在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor (MANF)

Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor (MANF)

  • 中文名稱：
    人MANF重組蛋白
  • 貨號：
    CSB-YP002118HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MANF重組蛋白
  • 貨號：
    CSB-EP002118HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MANF重組蛋白
  • 貨號：
    CSB-EP002118HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MANF重組蛋白
  • 貨號：
    CSB-BP002118HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MANF重組蛋白
  • 貨號：
    CSB-MP002118HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MANF
  • Uniprot No.：
  • 別名：
    Arginine rich mutated in early stage tumors; Arginine rich protein; Arginine-rich protein; ARMET; ARMET protein; ARP; Manf; MANF_HUMAN; Mesencephalic astrocyte derived neurotrophic factor; Mesencephalic astrocyte-derived neurotrophic factor; MGC142148; MGC142150; Protein ARMET
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    25-182
  • 氨基酸序列
    LRPGDC EVCISYLGRF YQDLKDRDVT FSPATIENEL IKFCREARGK ENRLCYYIGA TDDAATKIIN EVSKPLAHHI PVEKICEKLK KKDSQICELK YDKQIDLSTV DLKKLRVKEL KKILDDWGET CKGCAEKSDY IRKINELMPK YAPKAASART DL
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
  • 基因功能參考文獻：
    1. Our data indicate that increased MANF concentrations in serum are associated with the clinical manifestation of type 1 diabetes in children, but the exact mechanism behind the increase remains elusive PMID: 27356471
    2. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death. PMID: 29497057
    3. Serum MANF level was higher in patients with newly diagnosed prediabetes and T2 Diabetes Mellitus than in normal glucose tolerance controls. MANF appears to be associated with Matsuda Index, QUICKI and HOMA-IR in prediabetes patients. PMID: 28216543
    4. the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied. PMID: 26720341
    5. the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation. PMID: 26429332
    6. MANF is a protein that interacts with RTN1-C PMID: 25543119
    7. We demonstrate that Armet and Creld2 are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 is a key disease trigger in MED that could be exploited as a potential therapeutic target PMID: 23956175
    8. MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface. PMID: 23255601
    9. MANF and C-MANF protect neurons intracellularly as efficiently as Ku70. PMID: 21047780
    10. Pretreatment with adeno-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats. PMID: 20685313
    11. Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response. PMID: 18561914
    12. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types. PMID: 18718866
    13. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain PMID: 19258449

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen.
  • 蛋白家族：
    ARMET family
  • 數據庫鏈接：

    HGNC: 15461

    OMIM: 601916

    KEGG: hsa:7873

    STRING: 9606.ENSP00000432799

    UniGene: Hs.436446



主站蜘蛛池模板： 国产精品久免费的黄牛仔短裤| 免费无码成人片| 黑人大战中国av女叫惨了| 国产粉嫩嫩00在线正在播放| av性色av久久无码ai换脸| 无码成a毛片免费| 1000部啪啪未满十八勿入下载| 成 人 亚洲 综合天堂| 久久亚洲道色宗和久久| 伊人精品成人久久综合97| 日韩精品一区二区三区视频| 99久久国产综合精品swag| 爽死你欧美大白屁股在线| 在线 | 国产精品99传媒丿| 人妻在卧室被老板疯狂进入| 中文字幕日韩精品一区二区三区| 久青草国产97香蕉在线影院| www一区二区乱码www| 欧美丰满熟妇xxxx性ppx人交 | 2020精品国产自在现线看| 亚洲国产欧美在线人成大黄瓜| 牲高潮99爽久久久久777| 少妇扒开腿让我爽了一夜| 久久精品久久电影免费理论片 | 男人的好看免费观看在线视频| 末成年毛片在线播放| 亚洲精品久久久久午夜福禁果tⅴ 国产精品无码久久久久久 | 国产av无码精品色午夜| 18禁免费无码无遮挡不卡网站| 国产真实伦对白全集| 国产免费无遮挡吸乳视频在线观看| 无码一区二区三区久久精品| 国产女主播白浆在线观看| 国产区又黄又硬高潮的视频| 亚洲人精品亚洲人成在线| 欧美人妻aⅴ中文字幕| 人妻换人妻仑乱| 丁香婷婷无码不卡在线| 亚洲风影视传媒有限公司辽宁| 奇米影视第4色| 亚洲中文久久精品无码照片|