在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Major centromere autoantigen B (CENPB)

Recombinant Human Major centromere autoantigen B (CENPB)

  • 中文名稱：
    Recombinant Human Major centromere autoantigen B(CENPB)
  • 貨號：
    CSB-YP005206HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Major centromere autoantigen B(CENPB)
  • 貨號：
    CSB-EP005206HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Major centromere autoantigen B(CENPB)
  • 貨號：
    CSB-BP005206HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Major centromere autoantigen B(CENPB)
  • 貨號：
    CSB-MP005206HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    CENP B; CENP-B; CENPB; CENPB_HUMAN; centromere autoantigen B; Centromere protein B; Centromere protein B; 80kDa; Major centromere autoantigen B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-599
  • 氨基酸序列
    GPKRRQLTF REKSRIIQEV EENPDLRKGE IARRFNIPPS TLSTILKNKR AILASERKYG VASTCRKTNK LSPYDKLEGL LIAWFQQIRA AGLPVKGIIL KEKALRIAEE LGMDDFTASN GWLDRFRRRH GVVSCSGVAR ARARNAAPRT PAAPASPAAV PSEGSGGSTT GWRAREEQPP SVAEGYASQD VFSATETSLW YDFLPDQAAG LCGGDGRPRQ ATQRLSVLLC ANADGSEKLP PLVAGKSAKP RAGQAGLPCD YTANSKGGVT TQALAKYLKA LDTRMAAESR RVLLLAGRLA AQSLDTSGLR HVQLAFFPPG TVHPLERGVV QQVKGHYRQA MLLKAMAALE GQDPSGLQLG LTEALHFVAA AWQAVEPSDI AACFREAGFG GGPNATITTS LKSEGEEEEE EEEEEEEEEG EGEEEEEEGE EEEEEGGEGE ELGEEEEVEE EGDVDSDEEE EEDEESSSEG LEAEDWAQGV VEAGGSFGAY GAQEEAQCPT LHFLEGGEDS DSDSEEEDDE EEDDEDEDDD DDEEDGDEVP VPSFGEAMAY FAMVKRYLTS FPIDDRVQSH ILHLEHDLVH VTRKNHARQA GVRGLGHQS
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Interacts with centromeric heterochromatin in chromosomes and binds to a specific 17 bp subset of alphoid satellite DNA, called the CENP-B box. May organize arrays of centromere satellite DNA into a higher-order structure which then directs centromere formation and kinetochore assembly in mammalian chromosomes (Probable).
  • 基因功能參考文獻：
    1. Given that CENP-B is the only centromere protein that binds centromere-specific DNA elements, our study provides a new link between centromere DNA and unique epigenetic landscape of centromere chromatin PMID: 29273057
    2. The results indicated that CENPB boxes are highly conserved in Down syndrome (DS) patients and may not be responsible for Chr21 nondisjunction events. However, alphasatDNA in Chr21 is variable and deoxynucleotide deletions, mutations and polymorphisms may act as potential molecular diagnostic markers of DS. PMID: 28259924
    3. The results revealed that CENP-B binding in the vicinity of the CENP-A nucleosome substantially stabilizes the CENP-A nucleosome on alphoid DNA in human cells. PMID: 25916850
    4. Centromere protein B (CENP-B) as a novel interacting partner of HBZ. PMID: 25281565
    5. INMAP as a model regulator of CENP-B PMID: 24633075
    6. N-terminal methylation is required for CENP-B's binding to the CENP-B box. PMID: 23978223
    7. Human Nap1, an acidic histone chaperone, inhibited the non-specific binding of CENP-B to nucleosomes and apparently stimulated CENP-B binding to its cognate CENP-B box DNA. PMID: 23325853
    8. Anti-CENP-B autoantibodies in breast cancer patients prolong disease-free and overall survival. PMID: 20222802
    9. crystal structure of its dimerization domain (CENP-B-(540-599)), another functional domain of CENP-B, at 1.65-A resolution PMID: 14522975
    10. the interaction between CENP-B and CENP-C may be involved in the correct assembly of CENP-C on alphoid DNA PMID: 14612452
    11. CENP-B for the CENP-B box DNA is reduced nearly to the level of nonspecific DNA binding by CpG methylation PMID: 15634350
    12. CENP-B may be a determinant for translational positioning of the centromere-specific nucleosomes through its binding to the nucleosomal CENP-B box PMID: 16183641
    13. This study shows that ICP0 induces the proteasomal-dependent degradation of the centromeric protein CENP-B in infected as well as ICP0-expressing cells. PMID: 17258208
    14. CENP-B was found to bind specifically to the surface of human pulmonary artery smooth muscle cells and not to fibroblasts or endothelial cells PMID: 17968937
    15. observation of FRET between CENP-A and CENP-B at centromere locations; this indicates that these proteins are in the molecular vicinity (<10 nm) of each other PMID: 18072184
    16. CENP-B binding stimulated the cross-talk between CCR3 and epidermal growth factor receptor (EGFR) in human pulmonary artery smooth muscle cells. PMID: 19714638
    17. Study analyzed the distribution of PARP-1 and its interaction with CENP-B, -E, and -F during mitosis and apoptosis. PMID: 19723035

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Chromosome, centromere.
  • 數據庫鏈接：

    HGNC: 1852

    OMIM: 117140

    KEGG: hsa:1059

    STRING: 9606.ENSP00000369075

    UniGene: Hs.516855



主站蜘蛛池模板： 2020无码专区人妻系列日韩| 国产精品亚亚洲欧关中字幕| 两个黑人大战嫩白金发美女| 欧美熟妇另类久久久久久多毛| 国产色欲色欱www在线| 日韩人妻不卡一区二区三区| 波多野结衣办公室33分钟| 亚洲日韩中文字幕一区| 亚洲中文无码人a∨在线导航| 日本丰满护士爆乳xxxx| 国产人妻一区二区三区四区五区六| 亚洲 成人 无码 在线观看| 色综合天天视频在线观看| 国产成人a∨麻豆精品| 中文无码天天av天天爽| 成人h视频在线观看| 乱人伦无码中文视频在线| 欧美日韩无砖专区一中文字| 亚洲精品无码国产片| 免费无码av一区二区| 日本国产成人国产在线播放| 亚洲人成网站18禁止一区| 亚洲www啪成人一区二区麻豆| 中文字幕av伊人av无码av| 亚洲欧美不卡高清在线观看| 久久久久久久99精品免费观看| 无码一区二区三区av免费| 熟妇玩小男视频在线| 国内精品久久人妻互换| 久久天天躁狠狠躁夜夜网站| 青草伊人久久综在合线亚洲观看 | 99riav国产精品视频| 女学生14毛片视频片二毛 | 日韩精品一区二区午夜成人版| 麻批好紧日起要舒服死了| 永久久久免费人妻精品| av片在线播放| 荡女精品导航| 亚洲欧美成人综合图区| 无码精品黑人一区二区三区| 国产成人一区二区三区别 |