在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Meprin A subunit beta (MEP1B), partial

Recombinant Human Meprin A subunit beta (MEP1B), partial

  • 中文名稱：
    人MEP1B重組蛋白
  • 貨號：
    CSB-YP618098HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MEP1B重組蛋白
  • 貨號：
    CSB-EP618098HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MEP1B重組蛋白
  • 貨號：
    CSB-EP618098HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MEP1B重組蛋白
  • 貨號：
    CSB-BP618098HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MEP1B重組蛋白
  • 貨號：
    CSB-MP618098HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MEP1B
  • Uniprot No.：
  • 別名：
    Endopeptidase 2 ; Endopeptidase-2; kinase splitting membranal proteinase; KSMP; Mep1b; MEP1B_HUMAN; Meprin 1 beta subunit; Meprin A beta; Meprin A beta subunit precursor; Meprin A subunit beta; Meprin B; N benzoyl L tyrosyl P amino benzoic acid hydrolase beta subunit; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta; PABA peptide hydrolase; PPH beta
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
  • 基因功能參考文獻：
    1. Results provide evidence that meprin beta is involved in collagen deposition in vivo in the lung of bleomycin treated mice and it localized in region with immature collagen. This suggests that meprin beta can favor the progression of the fibrotic process enhancing collagen processing and deposition. PMID: 28059112
    2. This secreted cysteine protease potently converts membrane-bound meprin beta into its active form, impairing meprin beta shedding and its function as a mucus-detaching protease PMID: 29166602
    3. For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations. PMID: 28365001
    4. TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes PMID: 27180358
    5. n conclusion, we show that the concept of cleavable linkers specific for meprin beta is feasible, as the peptides are rapidly cleaved by the enzyme while retaining their biological properties PMID: 25855967
    6. Meprin Beta was found to be activated at the cell surface by matriptase-2. PMID: 26251449
    7. promotes inflammation in macrophages via ADAM-10 dependent pathway PMID: 24239627
    8. Overexpression of MEP1B is associated with pancreatic neuroendocrine tumors. PMID: 24114056
    9. Suggest role for in meprin-beta-Fra2 axis in mediating vascular remodelling in pulmonary hypertension. PMID: 24258247
    10. of the 151 new extracellular substrates identified, it was notable that ADAM10 the constitutive alpha-secretase-is activated by meprin beta through cleavage of the propeptide PMID: 22940918
    11. metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species PMID: 22879596
    12. Processing of APP by meprin beta was subsequently validated using in vitro and in vivo approaches. N-terminal APP fragments of about 11 and 20 kDa were found in human and mouse brain lysates but not in meprin beta(-/-) mouse brain lysates PMID: 21646356
    13. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains. PMID: 20953144
    14. data indicate that, at least under pathological conditions, meprinbeta might attack specific functional sites in tenascin-C that are important for its oligomerization and anti-adhesive activity PMID: 19748582
    15. results show that the O-linked carbohydrate side chains in hmeprinbeta are clustered around a 13 amino acid sequence that contains the main cleavage site for proteolytic processing of the subunit PMID: 12387727
    16. two different metalloprotease activities are responsible for the constitutive and the PMA-stimulated hmeprinbeta shedding PMID: 12941954

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Secreted.
  • 蛋白家族：
    Peptidase M12A family
  • 組織特異性：
    The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
  • 數據庫鏈接：

    HGNC: 7020

    OMIM: 600389

    KEGG: hsa:4225

    STRING: 9606.ENSP00000269202

    UniGene: Hs.194777



主站蜘蛛池模板： 思思99re6国产在线播放| 国产伦精品一区二区三区免费| 国产精品无码久久久久成人影院| 不卡无码av一区二区三区| 国产免费又色又爽又黄软件| 精品无码久久久久国产app| 久久久久99精品成人片三人毛片| 亚洲乱码精品久久久久..| 国内外精品激情刺激在线| 国内野外强奷在线视频| 久久99日韩国产精品久久99| 国产成人一区二区三区免费视频| 久久亚洲国产成人精品性色| 成年女人永久免费观看视频| 人妻无码一区二区三区 tv| 久久中文字幕乱码久久午夜| 精品国产电影久久九九| 国产又大又硬又粗| 2020久久香蕉国产线看观看| 国产精品国产三级国产av麻豆| 亚洲s久久久久一区二区| 免费欧洲美女牲交视频| 亚洲人成网站在线播放2019| 国产在线乱码一区二区三区| 97夜夜澡人人爽人人| 亚洲综合一区二区三区无码| 少妇被粗大的猛烈进出图片| 日韩美女自卫慰黄网站| 久久不见久久见www电影免费| 国产丝袜视频一区二区三区| 亚洲色偷偷色噜噜狠狠99网| 成人免费视频在线观看| 国产激情综合在线看| 国产成人精品av| 日韩精品久久无码中文字幕| 久久婷婷五月综合97色直播| 国产成人精品视觉盛宴| 无码精品黑人一区二区三区| 无码欧精品亚洲日韩一区| 麻豆国产成人av在线播放| 高清一区二区三区免费视频|