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  4. Recombinant Human N-acetyltransferase ESCO1 (ESCO1), partial

Recombinant Human N-acetyltransferase ESCO1 (ESCO1), partial

  • 中文名稱：
    人ESCO1重組蛋白
  • 貨號：
    CSB-YP708021HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ESCO1重組蛋白
  • 貨號：
    CSB-EP708021HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ESCO1重組蛋白
  • 貨號：
    CSB-EP708021HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ESCO1重組蛋白
  • 貨號：
    CSB-BP708021HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ESCO1重組蛋白
  • 貨號：
    CSB-MP708021HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ESCO1
  • Uniprot No.：
  • 別名：
    A930014I12Rik; CTF; CTF7 homolog 1; CTF7; S. cerevisiae; homolog of; 1; ECO1; ECO1 homolog 1; ECO1; S. cerevisiae; homolog of; 1; EFO1; EFO1p; ESCO1; ESCO1_HUMAN; ESO1; ESO1 homolog 1; ESO1; S. pombe; homolog of; 1; Establishment factor like protein 1; Establishment factor ortholog 1; Establishment factor-like protein 1; Establishment of cohesion 1 homolog 1; Establishment of cohesion 1; S. cerevisiae; homolog of; establishment of sister chromatid cohesion N-acetyltransferase 1; hEFO1; HGNC:24645; KIAA1911; N acetyltransferase ESCO1; N-acetyltransferase ESCO1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acetyltransferase required for the establishment of sister chromatid cohesion. Couples the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
  • 基因功能參考文獻：
    1. Data indicate that Esco1 and Esco2 contribute to distinct and separable activities of cohesin in vertebrate cells. PMID: 28847955
    2. these studies reveal the molecular basis for SMC3 acetylation by ESCO1 and have broader implications for understanding the structure/function of non-histone acetyltransferases. PMID: 27803161
    3. our findings indicated that ESCO1 may play an important role in human bladder cancer, and ESCO1 might serve as a novel target and prognosis factor for human bladder cancer. PMID: 26547586
    4. By interacting with a unique domain of Esco1, Pds5 recruits Esco1 to chromatin-bound cohesin complexes to form cohesion. PMID: 26051894
    5. Data show that acetyltransferase Esco1 colocalizes with cohesin throughout the cell cycle and down-regulates expression of neighboring genes. PMID: 26305936
    6. this is the first evidence that Eco1 represses transcription by interacting with histone demethylase, LSD1 to convert chromatin to inactive state. PMID: 20331966
    7. Variants in ESCO1 is associated with predisposition for TMPRSS2-ERG fusion in prostate cancer. PMID: 19861517
    8. identification of the first full-length human ortholog of yeast Ctf7p and characterization of its enzymatic activity, localization and novel genetic composition PMID: 14576321
    9. EFO1 and EFO2 are targeted to different chromosome structures to help establish or maintain sister-chromatid cohesion PMID: 15958495
    10. This study identified a molecular target for the acetyltransferase Eco1 and revealed that Smc3 acetylation is a conserved mechanism in regulating sister chromatid cohesion. PMID: 18614053

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  • 亞細胞定位：
    Nucleus. Chromosome.
  • 蛋白家族：
    Acetyltransferase family, ECO subfamily
  • 組織特異性：
    Widely expressed. Expressed in heart, brain, liver, placenta, lung, kidney and pancreas. Highly expressed in muscle.
  • 數據庫鏈接：

    HGNC: 24645

    OMIM: 609674

    KEGG: hsa:114799

    STRING: 9606.ENSP00000269214

    UniGene: Hs.464733



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