在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Mini-chromosome maintenance complex-binding protein (MCMBP)

  • 中文名稱:
    人MCMBP重組蛋白
  • 貨號:
    CSB-YP880100HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人MCMBP重組蛋白
  • 貨號:
    CSB-EP880100HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人MCMBP重組蛋白
  • 貨號:
    CSB-EP880100HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人MCMBP重組蛋白
  • 貨號:
    CSB-BP880100HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人MCMBP重組蛋白
  • 貨號:
    CSB-MP880100HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    MCMBP
  • Uniprot No.:
  • 別名:
    MCMBP; C10orf119; Mini-chromosome maintenance complex-binding protein; MCM-BP; MCM-binding protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-642
  • 氨基酸序列
    MPCGEDWLSH PLGIVQGFFA QNGVNPDWEK KVIEYFKEKL KENNAPKWVP SLNEVPLHYL KPNSFVKFRC MIQDMFDPEF YMGVYETVNQ NTKAHVLHFG KYRDVAECGP QQELDLNSPR NTTLERQTFY CVPVPGESTW VKEAYVNANQ ARVSPSTSYT PSRHKRSYED DDDMDLQPNK QKDQHAGARQ AGSVGGLQWC GEPKRLETEA STGQQLNSLN LSSPFDLNFP LPGEKGPACL VKVYEDWDCF KVNDILELYG ILSVDPVLSI LNNDERDASA LLDPMECTDT AEEQRVHSPP ASLVPRIHVI LAQKLQHINP LLPACLNKEE SKTCKFVSSF MSELSPVRAE LLGFLTHALL GDSLAAEYLI LHLISTVYTR RDVLPLGKFT VNLSGCPRNS TFTEHLYRII QHLVPASFRL QMTIENMNHL KFIPHKDYTA NRLVSGLLQL PSNTSLVIDE TLLEQGQLDT PGVHNVTALS NLITWQKVDY DFSYHQMEFP CNINVFITSE GRSLLPADCQ IHLQPQLIPP NMEEYMNSLL SAVLPSVLNK FRIYLTLLRF LEYSISDEIT KAVEDDFVEM RKNDPQSITA DDLHQLLVVA RCLSLSAGQT TLSRERWLRA KQLESLRRTR LQQQKCVNGN EL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
  • 基因功能參考文獻:
    1. the MCMBP protein accumulates to high levels in cancer cells, whereas in normal proliferating tissue its abundance is low, indicating that MCMBP could be exploited as a novel diagnostic marker for this type of carcinoma. PMID: 25246271
    2. Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins. PMID: 24190967
    3. results suggest that MCM-BP makes multiple contributions to human cells that are not limited to unloading of the MCM complex PMID: 22250201
    4. MCM-BP can decrease phosphorylation by DDK but is not a substrate. PMID: 22540012
    5. MCM-BP silencing in human cells also delays MCM dissociation in late S phase PMID: 21196493
    6. Knockdown of the human ETG1 results in defective chromatid cohesion. PMID: 20090939
    7. MCM-BP is conserved in multicellular eukaryotes and shares limited homology with MCM proteins. MCM-BP formed a complex with MCM3 to MCM7, which excluded MCM2. PMID: 17296731

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
  • 蛋白家族:
    MCMBP family
  • 數據庫鏈接:

    HGNC: 25782

    OMIM: 610909

    KEGG: hsa:79892

    STRING: 9606.ENSP00000353098

    UniGene: Hs.124246



主站蜘蛛池模板: 亚洲精品久久久久久中文| 亚洲精品国产自在久久| 成人欧美一区二区三区视频| 自拍偷自拍亚洲精品情侣| 日韩成人一区二区三区在线观看| 国产精品嫩草影院av| 欧美日韩精品无码一本二本三本色 | 久久人妻国产精品31| 天天狠天天透天天伊人| 性xxxx搡xxxxx搡欧美| 色欲色香天天天综合无码| 欧洲无线码免费一区| 国产精品久久久久久久久久妞妞 | 亚洲熟妇色自偷自拍另类| 欧美亚洲日韩国产网站| 亚洲在av极品无码| а天堂中文在线官网在线 | 国产高清无密码一区二区三区| 国产成人一区二区三区别| 狠狠色狠狠色综合网老熟女| 国产 日韩 中文字幕 制服| 啦啦啦www在线观看免费视频| 欧美性videos高清精品| 亚洲性无码一区二区三区| 亚洲精品国产av现线| 亚洲精品久久久久久久蜜桃| 国产美女无遮挡裸色视频| 日韩亚洲国产综合高清 | 天天躁日日躁狠狠躁| 末成年毛片在线播放| 最新日韩精品中文字幕| 国产日韩综合一区二区性色av| 日本免费一区二区三区日本| 久久国产高潮流白浆免费观看| 小妖精又紧又湿高潮h视频69| 久久亚洲精品成人av无码网站| 小小拗女性bbwxxxx国产| 国产又黄又大又粗视频| 人妻少妇精品无码专区二区| 久久精品国产久精国产果冻传媒| 国产大学生粉嫩无套流白浆|