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  4. Recombinant Human Liprin-alpha-1 (PPFIA1), partial

Recombinant Human Liprin-alpha-1 (PPFIA1), partial

  • 中文名稱：
    人PPFIA1重組蛋白
  • 貨號：
    CSB-YP618760HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人PPFIA1重組蛋白
  • 貨號：
    CSB-EP618760HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人PPFIA1重組蛋白
  • 貨號：
    CSB-EP618760HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人PPFIA1重組蛋白
  • 貨號：
    CSB-BP618760HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人PPFIA1重組蛋白
  • 貨號：
    CSB-MP618760HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    PPFIA1
  • Uniprot No.：
  • 別名：
    FLJ42630; HGNC:9245; LAR interacting protein 1; LAR-interacting protein 1; LIP 1; LIP-1; LIP.1; LIP1; LIPA1_HUMAN; Liprin alpha 1; LIPRIN; Liprin-alpha-1; MGC26800; PPFIA 1; PPFIA1; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 1; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 1; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-1; PTPRF interacting protein alpha 1; PTPRF-interacting protein alpha-1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
  • 基因功能參考文獻：
    1. The results indicate that liprin-alpha1, LL5 and ERC1 define a novel dynamic membrane-less compartment that regulates matrix degradation by affecting invadosome motility. PMID: 29348417
    2. This study shows that PPFIA1 is required for FN polymerization-dependent vascular morphogenesis, both in vitro and in the developing zebrafish embryo. PMID: 27876801
    3. Based on these findings, we infer that high PPFIA1 expression might be an independent prognostic indicator of increased metastatic relapse risk in patients with estrogen receptor+/N- breast cancer, but not in estrogen receptor+/N+ or estrogen receptor- patients. PMID: 28720060
    4. The human tumor cell line MDA-MB-231 expresses liprin-alpha 1 and is able to promote the formation of metastasis in mice. PMID: 26663347
    5. results suggested that PPFIA1 functioned with PP2A to promote the dephosphorylation of Kif7, triggering Kif7 localization to the tips of primary cilia and promoting Gli transcriptional activity. PMID: 25492966
    6. Liprin-alpha1, ERC1a and LL5 also define new highly polarized and dynamic cytoplasmic structures uniquely localized near the protruding cell edge PMID: 24982445
    7. PPFIA1 was frequently co-amplified with the Cyclin D1 gene in oral carcinomas and could present a biomarker as well as a novel target for specific gene therapy. PMID: 23453270
    8. PPFIA1 as a potential functional candidate acute lung injury risk gene PMID: 22295056
    9. The results of this study finding suggested that a model by which the self-assembly of SYD-2/Liprin-alpha proteins mediated by the coiled-coil LH1 domain is one of the key steps to the accumulation of presynaptic components at nascent synaptic junctions PMID: 22072677
    10. These results suggest that an increased expression of Liprin-alpha1 in the brain may be associated with human Intractable epilepsy . PMID: 21157931
    11. Data show that increased levels of liprin-alpha1 affected the localization of inactive, low-affinity integrins, while increasing the average size of beta1 integrin-positive focal adhesions. PMID: 20096687
    12. Amplification of both PPFIA1 and CCND1 were significantly associated with high-grade breast cancer phenotype but were unrelated to tumor stage or nodal stage PMID: 19787783
    13. the interaction between ERC2 and liprin-alpha may be involved in the presynaptic localization of liprin-alpha and the molecular organization of presynaptic active zones PMID: 12923177
    14. liprin binds to ATP-agarose, challenged by free ATP, not by free GTP. Liprin LH region mutations inhibit liprin phosphorylation stabilized association of liprin with ATP-agarose. Suggests that liprin autophosphorylation regulates its association with LAR. PMID: 16313174
    15. regulated degradation of liprinalpha1 is important for proper LAR receptor distribution, and could provide a mechanism for localized control of dendrite and synapse morphogenesis by activity and CaMKII. PMID: 17419996
    16. Amplification and overexpression of PPFIA1, a putative 11q13 invasion suppressor gene, is associated with head and neck squamous cell carcinoma PMID: 18196592
    17. Liprin is an essential regulator of cell motility that contributes to the effectiveness of cell-edge protrusion. PMID: 19690048

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  • 亞細胞定位：
    Cytoplasm. Note=Colocalizes with PTPRF at the ends of focal adhesions most proximal to the cell nucleus.
  • 蛋白家族：
    Liprin family, Liprin-alpha subfamily
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 9245

    OMIM: 611054

    KEGG: hsa:8500

    STRING: 9606.ENSP00000253925

    UniGene: Hs.530749



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