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  4. Recombinant Human Myopalladin (MYPN), partial

Recombinant Human Myopalladin (MYPN), partial

  • 中文名稱：
    人MYPN重組蛋白
  • 貨號：
    CSB-YP015378HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MYPN重組蛋白
  • 貨號：
    CSB-EP015378HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MYPN重組蛋白
  • 貨號：
    CSB-EP015378HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MYPN重組蛋白
  • 貨號：
    CSB-BP015378HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MYPN重組蛋白
  • 貨號：
    CSB-MP015378HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MYPN
  • Uniprot No.：
  • 別名：
    145 kDa sarcomeric protein; MYOP; Myopalladin; MYPN; MYPN_HUMAN; sarcomeric protein myopalladin
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點詳情

  • 功能：
    Component of the sarcomere that tethers together nebulin (skeletal muscle) and nebulette (cardiac muscle) to alpha-actinin, at the Z lines.
  • 基因功能參考文獻：
    1. Targeted sequencing revealed trigenic mutations: c.700G>A/p.E234K in DES, c.2966G>A/p.R989H in MYPN, and c.5918G>C/p.R1973P in CACNA1C in a family of hypertrophic cardiomyopathy with early repolarization and short QT syndrome. PMID: 28427417
    2. Homozygous truncating mutations in MYPN in 2 unrelated families with a slowly progressive congenital cap myopathy. PMID: 28220527
    3. results suggest that MYPN screening should be considered in individuals with mild nemaline myopathy, especially when cardiac problems or intranuclear rods are present PMID: 28017374
    4. Heterozygote Mypn(WT/Q526X) knock-in mice develop RCM due to persistence of mutant Mypn(Q526X) protein in the nucleus. PMID: 25541130
    5. the clinical significance of myopalladin for the functional integrity of the sarcomeric apparatus and the protection against dilated cardiomyopathy PMID: 22892539
    6. Two nonsense and 13 missense MYPN variants were identified in subjects with hypertrophic, dilated and/or restrictive cardiomyopathy. PMID: 22286171
    7. mutations in PDLIM3 and MYPN are infrequent in hypertrophic cardiomyopathies PMID: 20801532
    8. myopalladin plays a signaling role in targeting and orienting nebulin during sarcomere assembly PMID: 12482578
    9. myopalladin gene is a new gene associated with dilated cardiomyopathy and observed mutations in 3-4% of cases in a population. of European descent. PMID: 18006477

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  • 相關(guān)疾病：
    Nemaline myopathy 11 (NEM11); Cardiomyopathy, dilated 1KK (CMD1KK); Cardiomyopathy, familial hypertrophic 22 (CMH22); Cardiomyopathy, familial restrictive 4 (RCM4)
  • 亞細胞定位：
    Cytoplasm. Nucleus. Cytoplasm, myofibril, sarcomere. Cytoplasm, myofibril, sarcomere, Z line.
  • 蛋白家族：
    Myotilin/palladin family
  • 組織特異性：
    Expressed in adult skeletal muscle and fetal heart.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 23246

    OMIM: 608517

    KEGG: hsa:84665

    STRING: 9606.ENSP00000351790

    UniGene: Hs.55205



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