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  4. Recombinant Human Mediator of RNA polymerase II transcription subunit 19 (MED19)

Recombinant Human Mediator of RNA polymerase II transcription subunit 19 (MED19)

  • 中文名稱：
    人MED19重組蛋白
  • 貨號：
    CSB-YP013652HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MED19重組蛋白
  • 貨號：
    CSB-EP013652HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MED19重組蛋白
  • 貨號：
    CSB-EP013652HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MED19重組蛋白
  • 貨號：
    CSB-BP013652HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MED19重組蛋白
  • 貨號：
    CSB-MP013652HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MED19
  • Uniprot No.：
  • 別名：
    LCMR1; Lung cancer metastasis related protein 1; Lung cancer metastasis-related protein 1; med19; MED19_HUMAN; Mediator complex subunit 19; Mediator of RNA polymerase II transcription subunit 19
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full length protein
  • 表達區(qū)域：
    1-244
  • 氨基酸序列
    MENFTALFGA QADPPPPPTA LGFGPGKPPP PPPPPAGGGP GTAPPPTAAT APPGADKSGA GCGPFYLMRE LPGSTELTGS TNLITHYNLE QAYNKFCGKK VKEKLSNFLP DLPGMIDLPG SHDNSSLRSL IEKPPILSSS FNPITGTMLA GFRLHTGPLP EQCRLMHIQP PKKKNKHKHK QSRTQDPVPP ETPSDSDHKK KKKKKEEDPD RKRKKKEKKK KKNRHSPDHP GMGSSQASSS SSLR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
  • 基因功能參考文獻：
    1. The data suggest that Med19 expression correlates with aggressive characteristics of bladder cancer, and Med19 knockdown suppresses the proliferation and migration of cancer cells through down-regulating the Wnt/beta-catenin pathway. PMID: 28631286
    2. DEK and LCMR1 were demonstrated to cooperate in the inhibition of apoptosis in lung cancer cells. PMID: 28765911
    3. LCMR1 modulation was sufficient to positively regulate endogenous Tspan8 expression, with concomitant in vitro phenotypic changes such as loss of melanoma cell-matrix adherence and increase in invasion, and Tspan8 expression promoted tumourigenicity in vivo. PMID: 27375018
    4. We knocked down the Med19 expression in prostate cancer cell lines LNCaP and PC3 by using lentivirus siRNA. Cell proliferation, anchor-independent growth, migration, and invasion were suppressed in Med19 knockdown prostate cancer cells. PMID: 28125713
    5. Med19 promotes breast cancer cell proliferation and that this effect is associated with regulating CBFA2T3 and HEB expression. PMID: 27572702
    6. FOXD3/miR-214/MED19 axis is important for the regulation of growth, invasion and metastasis of colorectal cancer PMID: 27811858
    7. High expression of Med19 is associated with cisplatin resistance in non-small cell lung cancer cells. PMID: 25735376
    8. Data show that the expression of Mediator of RNA polymerase II transcription subunit 19 (Med19) was increased in Osteosarcoma (OS) samples from patients compared to normal bone tissues. PMID: 24565852
    9. High Med19 expression is associated with tongue cancer. PMID: 23705783
    10. Med19 promotes bone metastasis and invasiveness of bladder urothelial carcinoma via bone morphogenetic protein 2. PMID: 23276457
    11. Med19 is markedly up-regulated in bladder cancer tissues PMID: 21478038
    12. LCMR1 suppresses apoptosis in lung cancer cells and this effect is associated with multiple apoptosis-related proteins, including p53, Bax and Mcl-1. PMID: 23076562
    13. High MED19 expression is associated with lung adenocarcinoma cell clone conformation, growth, and metastasis. PMID: 23098456
    14. Med19 functions in promoting cellular growth and may be a useful therapeutic target in malignant gastric carcinoma PMID: 22565189
    15. The effect of downregulation of LCMR1 by lentivirus-mediated small hairpin RNA (shRNA) on colorectal cancer cell proliferation and tumorigenesis was explored. PMID: 21732059
    16. MED19 serves as a novel proliferation regulator that promotes growth of prostate cancer cells. PMID: 21871180
    17. MED19 is a novel proliferation regulator that promotes growth of lung cancer cells PMID: 21519921
    18. results provide new evidence of an important role for Med19 in the development of hepatocellular carcinomas PMID: 21372827
    19. upregulated expression of Med19 was found in breast cancer tissues; Med19 expression was significantly associated with tumor grade PMID: 20890603
    20. LCMR1 was strongly overexpressed in NSCLC and its expression was significantly associated with clinical stage. PMID: 21306606
    21. MED19 played an important role in cell growth and cell cycle progression of human osteosarcoma cells. PMID: 21542455
    22. findings identify MED19/MED26 as a probable composite REST interface in Mediator and further clarify the mechanistic basis by which Mediator facilitates REST-imposed epigenetic restrictions on neuronal gene expression PMID: 19049968

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Mediator complex subunit 19 family
  • 數據庫鏈接：

    HGNC: 29600

    OMIM: 612385

    KEGG: hsa:219541

    STRING: 9606.ENSP00000337340

    UniGene: Hs.43619



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