产一区| 国产毛片毛多水多的特级毛片| 狠狠综合久久久久尤物| 国产猛烈高潮尖叫视频免费| 成年轻人电影www无码| 精品国产你懂的在线观看| 狠狠色噜噜狠狠狠狠色综合网 | 国产成年无码久久久久下载 | 在线观看国产精品va| 色欲狠狠躁天天躁无码中文字幕| 国产蜜臀av在线一区尤物| 国产免费啪嗒啪嗒视频看看 | 午夜成人理论无码电影在线播放| 日韩综合无码一区二区| 国产初高中生粉嫩无套第一次 | 欧美自拍另类欧美综合图片区| 欧美成年视频在线观看| 久久不见久久见免费影院www日本| 四库影院永久国产精品地址 | 里番本子纯肉侵犯肉全彩无码| 精品国精品国产自在久国产87| 欧美黑人xxxx又粗又长| 情侣激情18内射骚话国产 | 色婷婷五月综合激情中文字幕| 日本亚欧热亚洲乱色视频| 在线视频观看免费视频18| 日韩无码电影| 韩国乱码片免费看| 丰满少妇被猛烈进av毛片| 日韩欧美在线综合网| 九九精品成人免费国产片| 俺去啦俺来也五月天|