在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁(yè)
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU)

Recombinant Human Mitochondrial tRNA-specific 2-thiouridylase 1 (TRMU)

  • 中文名稱：
    人TRMU重組蛋白
  • 貨號(hào)：
    CSB-YP024545HU
  • 規(guī)格：
  • 來(lái)源：
    Yeast
  • 其他：
  • 中文名稱：
    人TRMU重組蛋白
  • 貨號(hào)：
    CSB-EP024545HU
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 其他：
  • 中文名稱：
    人TRMU重組蛋白
  • 貨號(hào)：
    CSB-EP024545HU-B
  • 規(guī)格：
  • 來(lái)源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人TRMU重組蛋白
  • 貨號(hào)：
    CSB-BP024545HU
  • 規(guī)格：
  • 來(lái)源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人TRMU重組蛋白
  • 貨號(hào)：
    CSB-MP024545HU
  • 規(guī)格：
  • 來(lái)源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TRMU
  • Uniprot No.：
  • 別名：
    LCAL3; MGC99627; Mitochondrial tRNA specific 2 thiouridylase 1; Mitochondrial tRNA-specific 2-thiouridylase 1; MTO 2; MTO2; MTO2 homolog; MTU 1; MTU1; MTU1_HUMAN; TRMT 1; TRMT; trmu; tRNA (5 methylaminomethyl 2 thiouridylate) methyltransferase; tRNA 5 methylaminomethyl 2 thiouridylate methyltransferase; TRNT 1; TRNT1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長(zhǎng)度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-421
  • 氨基酸序列
    MQALRHVVCA LSGGVDSAVA ALLLRRRGYQ VTGVFMKNWD SLDEHGVCTA DKDCEDAYRV CQILDIPFHQ VSYVKEYWND VFSDFLNEYE KGRTPNPDIV CNKHIKFSCF FHYAVDNLGA DAIATGHYAR TSLEDEEVFE QKHVKKPEGL FRNRFEVRNA VKLLQAADSF KDQTFFLSQV SQDALRRTIF PLGGLTKEFV KKIAAENRLH HVLQKKESMG MCFIGKRNFE HFLLQYLQPR PGHFISIEDN KVLGTHKGWF LYTLGQRANI GGLREPWYVV EKDSVKGDVF VAPRTDHPAL YRDLLRTSRV HWIAEEPPAA LVRDKMMECH FRFRHQMALV PCVLTLNQDG TVWVTAVQAV RALATGQFAV FYKGDECLGS GKILRLGPSA YTLQKGQRRA GMATESPSDS PEDGPGLSPL L
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.
  • 基因功能參考文獻(xiàn)：
    1. The A10S mutation caused marked decreases in 2-thiouridine modification of U34 of tRNA(Lys), tRNA(Glu) and tRNA(Gln) However, the A10S mutation mildly increased the aminoacylated efficiency of tRNAs PMID: 28049726
    2. Results show that post-transcriptional expression of GTPBP3, MTO1 and TRMU genes is down-regulated, leading to mt-tRNA hypomodification and contributing to mitochondrial dysfunction in MELAS cybrids. PMID: 25149473
    3. An additional, heterozygous mutation was detected in TRMU/MTU1. Although subject myoblasts and myotubes contained half the normal levels of TRMU, thiolation of mitochondrial tRNAs was normal. PMID: 22504945
    4. MTU1 is not required for mitochondrial translation. PMID: 21890497
    5. identification and characterization of a tRNA-modifying enzyme MTU1 (mitochondrial tRNA-specific 2-thiouridylase 1) that is responsible for the 2-thiolation of the wobble position in human and yeast mt tRNAs PMID: 15509579
    6. MTO2 may act as a modifier gene, modulating the phenotypic expression of the deafness-associated A1491G or C1409T mutation in mitochondrial 12 S rRNA PMID: 15944150
    7. These observations suggest that human TRMU may modulate the phenotypic manifestation of the deafness-associated mitochondrial 12S rRNA mutations. PMID: 16513084
    8. The mutated TRMU, related to transfer RNA modification, acting as a modifier factor modulates the phenotypic manifestation of deafness-associated 12S rRNA mutations. PMID: 16826519
    9. TRMU G28T single nucleotide polymorphism is present in 1 of the studied families for neurosensory nonsyndromic deafness PMID: 18391568
    10. There is a window of time whereby patients with TRMU mutations are at increased risk of developing liver failure. PMID: 19732863
    11. Identification and characterization of a mouse gene encoding one component of the enzyme complex responsible for the nucleotide modification at wobble position of mitochondrial tRNA anticodons. PMID: 14746906

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Liver failure, infantile, transient (LFIT)
  • 亞細(xì)胞定位：
    Mitochondrion.
  • 蛋白家族：
    MnmA/TRMU family
  • 組織特異性：
    Ubiquitous. Abundantly expressed in tissues with high metabolic rates including heart, liver, kidney, and brain.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 25481

    OMIM: 580000

    KEGG: hsa:55687

    STRING: 9606.ENSP00000290846

    UniGene: Hs.439524



主站蜘蛛池模板： 黄网在线观看免费网站| 97se亚洲国产综合在线| 欧美人与动牲交xxxxbbbb| 成在人线av无码免费看| 无码免费毛片手机在线| 国产精品无码综合区| 极品少妇扒开粉嫩小泬视频| 国产日韩综合av在线观看一区 | 久久99精品久久久久久齐齐 | 亚洲日本va午夜中文字幕一区| 99热久久这里只有精品| 暖暖 免费 高清 日本 在线| 亚洲性无码av在线| 亚洲精品偷拍影视在线观看 | 欧美亅性猛交内射| 免费国产成人高清在线观看网站| 亚洲欧美日韩综合av| 亚洲精品久久一区二区三区777| 亚洲国产精品成人一区二区在线| 真人做人试看60分钟免费视频| 成人午夜福利院在线观看| 国产美女遭强高潮网站下载| 九九精品无码专区免费| 全部免费毛片在线播放| 国产性猛交╳xxx乱大交| 欧洲日本一线二线三线区本庄铃| 国产精品免费视频色拍拍| 久久久久久久久888| 国产成人久久精品77777综合| 青青草av一区二区三区| 亚洲成av人在线观看天堂无码| 亚洲综合成人av一区在线观看| 无码av一区二区三区无码| 亚洲欧美日本韩国| 久久久久国产精品人妻aⅴ牛牛| 亚洲精品午夜一区二区电影院| 欧美丰满熟妇xxxx性| 亚洲鲁丝片一区二区三区| 中文字幕无码人妻丝袜| 熟妇的奶头又大又长奶水视频| 精品国产亚洲一区二区三区 |