在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

NDFIP1 Antibody, HRP conjugated

  • 中文名稱:
    NDFIP1兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA887119LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) NDFIP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    NDFIP1
  • 別名:
    NDFIP1; N4WBP5; PSEC0192; PSEC0223; NEDD4 family-interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human NEDD4 family-interacting protein 1 protein (2-116AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation. Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion. Restricts the production of proinflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC. Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination. Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells. Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation. In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity. Important for normal development of dendrites and dendritic spines in cortex. Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1. Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH. Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate. Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity.
  • 基因功能參考文獻:
    1. we identified Nedd4-family interacting protein 1 as a direct target of miR-155, and the expression of Nedd4-family interacting protein 1 was inhibited by miR-155. Furthermore, ectopic expression of Nedd4-family interacting protein 1 restored the effects of miR-155 on cell proliferation and invasion of uveal melanoma cells PMID: 29333944
    2. the expression of Ndfipl reduced expression of a-synuclein. In conclusion, Ndfipl plays a significant role in protecting SH-SY5Y cells in in vitro Parkinson's disease models. PMID: 27173227
    3. Silencing of Ndfip1 inhibited cytokine-induced apoptosis of pancreatic islets and promoted glucose-stimulated insulin secretion. These effects were associated with an increase in the cellular content of JunB, a potent inhibitor of ER stress and apoptosis. PMID: 26319551
    4. Ndfip1 is required during stress for ubiquitinating and trafficking BRAT1 into the nucleus. PMID: 25631046
    5. In Parkinson's disease, increased iron levels are associated with increased Ndfip1 expression for the regulation of DMT1, including abnormal Ndfip1 activation in non-neuronal cell types such as astrocytes. PMID: 24475238
    6. Cellular up-regulation of Nedd4 family interacting protein 1 (Ndfip1) using low levels of bioactive cobalt complexes. PMID: 21187286
    7. Ndfip1 is required for the exosomal secretion of Nedd4 family proteins PMID: 18819914
    8. Ndfip1 plays a critical role in regulating metal transport in human neurons through its regulation of DMT1. PMID: 19706893

    顯示更多

    收起更多

  • 亞細胞定位:
    Endosome membrane; Multi-pass membrane protein. Golgi apparatus membrane. Cell junction, synapse, synaptosome. Cell projection, dendrite. Secreted. Note=Detected in exosomes and secreted via the exosomal pathway (PubMed:18819914).
  • 組織特異性:
    Widely expressed. Higher levels are detected in cerebellum, pituitary, thalamus, kidney, liver, testis, salivary glands and placenta. Also expressed in fetal brain, kidney and lung.
  • 數據庫鏈接:

    HGNC: 17592

    OMIM: 612050

    KEGG: hsa:80762

    STRING: 9606.ENSP00000253814

    UniGene: Hs.653510



主站蜘蛛池模板: 欧美老妇与禽交| 无码不卡av东京热毛片| 45分钟免费真人视频| 肥臀浪妇太爽了快点再快点 | 18成禁人视频免费| 久久爱www人成狠狠爱综合网| 人妻出差精油按摩被中出| 成人福利国产精品视频| 午夜福利伦伦电影理论片在线观看 | 色悠久久久久久久综合网伊人| 欧美人与禽猛交狂配| 极品美女在线观看免费直播| 2021少妇久久久久久久久久| 97国产色伦在色在线播放| 国产成人无码a区视频在线观看| 精品国产乱码久久久久久郑州公司 | 欧美日韩亚洲国产欧美电影| 无码国产69精品久久久孕妇| 久久婷婷五月综合色一区二区| 国产精品多p对白交换绿帽| 国产av一区二区三区无码野战| 国产精品白丝喷浆| 国产美女久久久亚洲综合| 成人午夜精品无码区久久| 午夜福利国产成人无码gif动图 | 久久精品a亚洲国产v高清不卡| 狠狠做深爱婷婷丁香综合| 国产杨幂丝袜av在线播放| 大战丰满无码人妻50p| 欧美做爰性生交视频| 一性一交一口添一摸视频| 人妻护士在线波多野结衣| 久久成人网站亚洲综合| 98久9在线 | 免费| 中国亚洲女人69内射少妇| 久久精品中文无码资源站| 韩国无码色视频在线观看| 亚洲精品一区久久久久| 97久久国产亚洲精品超碰热 | 色中色成人导航| 国产色视频一区二区三区|