在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. SETD6 Antibody, Biotin conjugated

SETD6 Antibody, Biotin conjugated

  • 中文名稱：
    SETD6兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA855042LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) SETD6 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    SETD6
  • 別名：
    SETD6 antibody; N-lysine methyltransferase SETD6 antibody; EC 2.1.1.- antibody; SET domain-containing protein 6 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human N-lysine methyltransferase SETD6 protein (1-74AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulation of NF-kappa-B transcription factor activity. Monomethylates 'Lys-8' of H2AZ (H2AZK8me1). Required for the maintenance of embryonic stem cell self-renewal. Methylates PAK4.
  • 基因功能參考文獻：
    1. WDR5 was identified as a substrate of SETD6 and it was revealed that the methylation of specific lysines (K207/K325) of WDR5 was critical for maintaining global histone H3K4me3 levels and promoting breast cancer cell proliferation and migration PMID: 30226578
    2. Findings suggest that the identified mutation impairs the normal function of SETD6, which may result in the deregulation of the different pathways in which it is involved, contributing to the increased susceptibility to cancer in this FCCTX family. PMID: 28973356
    3. High SETD6 expression is associated with bladder cancer. PMID: 28122346
    4. PAK4 methylation by SETD6 promotes the activation of the Wnt/beta-catenin pathway. PMID: 26841865
    5. these findings demonstrate that SETD6 negatively regulates the Nrf2-mediated oxidative stress response through a physical and catalytically independent interaction with DJ1 at chromatin. PMID: 26780326
    6. Several chromatin proteins that associate with SETD6 are identified and SETD6 is described as an essential factor for nuclear receptor signaling and cellular proliferation. PMID: 24751716
    7. SETD6 monomethylates H2AZ on lysine 7. PMID: 23324626
    8. methylation of the NF-kappaB results in repression of NF-kappaB signaling PMID: 21131967
    9. SETD6 mono-methylate Rela on K310 and negatively regulates RelA transcription activity PMID: 21131967

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Class V-like SAM-binding methyltransferase superfamily, Histone-lysine methyltransferase family, SETD6 subfamily
  • 數據庫鏈接：

    HGNC: 26116

    OMIM: 616424

    KEGG: hsa:79918

    STRING: 9606.ENSP00000219315

    UniGene: Hs.731691



主站蜘蛛池模板： 成人做爰www网站视频| 精品国产一区二区三区av色诱| 最新在线精品国自产拍视频 | 99re在线播放| 亚洲日韩一区二区三区| 亚洲精品亚洲人成在线| 日本妇人成熟免费视频| 高清国产亚洲欧洲av综合一区| 日韩中文亚洲欧美视频二| 无套内谢的新婚少妇国语播放 | 亚洲最大的成人网| 玩弄japan白嫩少妇hd| 久久精品国产99国产精2020丨| 成人做爰视频www网站| 亚洲精品久久久久久久蜜桃臀| 国产大屁股喷水视频在线观看| 欧美熟妇丰满肥白大屁股免费视频| 国产成人a∨麻豆精品| 精品国产天堂综合一区在线| 国产精品爽爽久久久久久蜜臀| 夜夜爱夜夜做夜夜爽| 欧美精品九九久久久久久久久| 国产亚洲人成网站在线观看| 精品无码专区毛片| 国产无套内射久久久国产| 国内大量揄拍人妻精品視頻| 精品系列无码一区二区三区| 太粗太深了太紧太爽了动态图男男| 中文字幕人妻中文av不卡专区| 国产免费一区二区视频| 大香伊蕉在人线国产最新75| 中文字幕亚洲码在线| 无遮挡又黄又刺激的视频| 中文天堂在线www最新版官网| 少妇熟女久久综合网色欲| 天天摸天天做天天爽水多| 亚洲精品国产品国语在线| 国产精品亚洲а∨天堂网| 亚洲欧美不卡高清在线| 99re6在线视频精品免费下载 | 99久久国产宗和精品1上映|