在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Neurturin protein (NRTN)

Unavailable
  • 中文名稱:
    人NRTN重組蛋白
  • 貨號:
    CSB-AP002961HU
  • 規格:
    ¥6340
  • 其他:

產品詳情

  • 純度:
    >96% as determined by SDS-PAGE and HPLC.
  • 基因名:
    NRTN
  • Uniprot No.:
  • 別名:
    Neurturin; Neurturin precursor; NRTN; NRTN_HUMAN; NTN; prepro-neurturin
  • 種屬:
    Homo sapiens (Human)
  • 來源:
    E.Coli
  • 分子量:
    23.4 kDa
  • 氨基酸序列
    ARLGARPCGL RELEVRVSEL GLGYASDETV LFRYCAGACE AAARVYDLGL RRLRQRRRLR RERVRAQPCC RPTAYEDEVS FLDAHSRYHT VHELSARECA CV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    Untagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Supports the survival of sympathetic neurons in culture. May regulate the development and maintenance of the CNS. Might control the size of non-neuronal cell population such as haemopoietic cells.
  • 基因功能參考文獻:
    1. biophysical results show that the relative concentration of GFRa2 on cell surfaces can affect the functional affinity of NRTN through avidity effects. PMID: 29414779
    2. In the cochlea, NTN immunostaining was found in the supporting cells of organ of Corti, including Deiters' cells, Hensen cells as well as Claudius' cells. In the spiral ganglia, NTN was seen in both the cell bodies and the nerve fibers of neurons. PMID: 24139947
    3. Neurturin contributes toward an aggressive cancer cell phenotype, neuropathic pain and neuronal plasticity in pancreatic cancer. PMID: 24067900
    4. Human neurturin protected crayfish neurons and glia from photodynamic injury. PMID: 22847529
    5. Cyclic AMP signalling through PKA but not Epac is essential for neurturin-induced biphasic ERK1/2 activation and neurite outgrowths through GFRalpha2 isoforms. PMID: 21723942
    6. GDNF and NRTN are new neuromodulators that regulate the development of the neuromuscular synapse PMID: 11790765
    7. The gene expression of protein was studied in the developing human tooth. PMID: 12397373
    8. The results obtained suggest the involvement of NTN, PSP, and ART in processes subserving both the organization of this cortical region during development and the functional activity and maintenance of the mature human hippocampal neurons. PMID: 15829225
    9. Addition of neurturin to activated peripheral blood mononuclear leukocytes reduces the amount of detectable tumor necrosis factor protein without altering its transcription. PMID: 16081799
    10. GDNF and NTN differentially regulate the expression of distinct miRNA precursors through the activation of mitogen-activated protein kinase PMID: 16895582
    11. Depending on the brain's expressions of specific GDNF family GFRalpha2 receptor spliced isoforms, neurturin may promote or inhibit neurite outgrowth through the multicomponent receptor complex. PMID: 17522305
    12. GDNF, NTN, GFRalpha-1, GFRalpha-2, and c-Ret proteins are differentially expressed in the different stages of hair follicle cycle. GFRalpha-mediated signaling involves c-Ret and may play a role in human HF biology. PMID: 18222320
    13. No differences were found in the allelic frequencies of the variants or in the haplotype distribution between Hirschsprung's disease patients & controls, nor to any demographic/clinical parameters within the group of patients. PMID: 18970938

    顯示更多

    收起更多

  • 相關疾病:
    Genetic variations in NRTN may contribute to Hirschsprung disease, in association with mutations of RET gene, and possibly mutations in other loci. Hirschsprung disease is a disorder of neural crest development is characterized by the absence of intramural ganglion cells in the hindgut, often resulting in intestinal obstruction.
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    TGF-beta family, GDNF subfamily
  • 數據庫鏈接:

    HGNC: 8007

    OMIM: 602018

    KEGG: hsa:4902

    STRING: 9606.ENSP00000302648

    UniGene: Hs.234775



主站蜘蛛池模板: 97超碰中文字幕久久精品| 国产精品自在欧美一区| 国产高清视频一区三区| 亚洲国产精品无码久久青草| 亚洲欧美日韩综合一区在线| 奇米影视7777久久精品人人爽| 夜夜躁日日躁狠狠久久av| 精品国产精品久久一区免费式| 久久国产精品99久久久久久口爆| 国产午夜无码片在线观看网站| 嫩草伊人久久精品少妇av| 一本一道波多野结衣av一区| 国语做受对白xxxxx在线| 一本色道久久综合狠狠躁篇| 极品新婚夜少妇真紧| 九九久久精品无码专区| 中文字幕一区二区人妻电影| 久久综合九色欧美婷婷| 免费无码肉片在线观看| 亚洲精品乱码久久久久久日本| 国产亚洲精品久久久久小| 欧美性群另类交| 中文字幕中文乱码www| 精品午夜福利1000在线观看| 日本不卡一区二区三区在线| 精品国产一区二区三区久久狼| 久热这里只有精品12| 日本精品人妻无码77777| 国产午夜大地久久| 国产精品美女久久久久久福利| 欧美无遮挡很黄裸交视频| 国内精品国产三级国产av| 在线 亚洲 国产 欧美| 大伊香蕉精品视频在线直播| 精品深夜av无码一区二区| 国内裸体无遮挡免费视频| 女人摸下面自熨视频在线播放 | 99这里只有精品| 亚洲韩国日本高清一区| 国产午夜片无码区在线观看| 婷婷综合另类小说色区|