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  4. Recombinant Human Myosin-10 (MYH10), partial

Recombinant Human Myosin-10 (MYH10), partial

  • 中文名稱：
    人MYH10重組蛋白
  • 貨號：
    CSB-YP015290HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MYH10重組蛋白
  • 貨號：
    CSB-EP015290HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MYH10重組蛋白
  • 貨號：
    CSB-EP015290HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MYH10重組蛋白
  • 貨號：
    CSB-BP015290HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MYH10重組蛋白
  • 貨號：
    CSB-MP015290HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cellular myosin heavy chain; Cellular myosin heavy chain type B; Cellular myosin heavy chain type B type B; MGC134913; MGC134914; MYH 10; Myh10; MYH10_HUMAN; Myosin 10; Myosin heavy chain 10; Myosin heavy chain 10 non muscle; Myosin heavy chain; Myosin heavy chain non muscle 11b; Myosin heavy chain nonmuscle IIb; Myosin heavy chain nonmuscle type B; Myosin heavy polypeptide 10 non muscle; Myosin-10; Myosin10; NMMHC B; NMMHC II b; NMMHC II-b; NMMHC IIB; NMMHC-B; NMMHC-IIB; NMMHCB; Non muscle myosin heavy chain B; Non muscle myosin heavy chain IIB; Non muscle myosin II heavy chain B; non-muscle IIb; Non-muscle myosin heavy chain B; Non-muscle myosin heavy chain IIb; Nonmuscle myosin heavy chain B; Nonmuscle myosin heavy chain IIB; Nonmuscle myosin II heavy chain B; Nonmuscle myosin IIB; type B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. Involved with LARP6 in the stabilization of type I collagen mRNAs for CO1A1 and CO1A2. During cell spreading, plays an important role in cytoskeleton reorganization, focal contacts formation (in the central part but not the margins of spreading cells), and lamellipodial extension; this function is mechanically antagonized by MYH9.
  • 基因功能參考文獻：
    1. cellular quiescence induces Mec17 to couple the production of acetylated microtubules and Myh10, whose accumulation overcomes the inhibitory role of Myh9 and initiates ciliogenesis PMID: 25494100
    2. We identify three mosaic missense and likely-gene disrupting mutations in genes previously implicated in ASD (KMT2C, NCKAP1, and MYH10) in probands but none in siblings. We find a strong ascertainment bias for mosaic mutations in probands relative to their unaffected siblings PMID: 27632392
    3. A receptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway was identified as responsible for recruiting myosin IIB to the zonula adherens in epithelial cells and supporting contractile tension. PMID: 25631816
    4. Our results indicate that MYH10 contributes to ciliogenesis in RPE1 cells by promoting cortical actin-dependent centriole migration. PMID: 25881509
    5. The role of nonmuscle myosin II (NMII)-B in front-back migratory cell polarity is controlled by a short stretch of amino acids containing five serines. PMID: 25869664
    6. The findings suggest that elevated NMHCIIb levels contribute to meningioma tumor formation and progression. PMID: 24858044
    7. Supervillin concentrates activated and total myosin II at the furrow, and simultaneous knockdown of supervillin and anillin additively increases cell division failure. PMID: 24088567
    8. The myosin-IIB is unpolarized in cells on soft matrix in 2D and also within soft 3D collagen, with rearward polarization of MIIB emerging only as cells migrate from soft to stiff matrix. PMID: 23128239
    9. MYH10 detection is associated with inherited platelet disorders and myeloid neoplasms with abnormalities in RUNX1 and FLI1. PMID: 22677128
    10. Data show that inhibition of non-muscle myosin II ATPase by blebbistatin completely blocks enucleation of human erythroblasts; results suggest that NMMHC-IIB is synthesized in erythroblasts and is required for erythroblast enucleation. PMID: 22049517
    11. In the context of inflammation, myeloid cells may limit axonal repair in the central nervous system via a myosin II-dependent mechanism. PMID: 21737147
    12. a signaling complex containing c-Cbl and myosin IIA plays a crucial role in blebbing and macropinocytosis during viral infection in KSHV infection. PMID: 21203488
    13. Data suggest that myosin-II and ERM proteins modulate mechanical properties in oocytes, contributing to cell polarity and to completion of meiosis. PMID: 20660156
    14. Data conclude that P-cadherin counteracts the expression and function of myosin II-B, resulting in the suppression of the invasive and migratory behaviour of BLM melanoma cells. PMID: 20860798
    15. Data suggest a role for NM IIB in TNFR1 endocytosis and the formation of the death inducing signaling complex (DISC). PMID: 20564232
    16. analysis of kinetic mechanism of non-muscle myosin IIB PMID: 12704189
    17. anillin has a role in spatially regulating the contractile activity of myosin II during cytokinesis PMID: 15496454
    18. In leukocytes, the activity of non-muscle myosin II is essential for cell migration, and it is not essential for tumor cell migration. PMID: 15619008
    19. Assessment of solubility of a series of truncated recombinant rod fragments of nonmuscle myosin IIB at various concentrations of NaCl. PMID: 15628858
    20. mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C PMID: 15845534
    21. SMemb/NMMHC-B is expressed in proliferating smooth muscle cells and correlates with phenotypic changes from a contractive to a proliferative type. The stromal cells of the prostate play a role in the regulation of prostatic growth and function. PMID: 16257837
    22. These results indicate that PKCgamma regulates NMHC-IIB phosphorylation and cellular localization in response to EGF stimulation. PMID: 16394101
    23. Myosin II-B resides in a complex with p21-activated kinase 1 (PAK1) and atypical protein kinase C (PKC) zeta (aPKCzeta) and the interaction between these proteins is EGF-dependent. PMID: 16611744
    24. estrogen increases NMM-II-B MgATPase activity independent of NMM-II-B filamentation status PMID: 17023528
    25. The N-terminal 57 residues (N-57) and C-terminal 63 residues (C-63) of C-terminal 305-residue rod fragment of the myosin IIB heavy chain (BRF305) are involved in self-recognition when myosin IIB molecules assemble into homo-filament. PMID: 17202408
    26. downregulation of myosin II-B, the major myosin isoform in neurons, is able to increase Abeta deposition, concomitantly altering the subcellular localization of APP PMID: 17727819
    27. MHC expression profile in the CXMDJ diaphragm differed from that in mdx mice. This indicates the dystrophic dog is a more appropriate model to investiagte respiratory failure in dystrophin deficiency. PMID: 18182116
    28. We conclude that myosin II regulates the spherical shape of epithelial cysts by controlling actin polymerization at the cyst surface. PMID: 18460584
    29. cMyBP-C phosphorylation is necessary for basal myocardial function in the beta-MyHC background and can preserve function after ischemia/reperfusion injury PMID: 19237661
    30. Myosin II tailpiece determines its paracrystal structure, filament assembly properties, and cellular localization PMID: 19553683

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  • 相關疾病：
    Associated with severe intellectual disability, microcephaly, and feeding difficulties as well as cerebral atrophy.
  • 亞細胞定位：
    Cell projection, lamellipodium. Note=Colocalizes with MCC at the leading edge of migrating cells.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 組織特異性：
    Isoform 1 is expressed in cerebellum and spinal chord. Isoform 2 is expressed in cerebrum and retina. Isoform 3 is expressed in the cerebrum and to a much lower extent in cerebellum.
  • 數據庫鏈接：

    HGNC: 7568

    OMIM: 160776

    KEGG: hsa:4628

    STRING: 9606.ENSP00000269243

    UniGene: Hs.16355



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