在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Muscarinic acetylcholine receptor M4 (CHRM4), partial

  • 中文名稱:
    Recombinant Human Muscarinic acetylcholine receptor M4(CHRM4),partial
  • 貨號:
    CSB-YP005384HU1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human Muscarinic acetylcholine receptor M4(CHRM4),partial
  • 貨號:
    CSB-EP005384HU1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human Muscarinic acetylcholine receptor M4(CHRM4),partial
  • 貨號:
    CSB-EP005384HU1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human Muscarinic acetylcholine receptor M4(CHRM4),partial
  • 貨號:
    CSB-BP005384HU1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human Muscarinic acetylcholine receptor M4(CHRM4),partial
  • 貨號:
    CSB-MP005384HU1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CHRM4; Muscarinic acetylcholine receptor M4
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is inhibition of adenylate cyclase.
  • 基因功能參考文獻:
    1. the association of the African-specific CHRM4 SNP with cocaine dependence survived correction for multiple testing PMID: 27269905
    2. This study identify suppression of the PVHSIM1-->PAGvl/DR circuit connection as sufficient to induce overeating behavior. PMID: 24768300
    3. Data indicate that compounds derived from VU0152100 showed M4 muscarinic receptor (M4 mAChR) direct agoinst properties. PMID: 24074052
    4. The data of this study suggested that the rs2067482 polymorphism may help to predict susceptibility to schizophrenia and/or therapeutic responsiveness. PMID: 23490763
    5. Use of HM4- and green fluorescent protein-expressing trangenic mice as tissue donors in cell-based therapy validates a rodent model of Huntington disease. PMID: 21295605
    6. analysis of allosteric agonism and modulation at the M4 muscarinic acetylcholine receptor PMID: 20406819
    7. relative to other muscarinic receptor subtypes, the M(4) receptor could be the subtype which is selectively compromised in Alzeheimer's disease PMID: 12505680
    8. M4 increases expression of "migratory" integrins; M4 effects resulted from inhibition of the inhibitory pathway involving the adenylyl cyclase-cyclic AMP-protein kinase A pathway PMID: 15263021
    9. In progressive supranuclear palsy: there were no changes in M4 muscarinic receptor density PMID: 18282687
    10. Regions in i3 including Leu272-Arg338 and Val373-Ala393 are involved in internalization of the M4 receptor; the region including Val373-Ala393 is indispensable for its recycling, whereas the other regions are dispensable for internalization and recycling. PMID: 18337477

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family, Muscarinic acetylcholine receptor subfamily, CHRM4 sub-subfamily
  • 數據庫鏈接:

    HGNC: 1953

    OMIM: 118495

    KEGG: hsa:1132

    STRING: 9606.ENSP00000409378

    UniGene: Hs.248100



主站蜘蛛池模板: 亚洲人av在线无码影院观看| 欧美老妇交乱视频在线观看| 美女露全乳无遮掩视频| 日产精品一区2区卡四卡二卡| 奇米777狠狠色噜噜狠狠狠| 亚洲欧美第一成人网站7777| 成人做受黄大片| 日本道色综合久久影院| 国产日韩未满十八禁止观看| 国产日产欧产精品网站| 国产欧美一区二区精品性色| 成年男人裸j照无遮挡无码| 一本一本久久a久久综合精品| 亚洲va在线∨a天堂va欧美va| 国产精品人妻一区二区三区四 | 久久国产精品免费一区二区三区| 亚洲国产精品高清久久久| 亚洲日本精品国产一区vr| 成人无码视频| 狠狠色噜噜狠狠狠狠色综合久| 又黄又粗又爽免费观看| 性色香蕉av久久久天天网| 精品久久久无码人妻字幂| 亚洲福利国产网曝| 中文字幕精品亚洲无线码vr | 香蕉av福利精品导航| 国产在线无码一区二区三区| 天堂av成年av影视| 国产xxx69麻豆国语对白| 久久久精品2020免费观看| 69风韵老熟女口爆吞精| 亚洲成a人片在线观看无码| 欧美破苞系列二十三| 成年网站未满十八禁视频天堂| 亚洲中文字幕无码久久2018| 精品人妻人人做人人爽| 在线岛国片免费无码av| 日本xxxx18野外无毒不卡| 国产97色在线 | 亚洲| 国产精品被窝福利一区| 国产女人叫床高潮大片|