在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human NEDD4 family-interacting protein 1 (NDFIP1), partial

  • 中文名稱:
    人NDFIP1重組蛋白
  • 貨號:
    CSB-YP887119HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人NDFIP1重組蛋白
  • 貨號:
    CSB-EP887119HU1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人NDFIP1重組蛋白
  • 貨號:
    CSB-EP887119HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人NDFIP1重組蛋白
  • 貨號:
    CSB-BP887119HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人NDFIP1重組蛋白
  • 貨號:
    CSB-MP887119HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    NDFIP1
  • Uniprot No.:
  • 別名:
    NDFIP1; N4WBP5; PSEC0192; PSEC0223; NEDD4 family-interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation. Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion. Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC. Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells. Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation. In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity. Important for normal development of dendrites and dendritic spines in cortex. Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1. Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity.
  • 基因功能參考文獻:
    1. we identified Nedd4-family interacting protein 1 as a direct target of miR-155, and the expression of Nedd4-family interacting protein 1 was inhibited by miR-155. Furthermore, ectopic expression of Nedd4-family interacting protein 1 restored the effects of miR-155 on cell proliferation and invasion of uveal melanoma cells PMID: 29333944
    2. the expression of Ndfipl reduced expression of a-synuclein. In conclusion, Ndfipl plays a significant role in protecting SH-SY5Y cells in in vitro Parkinson's disease models. PMID: 27173227
    3. Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin secretion. These effects were associated with an increase in the cellular content of JunB, a potent inhibitor of ER stress and apoptosis. PMID: 26319551
    4. Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus. PMID: 25631046
    5. In Parkinson's disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes. PMID: 24475238
    6. Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes. PMID: 21187286
    7. Ndfip1 is required for the exosomal secretion of Nedd4 family proteins PMID: 18819914
    8. Ndfip1 plays a critical role in regulating metal transport in human neurons through its regulation of DMT1. PMID: 19706893

    顯示更多

    收起更多

  • 亞細胞定位:
    Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Cell junction, synapse, synaptosome. Cell projection, dendrite. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway (PubMed:18819914).
  • 組織特異性:
    Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 17592

    OMIM: 612050

    KEGG: hsa:80762

    STRING: 9606.ENSP00000253814

    UniGene: Hs.653510



主站蜘蛛池模板: 久久国产精品无码一区二区三区| 精品日韩亚洲欧美高清a| 欧美大波少妇在厨房被| 国产欧美一区二区精品久久久| 国精品无码人妻一区二区三区| 亚洲午夜无码久久久久蜜臀av| 精品999日本久久久影院| 日韩精品射精管理在线观看| 夜夜影院未满十八勿进| 成人看片黄a免费看在线| 国产超碰女人任你爽| 五月综合激情婷婷六月色窝| 超碰97人人射妻| 日日碰狠狠躁久久躁2023| 国产精品自在线一区| 欧美熟妇色ⅹxxx欧美妇| 亚洲乱亚洲乱少妇无码99p| 麻豆精品一卡二卡三卡| 国产成人理论无码电影网| 国产丝袜视频一区二区三区| 少妇白浆高潮无码免费区| 国产色青青视频在线观看撒| 亚洲国产成人一区二区三区| 久久久久久久综合色一本 | 麻豆文化传媒精品一区观看| 97精品国产久热在线观看| 亚洲午夜精品久久久久久浪潮| 精品人妻人人做人人爽| 色婷婷六月亚洲婷婷丁香| 丰满少妇人妻hd高清大乳在线| 久久精品国产69国产精品亚洲 | 无码人妻一区二区三区免费看成人| 国产精品 无码专区| 日本亚洲欧美在线视观看| 国产午夜成人免费看片app| 忍不住的亲子中文字幕| 亚洲中文字幕永久在线不卡| 国产老熟女狂叫对白| 国产毛片欧美毛片久久久| 亚洲日韩片无码中文字幕| 情侣激情18内射骚话国产|