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DDIAS Antibody

  • 中文名稱:
    DDIAS兔多克隆抗體
  • 貨號:
    CSB-PA006130
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of 823 293T AD293 Hela HepG2 cells using NOXIN Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    DDIAS
  • 別名:
    Chromosome 11 open reading frame 82 antibody; DNA damage induced apoptosis suppressor antibody; DNA damage induced apoptosis suppressor protein antibody; FLJ13936 antibody; FLJ25416 antibody; FLJ38838 antibody; Nitric oxide inducible gene protein antibody; Nitric oxide-inducible gene protein antibody; Noxin antibody; NOXIN_HUMAN antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human NOXIN.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:10000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be an anti-apoptotic protein involved in DNA repair or cell survival.
  • 基因功能參考文獻:
    1. these findings indicate that the stability of the DDIAS protein is regulated by CHIP/HSP70-mediated proteasomal degradation and that CHIP overexpression stimulates the apoptosis of lung cancer cells in response to DNA-damaging agents PMID: 28079882
    2. Noxin facilitated the expression of Cyclin D1 and Cyclin E1 through activating P38-activating transcription factor 2 signaling pathway, thus enhanced cell growth of breast cancer PMID: 28618963
    3. EGF activates the ERK5/MEF2 pathway, which in turn induces DDIAS expression to promote cancer cell invasion by activating beta-catenin target genes PMID: 27412911
    4. DDIAS is a target of NFATc1 and is associated with cisplatin resistance in lung cancer cells. PMID: 26493727
    5. NOXIN overexpression, as a result of genomic DNA gain or amplification, promotes HCC tumorigenesis by accelerating DNA synthesis and cell cycle progression, where NOXIN functions as a cofactor of DNA polymerase-primase complex PMID: 25612832

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  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 組織特異性:
    Highly expressed in colorectal and lung cancer tissues.
  • 數據庫鏈接:

    HGNC: 26351

    KEGG: hsa:220042

    STRING: 9606.ENSP00000414687

    UniGene: Hs.165607



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