在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SETD6 Antibody, Biotin conjugated

SETD6 Antibody, Biotin conjugated

  • 中文名稱：
    SETD6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA855042LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SETD6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SETD6
  • 別名：
    SETD6 antibody; N-lysine methyltransferase SETD6 antibody; EC 2.1.1.- antibody; SET domain-containing protein 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human N-lysine methyltransferase SETD6 protein (1-74AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4.
  • 基因功能參考文獻：
    1. WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration PMID: 30226578
    2. Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. PMID: 28973356
    3. High SETD6 expression is associated with bladder cancer. PMID: 28122346
    4. PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway. PMID: 26841865
    5. these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin. PMID: 26780326
    6. Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation. PMID: 24751716
    7. SETD6 monomethylates H2AZ on lysine 7. PMID: 23324626
    8. methylation of the NF-kappaB results in repression of NF-kappaB signaling PMID: 21131967
    9. SETD6 mono-methylate Rela on K310 and negatively regulates RelA transcription activity PMID: 21131967

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SETD6 subfamily
  • 數據庫鏈接：

    HGNC: 26116

    OMIM: 616424

    KEGG: hsa:79918

    STRING: 9606.ENSP00000219315

    UniGene: Hs.731691



主站蜘蛛池模板： 亚洲精品美女久久久久99| 亚洲精品nv久久久久久久久久| 乱妇乱女熟妇熟女网站| 国产好爽…又高潮了毛片| 久久久精品妇女99| 日本xxxx片免费观看| 日韩精品一区二区三区在线观看| 中文字幕精品一区二区精品| 国产精品久久久久久爽爽爽床戏| 美女露出粉嫩小奶头在视频18禁| 女人扒开屁股桶爽30分钟| 国产精品-区区久久久狼| 国产成人av国语在线观看| 伊人久久大香线蕉无码不卡| 中文无码乱人伦中文视频在线v| 久久国产欧美日韩精品图片| 国内永久福利在线视频图片| av无码欧洲亚洲电影网| 999久久欧美人妻一区二区| 欧美成人va免费看视频| 色又黄又爽18禁免费网站| 国产又色又爽又刺激在线播放 | 亚洲精品蜜桃久久久久久| 欧美亚洲日本国产综合在线| 97久久超碰中文字幕| 人妻少妇精品久久久久久| 国产大屁股视频免费区| 高潮爽死抽搐白浆gif视频| 国产交换配乱婬视频| 成在线人免费无码高潮喷水| 精品国产丝袜自在线拍国语| 人妻中文乱码在线网站| 最新精品香蕉在线| 一线二线无人区乱码| 午夜性刺激在线视频免费| 少妇激情一区二区三区视频小说| 日本三级理论久久人妻电影| 成人污污污www网站免费| 国产妇女馒头高清泬20p多| 日本强伦姧人妻一区二区| 男人的天堂免费一区二区视频|