在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

MEP1B Antibody

  • 中文名稱:
    MEP1B兔多克隆抗體
  • 貨號(hào):
    CSB-PA618098ESR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: MEP1B antibody IgG at 2.36μg/ml + Mouse kidney tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 80 kDa
      Observed band size: 80 kDa
    • Immunohistochemistry of paraffin-embedded human small intestine tissue using CSB-PA618098ESR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) MEP1B Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    MEP1B
  • 別名:
    Endopeptidase 2 antibody; Endopeptidase-2 antibody; kinase splitting membranal proteinase antibody; KSMP antibody; Mep1b antibody; MEP1B_HUMAN antibody; Meprin 1 beta subunit antibody; Meprin A beta antibody; Meprin A beta subunit precursor antibody; Meprin A subunit beta antibody; Meprin B antibody; N benzoyl L tyrosyl P amino benzoic acid hydrolase beta subunit antibody; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit beta antibody; PABA peptide hydrolase antibody; PPH beta antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Meprin A subunit beta protein (480-652AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Membrane metallopeptidase that sheds many membrane-bound proteins. Exhibits a strong preference for acidic amino acids at the P1' position. Known substrates include: FGF19, VGFA, IL1B, IL18, procollagen I and III, E-cadherin, KLK7, gastrin, ADAM10, tenascin-C. The presence of several pro-inflammatory cytokine among substrates implicate MEP1B in inflammation. It is also involved in tissue remodeling due to its capability to degrade extracellular matrix components.
  • 基因功能參考文獻(xiàn):
    1. Results provide evidence that meprin beta is involved in collagen deposition in vivo in the lung of bleomycin treated mice and it localized in region with immature collagen. This suggests that meprin beta can favor the progression of the fibrotic process enhancing collagen processing and deposition. PMID: 28059112
    2. This secreted cysteine protease potently converts membrane-bound meprin beta into its active form, impairing meprin beta shedding and its function as a mucus-detaching protease PMID: 29166602
    3. For meprin beta a reduction and for BMP-1 an increase in activity was reported under increasing calcium concentrations. PMID: 28365001
    4. TSPAN8 might be important for the orchestration of meprin beta at the cell surface with impact on certain proteolytic processes PMID: 27180358
    5. n conclusion, we show that the concept of cleavable linkers specific for meprin beta is feasible, as the peptides are rapidly cleaved by the enzyme while retaining their biological properties PMID: 25855967
    6. Meprin Beta was found to be activated at the cell surface by matriptase-2. PMID: 26251449
    7. promotes inflammation in macrophages via ADAM-10 dependent pathway PMID: 24239627
    8. Overexpression of MEP1B is associated with pancreatic neuroendocrine tumors. PMID: 24114056
    9. Suggest role for in meprin-beta-Fra2 axis in mediating vascular remodelling in pulmonary hypertension. PMID: 24258247
    10. of the 151 new extracellular substrates identified, it was notable that ADAM10 the constitutive alpha-secretase-is activated by meprin beta through cleavage of the propeptide PMID: 22940918
    11. metalloprotease meprin beta generates amino terminal-truncated amyloid beta peptide species PMID: 22879596
    12. Processing of APP by meprin beta was subsequently validated using in vitro and in vivo approaches. N-terminal APP fragments of about 11 and 20 kDa were found in human and mouse brain lysates but not in meprin beta(-/-) mouse brain lysates PMID: 21646356
    13. Demonstrate that the metalloprotease meprin beta and gamma-ENaC associate directly through cytoplasmic domains. PMID: 20953144
    14. data indicate that, at least under pathological conditions, meprinbeta might attack specific functional sites in tenascin-C that are important for its oligomerization and anti-adhesive activity PMID: 19748582
    15. results show that the O-linked carbohydrate side chains in hmeprinbeta are clustered around a 13 amino acid sequence that contains the main cleavage site for proteolytic processing of the subunit PMID: 12387727
    16. two different metalloprotease activities are responsible for the constitutive and the PMA-stimulated hmeprinbeta shedding PMID: 12941954

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Single-pass type I membrane protein. Secreted.
  • 蛋白家族:
    Peptidase M12A family
  • 組織特異性:
    The major site of expression is the brush border membrane of small intestinal and kidney epithelial cells.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 7020

    OMIM: 600389

    KEGG: hsa:4225

    STRING: 9606.ENSP00000269202

    UniGene: Hs.194777



主站蜘蛛池模板: 亚洲一区二区三区高清在线看| 久久99久久99精品中文字幕| 扒开双腿吃奶呻吟做受视频| 国产h视频在线观看| 国产高清午夜人成在线观看| 国产亚洲精品电影网站在线观看| 亚洲老熟女av一区二区在线播放| 97久久精品亚洲中文字幕无码| 色综合视频一区二区三区| 久久亚洲美女精品国产精品 | 亚洲成av人综合在线观看| 欧美国产日韩a在线观看| 最近2019中文字幕在线| 大尺度无遮挡激烈床震网站| 国产成人无码一二三区视频| 女人和拘做爰正片视频| 亚洲精品一区二区不卡| av性色av久久无码ai换脸| 成人无码影片精品久久久| 国产免费一区二区视频| 日本熟妇人妻videos| 2020精品国产自在现线官网| 熟女人妻aⅴ一区二区三区60路| 国产一区二区精品久久| 国模国产精品嫩模大尺度视频| 在教室伦流澡到高潮h麻豆| 熟女视频一区二区在线观看| 日本熟妇人妻xxxxx| 亚洲综合精品第一页| 免费无码又爽又刺激激情视频软件| 国产精品无码久久av| 偷看农村妇女牲交| 粉嫩小泬视频无码视频软件| 欧美日韩精品一区二区三区高清视频| 国产丝袜美女一区二区三区| 婷婷五月婷婷五月| 日韩内射美女片在线观看网站| 一本大道东京热无码| 亚洲色成人网站www永久四虎 | 国产线观看免费观看| 亚洲蜜芽在线精品一区|