在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MBD3 Antibody

MBD3 Antibody

  • 中文名稱(chēng)：
    MBD3兔多克隆抗體
  • 貨號(hào)：
    CSB-PA693569
  • 規(guī)格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from Jurkat cells, using MBD3 antibody.
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng)：
    Rabbit anti-Homo sapiens (Human) MBD3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MBD3
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from C-terminal of Human MBD3.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類(lèi)型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as transcriptional repressor and plays a role in gene silencing. Does not bind to DNA by itself. Binds to DNA with a preference for sites containing methylated CpG dinucleotides (in vitro). Binds to a lesser degree DNA containing unmethylated CpG dinucleotides. Recruits histone deacetylases and DNA methyltransferases.
  • 基因功能參考文獻(xiàn)：
    1. Study have demonstrated that MBD3/ NuRD inhibits formation of liver induced cancer stem cells (iCSCs). In addition, MBD3 suppression induces c-JUN, resulting in the induction of pluripotent genes in iCSCs. PMID: 27894081
    2. Suggest that MBD3 exerts influences on both active and silenced genes in glioma cells. PMID: 27835581
    3. MBD3 inhibits epithelial-mesenchymal transition in pancreatic cancer cells probably via TGF-beta/Smad signaling and may be a candidate for diagnostics and prognosis of pancreatic cancer. PMID: 27898661
    4. Overexpression of MBD3 is associated with neoplasms. PMID: 27465550
    5. Insufficient MBD3 induced by small interfering RNA (siRNA) was found to result in a global DNA hypermethylation as well as increased methylation in the promoter CpG islands (CGIs) of a number of cell cycle related genes. PMID: 25753672
    6. This study investigates the genetic association between methyl-CpG-binding domain (MBD) gene polymorphisms and schizophrenia. PMID: 24849540
    7. These data suggest that MBD3, and by extension the NuRD complex, may have multiple roles in fine tuning expression for both active and silent genes, representing an important step in defining regulatory mechanisms PMID: 24385926
    8. reduced mRNA expression of MBD2 and MBD3 is implicated in gastric carcinogenesis. PMID: 24338710
    9. MBD3 is enriched at active promoters, whereas MBD2 is bound at methylated promoters and enriched at exon sequences of active genes. PMID: 23361464
    10. These factors lead to a binding affinity hierarchy of p66alpha for the different MBD2 homologues (MBD2 approximately MBD3 > MBD3L1 approximately MBD3L2). PMID: 23239876
    11. MBD3 mutations are not responsible for ICR1 hypomethylation in Silver-Russell syndrome. PMID: 20004753
    12. MBD3 is highly expressed in glioblastome multiforme compared to astrocytoma and anaplastic astrocytoma PMID: 11836615
    13. interaction with two highly related p66 proteins PMID: 12183469
    14. localization in Aurora-A-positive centrosomes in M phase PMID: 12354758
    15. MBD3L2 interacts with MBD3 and components of the NuRD complex and can oppose MBD2-MeCP1-mediated methylation silencing PMID: 15701600
    16. MBD3 assembles into mutually exclusive distinct Mi-2/NuRD-like complex, called MBD3/NuRD. PMID: 16428440
    17. This is the first demonstration that MBD3 is involved in inducing and maintaining the demethylated state of a specific promoter. PMID: 17452452
    18. data demonstrate a causal relationship between MBD3 and DNA demethylation of genomic targets in cells. PMID: 18602768
    19. Study demonstrates a direct role of the MBD3, a subunit of nucleosome remodeling and deacetylase corepressor complex complex in aberrant gene repression and transmission of epigenetic repressive marks in acute promyelocytic leukemia. PMID: 18644863
    20. These findings collectively support a role for MBD3 in cell cycle progression and cell death as a modulator of HDAC-mediated transcription. PMID: 19041848

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Nucleus. Chromosome. Note=Nuclear, in discrete foci. Detected on chromatin, at promoter regions of active genes.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 6918

    OMIM: 603573

    KEGG: hsa:53615

    STRING: 9606.ENSP00000156825

    UniGene: Hs.178728



主站蜘蛛池模板： 亚洲熟妇色xxxxx亚洲| 国产成人精品视频ⅴa片软件竹菊| 午夜无码一区二区三区在线观看| 少妇暴力深喉囗交3p| 在线看片免费人成视频影院看 | 日韩欧美亚洲综合久久影院d3| 国产精品午夜视频自在拍| 国产精品免费大片| 欧美一区二区三区激情| 欧美黑人巨大videos在线| 免费无码又爽又刺激毛片| 亚洲愉拍自拍欧美精品| 色翁荡息又大又硬又粗又爽| 男人边吻奶边挵进去视频| 伊人久久精品无码麻豆一区| 亚洲精品99久久久久中文字幕| 国产精品成人久久久久久久| 亚洲美女高清aⅴ视频免费| 亚洲精品99久久久久久欧美版| 欧美日韩精品一区二区在线播放| 欧美肥熟妇xxxxx| 国产免费福利在线视频| 韩国三级中文字幕hd| 成人区人妻精品一区二区不卡视频| 精品久久欧美熟妇www| 97夜夜澡人人爽人人模人人喊| 国产中文字字幕乱码无限| 久久不见久久见免费影院www日本 99久久无色码中文字幕 | 少妇人妻在线视频| 亚洲免费人成在线视频观看| 波多野结衣乱码中文字幕| 中文字幕无线码成人免费看| 全部孕妇毛片丰满孕妇孕交| 狠狠做深爱婷婷丁香综合 | 亚洲成av人片在线播放无码| 色 亚洲 日韩 国产 综合| 国产午夜亚洲精品久久| 国产 | 欧洲野花视频天堂视频p| 精品国产乱码久久久久久鸭王1| 中文字幕人妻被公上司喝醉在线| 热re99久久6国产精品免费|