在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MCMBP Antibody

MCMBP Antibody

  • 中文名稱：
    MCMBP兔多克隆抗體
  • 貨號：
    CSB-PA002918GA01HU
  • 規格：
    ￥3,900
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    MCMBP
  • 別名：
    MCMBP antibody; C10orf119 antibody; Mini-chromosome maintenance complex-binding protein antibody; MCM-BP antibody; MCM-binding protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human C10orf119
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.
  • 基因功能參考文獻：
    1. the MCMBP protein accumulates to high levels in cancer cells, whereas in normal proliferating tissue its abundance is low, indicating that MCMBP could be exploited as a novel diagnostic marker for this type of carcinoma. PMID: 25246271
    2. Data indicate that MCM-BP binds USP7 on chromatin and can mediate an interaction between the USP7 and MCM proteins. PMID: 24190967
    3. results suggest that MCM-BP makes multiple contributions to human cells that are not limited to unloading of the MCM complex PMID: 22250201
    4. MCM-BP can decrease phosphorylation by DDK but is not a substrate. PMID: 22540012
    5. MCM-BP silencing in human cells also delays MCM dissociation in late S phase PMID: 21196493
    6. Knockdown of the human ETG1 results in defective chromatid cohesion. PMID: 20090939
    7. MCM-BP is conserved in multicellular eukaryotes and shares limited homology with MCM proteins. MCM-BP formed a complex with MCM3 to MCM7, which excluded MCM2. PMID: 17296731

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Note=Associates with chromatin. Highly associated with chromatin in G1/S and S phases, reduced binding to chromatin in G2, and further decreased binding in early M phase. It then reassociates with chromatin in late M phase. Dissociates from chromatin later than component of the MCM complex.
  • 蛋白家族：
    MCMBP family
  • 數據庫鏈接：

    HGNC: 25782

    OMIM: 610909

    KEGG: hsa:79892

    STRING: 9606.ENSP00000353098

    UniGene: Hs.124246



主站蜘蛛池模板： 成人av一本不卡二卡| √最新版天堂资源在线| 精品麻豆丝袜高跟鞋av| 欧美性猛交xxxx三人| 无码精品黑人一区二区三区 | 久久九九国产精品怡红院| 国产精品国产三级国产专区53| 国产乱人伦app精品久久| 色综合av综合无码综合网站| 国产高清-国产av| 99热成人精品热久久| 国产一线二线三线女| 国产精品成人久久电影| 又爽又黄又无遮挡网站| 久久婷婷人人澡人人爽人人爱| 麻豆妓女爽爽一区二区三| 老司机午夜福利视频| 久久综合给合久久狠狠狠88| 亚洲精品国产自在现线最新| 中文字幕 人妻熟女| 欧美内射深插日本少妇| 饥渴少妇av无码影片| 国产欧美国日产高清| 丰满人妻被黑人猛烈进入| 国产产无码乱码精品久久鸭| 亚洲综合色区另类小说| 99久久久国产精品消防器材| 青春草在线视频观看| 男人撕开奶罩揉吮奶头视频| 国内芒果精品自线一区2021| 免费女人高潮流视频在线观看| 在线天堂中文在线资源网| 免费国产在线一区二区| 无码视频免费一区二区三区| 少妇太爽了在线观看| 无码人妻品一区二区三区精99| 日韩国产精品人妻无码久久久| 色偷偷偷在线视频播放| 韩国三级中文字幕hd久久精品| 五月综合缴情婷婷六月| 国产人妻人伦精品1国产盗摄 |