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  4. Recombinant Human Nardilysin (NRD1), partial

Recombinant Human Nardilysin (NRD1), partial

  • 中文名稱：
    人NRDC重組蛋白
  • 貨號：
    CSB-YP016075HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人NRDC重組蛋白
  • 貨號：
    CSB-EP016075HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人NRDC重組蛋白
  • 貨號：
    CSB-EP016075HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人NRDC重組蛋白
  • 貨號：
    CSB-BP016075HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人NRDC重組蛋白
  • 貨號：
    CSB-MP016075HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    NRDC
  • Uniprot No.：
  • 別名：
    NRDC; NRD1; Nardilysin; EC 3.4.24.61; N-arginine dibasic convertase; NRD convertase; NRD-C; Nardilysin convertase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
  • 基因功能參考文獻：
    1. NRDC expression was reduced in infarcted regions in autopsy samples from acute myocardial ischemia patients. PMID: 28747015
    2. Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls. PMID: 26943237
    3. MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples. PMID: 24168165
    4. This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism. PMID: 23219461
    5. possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review] PMID: 23604405
    6. SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42(IP4) show enhanced NRD protein expression already at an earlier time point after retinoic acid stimulation. PMID: 21801775
    7. NRD1 interacts with p53 mutant R273H PMID: 22653443
    8. These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha-NF-kappaB and IL-6-STAT3 signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha. PMID: 22351606
    9. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. PMID: 22294699
    10. Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively. PMID: 21703634
    11. Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1). PMID: 21972134
    12. mediates antigen processing that generates cytotoxic T cell epitopes PMID: 21151101
    13. nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF) PMID: 12095415
    14. Nardilysin has an essential role in HB-EGF ectodomain shedding, which is regulated by the modulation of sheddase activity PMID: 16923819
    15. We found high staining intensity in the hypothalamus, neocortex and brain stem nuclei. The cellular localization is almost exclusively confined to neurons. In pre- and perinatal human brain cortex, most neurons express the enzyme. PMID: 17442499
    16. These results indicate the involvement of NRDc in ectodomain shedding of TNF-alpha. PMID: 18355445
    17. Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium. PMID: 19118164
    18. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor (HB-EGF) that modulates HB-EGF-induced cell migration. PMID: 11432822
    19. The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain. PMID: 11478915

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  • 蛋白家族：
    Peptidase M16 family
  • 組織特異性：
    Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7995

    OMIM: 602651

    KEGG: hsa:4898

    STRING: 9606.ENSP00000346890

    UniGene: Hs.584782



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