在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

KDM4C Antibody

  • 中文名稱:
    KDM4C兔多克隆抗體
  • 貨號:
    CSB-PA872489HA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human endometrial cancer using CSB-PA872489HA01HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA872489HA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) KDM4C Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    KDM4C
  • 別名:
    bA146B14.1 antibody; GASC 1 protein antibody; GASC-1 protein antibody; GASC1 antibody; Gene amplified in squamous cell carcinoma 1 protein antibody; JHDM3C antibody; JmjC domain containing histone demethylation protein 3C antibody; JmjC domain-containing histone demethylation protein 3C antibody; JMJD2C antibody; Jumonji domain containing 2C antibody; Jumonji domain containing protein 2C antibody; Jumonji domain-containing protein 2C antibody; Kdm4c antibody; KDM4C_HUMAN antibody; Lysine (K) specific demethylase 4C antibody; Lysine demethylase 4C antibody; Lysine-specific demethylase 4C antibody; TDRD14C antibody; Tudor domain containing 14C antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Lysine-specific demethylase 4C protein (450-600AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,KDM4C Antibody (CSB-PA872489HA01HU),的標記方式是Non-conjugated。對于KDM4C Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA872489HB01HU KDM4C Antibody, HRP conjugated ELISA
    FITC CSB-PA872489HC01HU KDM4C Antibody, FITC conjugated
    Biotin CSB-PA872489HD01HU KDM4C Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.
  • 基因功能參考文獻:
    1. JMJD2C regulated the activities of lung cancer cells by directly controlling the expression of CUL4A in JMJD2C over-expression cell line. PMID: 28236704
    2. histone H3 lysine 9 methylation reduction, which may be due to the downregulation of methyltransferase SUV39H2 and the upregulation of demethylase KDM4C, was found in CD4(+) T lymphocytes of Latent autoimmune diabetes in adult patients PMID: 28396876
    3. KDM4C recognition of H3K4me3 stimulates demethylation of H3K9me3 in cis on peptide and mononucleosome substrates. PMID: 26747609
    4. Pharmacological inhibition of KDM4C/PRMT1 suppresses transcription and transformation ability of MLL fusions PMID: 26766589
    5. Data suggest that D396N polymorphism of JmjC domain-containing histone demethylase JMJD2C affects the prognosis of breast cancer by altering caspase-3 cleavage and the ability of double strand DNA break repair which may contribute to therapy resistance. PMID: 24952432
    6. GASC1 expression is higher in adenocarcinoma than squamous cell carcinoma. Smoking decreases GASC1 expression in tumor cells, indicating that tobacco smoke may influence the methylation of histone 3 lysine residues in lung cancer. PMID: 24371038
    7. KDM4C promotes transcriptional activation by removing the repressive histone mark, H3K9me3, from its target genes. Variation in its expression leads to differences in the growth of normal and some cancer cells. PMID: 24285722
    8. KDM4C maintains the sphere-forming capacity in CRCs by mediating the beta-catenin-dependent transcription of JAG1 in a feed-forward manner. PMID: 23698634
    9. analysis of the nickel-induced inhibition of truncated constructs of JMJD2A and JMJD2C histone demethylases using X-ray absorption spectroscopy PMID: 23692052
    10. Patients with GASC1 positive tumors have better breast cancer specific survival and respond better to radiotherapy and hormonal treatment PMID: 23148692
    11. JMJD2C decreases trimethylation of histone H3 at lysine 9, and enhances HIF-1 binding to hypoxia response elements, thereby activating transcription of proteins that are required for metabolic reprogramming and for lung metastasis. PMID: 23129632
    12. JMJD2C displays an optimal activity in vitro at alphaKG concentrations similar to those found in cancer cells, with implications for the regulation of histone demethylation activity in cancer versus normal cells. PMID: 23067339
    13. This study presented that KDM4C showed strong associations with alcohol withdrawal symptoms (p < 5 x 10-5). PMID: 22072270
    14. inhibition measurements showed significant selectivity between KDM4C and KDM6A PMID: 21575637
    15. The strongest association in obsessive-compulsive disorder has been found at rs301443 (P=0.000067) residing between SLC1A1 and JMJD2C at 9p24. PMID: 20410850
    16. GASC1 interacts with H3K9me3; three members of this subfamily of proteins demethylate H3K9me3/me2 in vitro through a hydroxylation reaction requiring iron and alpha-ketoglutarate as cofactors PMID: 16732293
    17. JMJD2C is the histone demethylase implicated in the epigenetic reprogramming during the early embryogenesis. PMID: 17611647
    18. Gene rearrangements of JMJD2C is associated with mucosa-associated lymphoid tissue lymphoma. PMID: 18927281
    19. GASC1 is a driving oncogene in the 9p23-24 amplicon in human breast cancer. PMID: 19784073

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    JHDM3 histone demethylase family
  • 組織特異性:
    Overexpressed in several esophageal squamous cell carcinomas (ESCs).
  • 數據庫鏈接:

    HGNC: 17071

    OMIM: 605469

    KEGG: hsa:23081

    STRING: 9606.ENSP00000370710

    UniGene: Hs.709425



主站蜘蛛池模板: 巨胸爆乳美女露双奶头挤奶| 亚洲人妻av伦理| 高潮毛片无遮挡高清免费| 久久99国产综合精品免费| 国产95在线 | 欧美| 蜜臀av综合网| 77777五月色婷婷丁香视频| 又黄又湿免费高清视频| 噜噜久久噜噜久久鬼88| 日本人妻巨大乳挤奶水| 朝鲜女人大白屁股ass| 国产极品精品自在线| 午夜福利18以下勿进免费| 亚洲欧洲久久av| 国产乱子伦精品无码码专区 | 无码熟妇人妻av在线影片免费| 在线成 人av影院| 极品老师腿张开粉嫩小泬| 久久久久黑人强伦姧人妻| 女人被狂躁到高潮视频免费软件| 曰本无码不卡高清av一二| 久久精品人人槡人妻人人玩av | 国产精品亚洲玖玖玖在线观看| 亚洲欧美第一成人网站7777| 性史性农村dvd毛片| 中文字幕丰满孑伦无码精品| 一卡二卡3卡4卡视频免费播放 | 成人精品一区二区三区电影| 夜夜爽夜夜叫夜夜高潮漏水| 青青青青国产免费线在线观看| 亚洲精品综合欧美一区二区| 疯狂三人交性欧美| 久久久久久自慰出白浆| 亚洲无线观看国产精品| 西西人体大胆扒开下部337卩| 亚洲成av人片在线观看高清| 欧美浓毛大泬视频| 久久久精品人妻久久影视| 国产成人欧美亚洲日韩电影| 俄罗斯少妇性xxxx另类| 无码人妻精品一区二区三区蜜桃|