在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Methyl-CpG-binding domain protein 3 (MBD3)

Recombinant Human Methyl-CpG-binding domain protein 3 (MBD3)

  • 中文名稱：
    人MBD3重組蛋白
  • 貨號：
    CSB-YP013532HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MBD3重組蛋白
  • 貨號：
    CSB-EP013532HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MBD3重組蛋白
  • 貨號：
    CSB-EP013532HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MBD3重組蛋白
  • 貨號：
    CSB-BP013532HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MBD3重組蛋白
  • 貨號：
    CSB-MP013532HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MBD3
  • Uniprot No.：
  • 別名：
    AI181826; AU019209; MBD 3; Mbd3; MBD3: methyl CpG binding domain protein 3; MBD3_HUMAN; Methyl CpG binding domain protein 3; Methyl CpG binding protein MBD3; Methyl-CpG-binding domain protein 3; Methyl-CpG-binding protein MBD3
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-291
  • 氨基酸序列
    MERKRWECPA LPQGWEREEV PRRSGLSAGH RDVFYYSPSG KKFRSKPQLA RYLGGSMDLS TFDFRTGKML MSKMNKSRQR VRYDSSNQVK GKPDLNTALP VRQTASIFKQ PVTKITNHPS NKVKSDPQKA VDQPRQLFWE KKLSGLNAFD IAEELVKTMD LPKGLQGVGP GCTDETLLSA IASALHTSTM PITGQLSAAV EKNPGVWLNT TQPLCKAFMV TDEDIRKQEE LVQQVRKRLE EALMADMLAH VEELARDGEA PLDKACAEDD DEEDEEEEEE EPDPDPEMEH V
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases.
  • 基因功能參考文獻：
    1. Study have demonstrated that MBD3/ NuRD inhibits formation of liver induced cancer stem cells (iCSCs). In addition, MBD3 suppression induces c-JUN, resulting in the induction of pluripotent genes in iCSCs. PMID: 27894081
    2. Suggest that MBD3 exerts influences on both active and silenced genes in glioma cells. PMID: 27835581
    3. MBD3 inhibits epithelial-mesenchymal transition in pancreatic cancer cells probably via TGF-beta/Smad signaling and may be a candidate for diagnostics and prognosis of pancreatic cancer. PMID: 27898661
    4. Overexpression of MBD3 is associated with neoplasms. PMID: 27465550
    5. Insufficient MBD3 induced by small interfering RNA (siRNA) was found to result in a global DNA hypermethylation as well as increased methylation in the promoter CpG islands (CGIs) of a number of cell cycle related genes. PMID: 25753672
    6. This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia. PMID: 24849540
    7. These data suggest that MBD3, and by extension the NuRD complex, may have multiple roles in fine tuning expression for both active and silent genes, representing an important step in defining regulatory mechanisms PMID: 24385926
    8. reduced mRNA expression of MBD2 and MBD3 is implicated in gastric carcinogenesis. PMID: 24338710
    9. MBD3 is enriched at active promoters, whereas MBD2 is bound at methylated promoters and enriched at exon sequences of active genes. PMID: 23361464
    10. These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 homologues (MBD2 approximately MBD3 > MBD3L1 approximately MBD3L2). PMID: 23239876
    11. MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome. PMID: 20004753
    12. MBD3 is highly expressed in glioblastome multiforme compared to astrocytoma and anaplastic astrocytoma PMID: 11836615
    13. interaction with two highly related p66 proteins PMID: 12183469
    14. localization in Aurora-A-positive centrosomes in M phase PMID: 12354758
    15. MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing PMID: 15701600
    16. MBD3 assembles into mutually exclusive distinct Mi-2/NuRD-like complex, called MBD3/NuRD. PMID: 16428440
    17. This is the first demonstration that MBD3 is involved in inducing and maintaining the demethylated state of a specific promoter. PMID: 17452452
    18. data demonstrate a causal relationship between MBD3 and DNA demethylation of genomic targets in cells. PMID: 18602768
    19. Study demonstrates a direct role of the MBD3, a subunit of nucleosome remodeling and deacetylase corepressor complex complex in aberrant gene repression and transmission of epigenetic repressive marks in acute promyelocytic leukemia. PMID: 18644863
    20. These findings collectively support a role for MBD3 in cell cycle progression and cell death as a modulator of HDAC-mediated transcription. PMID: 19041848

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
  • 數據庫鏈接：

    HGNC: 6918

    OMIM: 603573

    KEGG: hsa:53615

    STRING: 9606.ENSP00000156825

    UniGene: Hs.178728



主站蜘蛛池模板： 在线观看人成视频免费| 久久久精品456亚洲影院| 亚洲色成人一区二区三区| 免费网站观看www在线观看| 中文字幕在线免费看线人| 精品国产a∨无码一区二区三区| 国内高清久久久久久| 亚洲国产精品久久久久爰| 人妻熟妇乱又伦精品视频无广告 | 97久久国产成人免费网站| 青青热久免费精品视频| 国产高颜值大学生情侣酒店| 亚洲精品久久久久久无码色欲四季| 最新国产精品好看的精品| 亚洲va综合va国产产va中| 亚洲中文字幕久久精品无码喷水| 中文字幕日韩精品一区二区三区| 在线观看日本亚洲一区| 亚洲色无码专区一区| 欧美18videosex性欧美黑吊 | 国内无遮挡18禁无码网站免费| 日韩一区二区三区四区区区| 国产jk精品白丝av在线观看| 中文字日产幕乱五区| 欧美熟妇乱子伦xx视频| 日本xxxx片免费观看| 51国偷自产一区二区三区| 亚洲精品国产av天美传媒| 日本工口里番无遮█彩色| 国产一区二区三精品久久久无广告 | 成年日韩片av在线网站| 中文成人无码精品久久久动漫 | 无码少妇一区二区三区芒果| 香蕉97超级碰碰碰免费公开| 国产性色αv视频免费| 欧美成人精品手机在线| 国产亚洲精aa在线观看不卡| 国产卡一卡二无线乱码| 一本一道人人妻人人妻αv| 国产va免费精品高清在线| 亚洲成a人v电影在线观看 |