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  4. Recombinant Human Lysine-specific demethylase 4C (KDM4C), partial

Recombinant Human Lysine-specific demethylase 4C (KDM4C), partial

  • 中文名稱：
    人KDM4C重組蛋白
  • 貨號：
    CSB-YP872489HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人KDM4C重組蛋白
  • 貨號：
    CSB-EP872489HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人KDM4C重組蛋白
  • 貨號：
    CSB-EP872489HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人KDM4C重組蛋白
  • 貨號：
    CSB-BP872489HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人KDM4C重組蛋白
  • 貨號：
    CSB-MP872489HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    KDM4C
  • Uniprot No.：
  • 別名：
    bA146B14.1; GASC 1 protein; GASC-1 protein; GASC1; Gene amplified in squamous cell carcinoma 1 protein; JHDM3C; JmjC domain containing histone demethylation protein 3C; JmjC domain-containing histone demethylation protein 3C; JMJD2C; Jumonji domain containing 2C; Jumonji domain containing protein 2C; Jumonji domain-containing protein 2C; Kdm4c; KDM4C_HUMAN; Lysine (K) specific demethylase 4C; Lysine demethylase 4C; Lysine-specific demethylase 4C; TDRD14C; Tudor domain containing 14C
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能參考文獻：
    1. JMJD2C regulated the activities of lung cancer cells by directly controlling the expression of CUL4A in JMJD2C over-expression cell line. PMID: 28236704
    2. histone H3 lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C, was found in CD4(+) T lymphocytes of Latent autoimmune diabetes in adult patients PMID: 28396876
    3. KDM4C recognition of H3K4me3 stimulates demethylation of H3K9me3 in cis on peptide and mononucleosome substrates. PMID: 26747609
    4. Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions PMID: 26766589
    5. Data suggest that D396N polymorphism of JmjC domain-containing histone demethylase JMJD2C affects the prognosis of breast cancer by altering caspase-3 cleavage and the ability of double strand DNA break repair which may contribute to therapy resistance. PMID: 24952432
    6. GASC1 expression is higher in adenocarcinoma than squamous cell carcinoma. Smoking decreases GASC1 expression in tumor cells, indicating that tobacco smoke may influence the methylation of histone 3 lysine residues in lung cancer. PMID: 24371038
    7. KDM4C promotes transcriptional activation by removing the repressive histone mark, H3K9me3, from its target genes. Variation in its expression leads to differences in the growth of normal and some cancer cells. PMID: 24285722
    8. KDM4C maintains the sphere-forming capacity in CRCs by mediating the beta-catenin-dependent transcription of JAG1 in a feed-forward manner. PMID: 23698634
    9. analysis of the nickel-induced inhibition of truncated constructs of JMJD2A and JMJD2C histone demethylases using X-ray absorption spectroscopy PMID: 23692052
    10. Patients with GASC1 positive tumors have better breast cancer specific survival and respond better to radiotherapy and hormonal treatment PMID: 23148692
    11. JMJD2C decreases trimethylation of histone H3 at lysine 9, and enhances HIF-1 binding to hypoxia response elements, thereby activating transcription of proteins that are required for metabolic reprogramming and for lung metastasis. PMID: 23129632
    12. JMJD2C displays an optimal activity in vitro at alphaKG concentrations similar to those found in cancer cells, with implications for the regulation of histone demethylation activity in cancer versus normal cells. PMID: 23067339
    13. This study presented that KDM4C showed strong associations with alcohol withdrawal symptoms (p < 5 x 10-5). PMID: 22072270
    14. inhibition measurements showed significant selectivity between KDM4C and KDM6A PMID: 21575637
    15. The strongest association in obsessive-compulsive disorder has been found at rs301443 (P=0.000067) residing between SLC1A1 and JMJD2C at 9p24. PMID: 20410850
    16. GASC1 interacts with H3K9me3; three members of this subfamily of proteins demethylate H3K9me3/me2 in vitro through a hydroxylation reaction requiring iron and alpha-ketoglutarate as cofactors PMID: 16732293
    17. JMJD2C is the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. PMID: 17611647
    18. Gene rearrangements of JMJD2C is associated with mucosa-associated lymphoid tissue lymphoma. PMID: 18927281
    19. GASC1 is a driving oncogene in the 9p23-24 amplicon in human breast cancer. PMID: 19784073

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    JHDM3 histone demethylase family
  • 組織特異性：
    Overexpressed in several esophageal squamous cell carcinomas (ESCs).
  • 數據庫鏈接：

    HGNC: 17071

    OMIM: 605469

    KEGG: hsa:23081

    STRING: 9606.ENSP00000370710

    UniGene: Hs.709425



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