在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. MANF Antibody

MANF Antibody

  • 中文名稱：
    MANF兔多克隆抗體
  • 貨號：
    CSB-PA002118ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA002118ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA002118ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) MANF Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    MANF
  • 別名：
    Arginine rich mutated in early stage tumors antibody; Arginine rich protein antibody; Arginine-rich protein antibody; ARMET antibody; ARMET protein antibody; ARP antibody; Manf antibody; MANF_HUMAN antibody; Mesencephalic astrocyte derived neurotrophic factor antibody; Mesencephalic astrocyte-derived neurotrophic factor antibody; MGC142148 antibody; MGC142150 antibody; Protein ARMET antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Mesencephalic astrocyte-derived neurotrophic factor protein (25-182AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons. Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death. Retained in the ER/sarcoplasmic reticulum (SR) through association with the endoplasmic reticulum chaperone protein HSPA5 under normal conditions. Up-regulated and secreted by the ER/SR in response to ER stress and hypoxia. Following secretion by the ER/SR, directly binds to 3-O-sulfogalactosylceramide, a lipid sulfatide in the outer cell membrane of target cells. Sulfatide binding promotes its cellular uptake by endocytosis, and is required for its role in alleviating ER stress and cell toxicity under hypoxic and ER stress conditions.
  • 基因功能參考文獻：
    1. Our data indicate that increased MANF concentrations in serum are associated with the clinical manifestation of type 1 diabetes in children, but the exact mechanism behind the increase remains elusive PMID: 27356471
    2. Sulfatide binding promotes cellular MANF uptake and cytoprotection from hypoxia-induced cell death. PMID: 29497057
    3. Serum MANF level was higher in patients with newly diagnosed prediabetes and T2 Diabetes Mellitus than in normal glucose tolerance controls. MANF appears to be associated with Matsuda Index, QUICKI and HOMA-IR in prediabetes patients. PMID: 28216543
    4. the role of two short sequence motifs within the carboxy-(C) terminal domain of MANF in its neuroprotective activity, was studied. PMID: 26720341
    5. the selective expression of MANF in splenocytes may be involved in plasma cell differentiation and immune regulation. PMID: 26429332
    6. MANF is a protein that interacts with RTN1-C PMID: 25543119
    7. We demonstrate that Armet and Creld2 are genotype-specific ER stress response proteins with substrate specificities, and that aggregation of mutant matrilin-3 is a key disease trigger in MED that could be exploited as a potential therapeutic target PMID: 23956175
    8. MANF binding to the plasma membrane also required the RTDL sequence and was inhibited with a peptide known to interact with KDELRs, suggesting MANF binds KDELRs at the surface. PMID: 23255601
    9. MANF and C-MANF protect neurons intracellularly as efficiently as Ku70. PMID: 21047780
    10. Pretreatment with adeno-associated-virus vector containing human MANF reduces the volume of cerebral infarction and facilitates behavioral recovery in experimental stroke rats. PMID: 20685313
    11. Armet is a novel secreted mediator of the adaptive pathway of unfolded protein response. PMID: 18561914
    12. The widespread expression of MANF together with its evolutionary conserved nature and regulation by brain insults suggest that it has important functions both under normal and pathological conditions in many tissue types. PMID: 18718866
    13. structures of MANF and CDNF were solved; structure explains why MANF and CDNF are bifunctional; neurotrophic activity may reside in the N-terminal domain and ER stress response in the C-terminal domain PMID: 19258449

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Endoplasmic reticulum lumen. Sarcoplasmic reticulum lumen.
  • 蛋白家族：
    ARMET family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15461

    OMIM: 601916

    KEGG: hsa:7873

    STRING: 9606.ENSP00000432799

    UniGene: Hs.436446



主站蜘蛛池模板： 人人做人人爽国产视| 免费无码成人av片在线| 亚洲国产品综合人成综合网站| 免费国产午夜视频在线观看| 99re久久精品国产首页| 国产精品午夜无码av体验区| 国产成人无码综合亚洲日韩| 久久香蕉国产线看观看怡红院妓院| 国内精品久久久久影院蜜芽| 亚洲一卡2卡3卡4卡5卡精品| 欧美变态口味重另类在线视频 | 国产口爆吞精在线视频| 欧美片内射欧美美美妇| 国产亚洲精品自在久久蜜tv | 久久综合给合久久狠狠狠97色 | 男女性爽大片视频免费看| 国产日产欧产精品品不卡| 五月丁香六月综合av| 亚洲欧美日本韩国| 亚洲国产专区校园欧美| 在线 | 国产精品99传媒丿| 国产ww久久久久久久久久| 秋霞在线观看秋| 欧美牲交a欧美牲交aⅴ另类| 国产精品亚洲玖玖玖在线观看| 久草热久草热线频97精品| 国产成人一区二区三区| 国产精品一区二区久久精品 | 伊人久久大香线蕉亚洲| 亚洲国产剧情中文视频在线| 韩国主播av福利一区二区| 丰满人妻一区二区三区免费视频| 国产成人精品综合在线观看| 亚洲综合小说专区图片| 丁香五月激情综合亚洲| 少妇富婆高级按摩出水高潮 | 国产精品二区一区二区aⅴ污介绍| 无码成人aaaaa毛片| 加勒比无码人妻东京热| 国产av偷闻女邻居内裤被发现| 无码人妻aⅴ一区二区三区69岛|