在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Lysine-specific demethylase PHF2 (PHF2), partial

  • 中文名稱:
    人PHF2重組蛋白
  • 貨號:
    CSB-YP017908HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人PHF2重組蛋白
  • 貨號:
    CSB-EP017908HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人PHF2重組蛋白
  • 貨號:
    CSB-EP017908HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人PHF2重組蛋白
  • 貨號:
    CSB-BP017908HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人PHF2重組蛋白
  • 貨號:
    CSB-MP017908HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    PHF2
  • Uniprot No.:
  • 別名:
    CENP-35; GRC5; JHDM1E; Jumonji C domain containing histone demethylase 1E ; Lysine-specific demethylase PHF2; PHD finger protein 2; Phf2; PHF2_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lysine demethylase that demethylates both histones and non-histone proteins. Enzymatically inactive by itself, and becomes active following phosphorylation by PKA: forms a complex with ARID5B and mediates demethylation of methylated ARID5B. Demethylation of ARID5B leads to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver. PHF2 is recruited to trimethylated 'Lys-4' of histone H3 (H3K4me3) at rDNA promoters and promotes expression of rDNA. Involved in the activation of toll-like receptor 4 (TLR4)-target inflammatory genes in macrophages by catalyzing the demethylation of trimethylated histone H4 lysine 20 (H4K20me3) at the gene promoters.
  • 基因功能參考文獻:
    1. Our results demonstrate that the IKAROS promotes PHF2 expression, and suggest that PHF2 (low) expression works with the IKAROS gene deletion to drive oncogenesis of ALL PMID: 28994305
    2. Frameshift mutations of PHF2 may play a role in tumorigenesis through its TSG inactivation in CRC and GC. PMID: 27744626
    3. PHF2 acts as a tumor suppressor in association with p53 in cancer development and ensures p53-mediated cell death in response to chemotherapy. PMID: 25043306
    4. PHF2 is likely to repress rDNA transcription by competing with PHF8 for binding of ribosomal DNA promoter and by recruiting H3K9me2/3 methyltransferase SUV39H1. PMID: 25204660
    5. JARID1B and PHF2 are overexpressed in esophageal squamous cell carcinoma (ESCC) and they may play crucial roles in the course of ESCC initiation and/or progression PMID: 22534467
    6. the crystal structures of PHF2 Jumonji domain in the absence and presence of additional exogenous metal ions were determined. PMID: 21167174
    7. Differential association of alterations in FANCC and PTCH1 with that of PHF2, XPA and two breast cancer susceptibility genes (BRCA1/BRCA2) in the two age groups suggests differences in their molecular pathogenesis. PMID: 18990233

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus, nucleolus. Chromosome, centromere, kinetochore.
  • 蛋白家族:
    JHDM1 histone demethylase family, JHDM1D subfamily
  • 組織特異性:
    Widely expressed, including in liver (at protein level).
  • 數據庫鏈接:

    HGNC: 8920

    OMIM: 604351

    KEGG: hsa:5253

    STRING: 9606.ENSP00000352185

    UniGene: Hs.211441



主站蜘蛛池模板: 亚洲伊人久久大香线蕉综合图片| 精品aⅴ一区二区三区| 精品久久久久久国产| 色欲网天天无码av| 日本高清在线www3344| 久久精品农村毛片| 奇米影视777四色米奇影院| 1000部拍拍拍18勿入免费视频| av激情亚洲男人的天堂| 男女真人国产牲交a做片野外| 天天综合网网欲色| 天堂无码人妻精品一区二区三区| 国产午夜无码片在线观看网站| 高潮喷吹一区二区在线观看| 成人内射国产免费观看| 自拍偷自拍亚洲精品被多人伦好爽| 人妻插b视频一区二区三区| 欧美性xxxx极品hd欧美风情| 久久精品国产99国产精2020丨| 97人妻人人揉人人躁人人| 影音先锋亚洲成aⅴ人在| 少妇午夜av一区| 久久久99无码一区| 亚洲欧美国产双大乳头| 久久国产劲暴∨内射新川| 人妻中文无码久热丝袜| 人妻熟女一区二区aⅴ千叶宁真 | 亚洲精品无码av中文字幕| 让少妇高潮无乱码高清在线观看| 丝袜无码一区二区三区| 韩产日产国产欧产| 妺妺窝人体色www在线下载| 秋霞av鲁丝片一区二区| 亚洲色欲色欲综合网站| 亚洲一区二区三区无码av| 亚洲另类欧美小说图片区 | 国产边摸边吃奶边做爽视频| 亚洲的天堂av无码| 国产精品自在欧美一区| 中文字幕精品亚洲无线码二区| 日日夜夜撸啊撸|