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  4. Recombinant Human Nitric oxide-inducible gene protein (NOXIN), partial

Recombinant Human Nitric oxide-inducible gene protein (NOXIN), partial

  • 中文名稱：
    Recombinant Human Nitric oxide-inducible gene protein(NOXIN) ,partial
  • 貨號：
    CSB-YP810293HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Nitric oxide-inducible gene protein(NOXIN) ,partial
  • 貨號：
    CSB-EP810293HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Nitric oxide-inducible gene protein(NOXIN) ,partial
  • 貨號：
    CSB-EP810293HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Nitric oxide-inducible gene protein(NOXIN) ,partial
  • 貨號：
    CSB-BP810293HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Nitric oxide-inducible gene protein(NOXIN) ,partial
  • 貨號：
    CSB-MP810293HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DDIAS
  • Uniprot No.：
  • 別名：
    Chromosome 11 open reading frame 82; DNA damage induced apoptosis suppressor; DNA damage induced apoptosis suppressor protein; FLJ13936; FLJ25416; FLJ38838; Nitric oxide inducible gene protein; Nitric oxide-inducible gene protein; Noxin; NOXIN_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

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靶點詳情

  • 功能：
    May be an anti-apoptotic protein involved in DNA repair or cell survival.
  • 基因功能參考文獻：
    1. these findings indicate that the stability of the DDIAS protein is regulated by CHIP/HSP70-mediated proteasomal degradation and that CHIP overexpression stimulates the apoptosis of lung cancer cells in response to DNA-damaging agents PMID: 28079882
    2. Noxin facilitated the expression of Cyclin D1 and Cyclin E1 through activating P38-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer PMID: 28618963
    3. EGF activates the ERK5/MEF2 pathway, which in turn induces DDIAS expression to promote cancer cell invasion by activating beta-catenin target genes PMID: 27412911
    4. DDIAS is a target of NFATc1 and is associated with cisplatin resistance in lung cancer cells. PMID: 26493727
    5. NOXIN overexpression, as a result of genomic DNA gain or amplification, promotes HCC tumorigenesis by accelerating DNA synthesis and cell cycle progression, where NOXIN functions as a cofactor of DNA polymerase-primase complex PMID: 25612832

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Highly expressed in colorectal and lung cancer tissues.
  • 數據庫鏈接：

    HGNC: 26351

    KEGG: hsa:220042

    STRING: 9606.ENSP00000414687

    UniGene: Hs.165607



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