Recombinant Human N-lysine methyltransferase SETD6 (SETD6)

中文名稱：

人SETD6重組蛋白
貨號(hào)：

CSB-YP855042HU
規(guī)格：
來(lái)源：

Yeast
其他：

中文名稱：

人SETD6重組蛋白
貨號(hào)：

CSB-EP855042HU
規(guī)格：
來(lái)源：

E.coli
其他：

中文名稱：

人SETD6重組蛋白
貨號(hào)：

CSB-EP855042HU-B
規(guī)格：
來(lái)源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

人SETD6重組蛋白
貨號(hào)：

CSB-BP855042HU
規(guī)格：
來(lái)源：

Baculovirus
其他：

中文名稱：

人SETD6重組蛋白
貨號(hào)：

CSB-MP855042HU
規(guī)格：
來(lái)源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
相關(guān)產(chǎn)品
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

SETD6
Uniprot No.：

Q8TBK2
別名：

SETD6; N-lysine methyltransferase SETD6; EC 2.1.1.-; SET domain-containing protein 6
種屬：

Homo sapiens (Human)
蛋白長(zhǎng)度：

full length protein
表達(dá)區(qū)域：

1-473
氨基酸序列

MATQAKRPRV AGPVDGGDLD PVACFLSWCR RVGLELSPKV SERAGGRRTR GGARAALTSP PAQVAVSRQG TVAGYGMVAR ESVQAGELLF VVPRAALLSQ HTCSIGGLLE RERVALQSQS GWVPLLLALL HELQAPASRW RPYFALWPEL GRLEHPMFWP EEERRCLLQG TGVPEAVEKD LANIRSEYQS IVLPFMEAHP DLFSLRVRSL ELYHQLVALV MAYSFQEPLE EEEDEKEPNS PVMVPAADIL NHLANHNANL EYSANCLRMV ATQPIPKGHE IFNTYGQMAN WQLIHMYGFV EPYPDNTDDT ADIQMVTVRE AALQGTKTEA ERHLVYERWD FLCKLEMVGE EGAFVIGREE VLTEEELTTT LKVLCMPAEE FRELKDQDGG GDDKREEGSL TITNIPKLKA SWRQLLQNSV LLTLQTYATD LKTDQGLLSN KEVYAKLSWR EQQALQVRYG QKMILHQLLE LTS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4.
基因功能參考文獻(xiàn)：
1. WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration PMID: 30226578
2. Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. PMID: 28973356
3. High SETD6 expression is associated with bladder cancer. PMID: 28122346
4. PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway. PMID: 26841865
5. these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin. PMID: 26780326
6. Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation. PMID: 24751716
7. SETD6 monomethylates H2AZ on lysine 7. PMID: 23324626
8. methylation of the NF-kappaB results in repression of NF-kappaB signaling PMID: 21131967
9. SETD6 mono-methylate Rela on K310 and negatively regulates RelA transcription activity PMID: 21131967
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亞細(xì)胞定位：

Nucleus.
蛋白家族：

Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SETD6 subfamily
數(shù)據(jù)庫(kù)鏈接：

HGNC: 26116

OMIM: 616424

KEGG: hsa:79918

STRING: 9606.ENSP00000219315

UniGene: Hs.731691