在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NRDC Antibody, FITC conjugated

  • 中文名稱:
    NRDC兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA016075LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NRDC Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NRDC
  • 別名:
    NRDC antibody; NRD1 antibody; Nardilysin antibody; EC 3.4.24.61 antibody; N-arginine dibasic convertase antibody; NRD convertase antibody; NRD-C antibody; Nardilysin convertase antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Nardilysin protein (32-113AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cleaves peptide substrates on the N-terminus of arginine residues in dibasic pairs.
  • 基因功能參考文獻:
    1. NRDC expression was reduced in infarcted regions in autopsy samples from acute myocardial ischemia patients. PMID: 28747015
    2. Gene expression level of NRD1 is significantly higher in AD patients when compared to normal controls. PMID: 26943237
    3. MRNA expression of NRD1 was upregulated in 56% of ESCC tissue samples. PMID: 24168165
    4. This study demonistrated that alcohol-dependent reduction of nardilysin in cell culture and nervous tissue points to an implication of the enzyme in the pathophysiology of alcoholism. PMID: 23219461
    5. possible roles of nardilysin in Alzheimer disease, Down syndrome, schizophrenia, mood disorders, alcohol abuse, heroin addiction and cancer; show that nardilysin is a Janus-faced enzyme with regard to brain pathology-- probably neuropathogenic in some diseases, but neuroprotective in others [review] PMID: 23604405
    6. SH-SY5Y cells, stably transfected with green fluorescent protein-tagged-p42(IP4) show enhanced NRD protein expression already at an earlier time point after retinoic acid stimulation. PMID: 21801775
    7. NRD1 interacts with p53 mutant R273H PMID: 22653443
    8. These results demonstrate that gastric cancer cell growth is maintained by autonomous TNF-alpha-NF-kappaB and IL-6-STAT3 signalling, and that NRDc and ADAM proteases turn on these signalling cascades by stimulating ectodomain shedding of TNF-alpha. PMID: 22351606
    9. Identification and characterization of nardilysin as a novel dimethyl H3K4-binding protein involved in transcriptional regulation. PMID: 22294699
    10. Several flanking SNPs of the top hits in the meta-analysis demonstrated borderline associations with alcohol dependence in the family sample for KIAA0040, NRD1 and THSD7B, respectively. PMID: 21703634
    11. Tubulin potentiates the interaction of the metalloendopeptidase nardilysin with the neuronal scaffold protein p42IP4/centaurin-alpha1 (ADAP1). PMID: 21972134
    12. mediates antigen processing that generates cytotoxic T cell epitopes PMID: 21151101
    13. nardilysin (NRDc) is potently inhibited by heparin-binding epidermal growth factor-like growth factor (HB-EGF) PMID: 12095415
    14. Nardilysin has an essential role in HB-EGF ectodomain shedding, which is regulated by the modulation of sheddase activity PMID: 16923819
    15. We found high staining intensity in the hypothalamus, neocortex and brain stem nuclei. The cellular localization is almost exclusively confined to neurons. In pre- and perinatal human brain cortex, most neurons express the enzyme. PMID: 17442499
    16. These results indicate the involvement of NRDc in ectodomain shedding of TNF-alpha. PMID: 18355445
    17. Nardilysin convertase regulates the function of the maxi-K channel isoform mK44 in human myometrium. PMID: 19118164
    18. N-arginine dibasic convertase is a specific receptor for heparin-binding EGF-like growth factor (HB-EGF) that modulates HB-EGF-induced cell migration. PMID: 11432822
    19. The acidic stretch of nardilysin, expressed as a fusion protein with glutathione S-transferase and compared to the native enzyme with respect to spermine binding, functions as an autonomous domain. PMID: 11478915

    顯示更多

    收起更多

  • 蛋白家族:
    Peptidase M16 family
  • 組織特異性:
    Primarily in adult heart, skeletal muscle, and testis and at much lower levels in other tissues.
  • 數據庫鏈接:

    HGNC: 7995

    OMIM: 602651

    KEGG: hsa:4898

    STRING: 9606.ENSP00000346890

    UniGene: Hs.584782



主站蜘蛛池模板: 成 年 人 黄 色 大 片大 全| 国产精品久久久久永久免费看| 国产成人精品日本亚洲77上位| 国产精品无码日韩欧| 久久久天堂国产精品女人| 久99久热只有精品国产女同| 午夜伦4480yy私人影院久久| 2018av无码视频在线播放| 伊人久久精品无码二区麻豆| 日本熟妇人妻xxxx| 国产69精品久久久久久久| 国产精品亚洲精品日韩已满十八小| 欧美亚洲日本国产黑白配| 亚洲国产精品久久久久网站| 成人免费无码大片a毛片小说| 亚洲国产精品久久久久婷婷老年| 日韩欧美一区二区三区免费观看 | 亚洲第一成人网站在线播放| 亚洲αv无码一区二区三区四区| 玩弄丰满熟妇xxxxx性60| 在线观看免费视频网站a站| av无码av天天av天天爽| 欧美精品videosex性欧美| 国产极品美女到高潮| 亚洲国产成人精品福利| 久久www成人影院| 国产内射爽爽大片| 日韩人妻无码一区二区三区| 久久精品丝袜高跟鞋| 亚洲成av人片不卡无码久久| 国产精品嫩草99av在线| 久久大香国产成人av| 免费又黄又爽又色的视频| 丰满的人妻hd高清日本| 国内精品美女a∨在线播放| 日韩中文字幕在线专区| 无码无套少妇毛多18pxxxx| 国产网友自拍在线视频| 免费无码午夜福利片| 九九热久久只有精品2| 国产成人无码a区在线观看视频 |