在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Lecithin retinol acyltransferase (LRAT), partial

Recombinant Human Lecithin retinol acyltransferase (LRAT), partial

  • 中文名稱：
    人LRAT重組蛋白
  • 貨號：
    CSB-YP013069HU1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LRAT重組蛋白
  • 貨號：
    CSB-EP013069HU1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LRAT重組蛋白
  • 貨號：
    CSB-EP013069HU1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LRAT重組蛋白
  • 貨號：
    CSB-BP013069HU1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LRAT重組蛋白
  • 貨號：
    CSB-MP013069HU1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    LRAT
  • Uniprot No.：
  • 別名：
    LRAT; Lecithin retinol acyltransferase; Phosphatidylcholine--retinol O-acyltransferase
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology.
  • 基因功能參考文獻：
    1. The genetic analysis performed on our proband showed a novel homozygous mutation on codon 119 of lecithin-cholesterol acyltransferase gene that causes the substitution of glycine by aspartate PMID: 28942093
    2. instability of LRAT(E14L) did not abrogate the production of the visual chromophore in a cell-based assay. Instead, expression of LRAT(E14L) led to a rapid increase in cellular levels of retinoic acid upon retinoid supplementation. PMID: 28758396
    3. LRAT hypermethylation was associated with decreased mRNA levels in colorectal cancer clinical specimens. PMID: 25260806
    4. lecithin retinol acyltransferase affects all-trans retinoic acid levels and has a role in retinoid sensitivity in malignant melanoma cells. PMID: 25236354
    5. These findings reveal structural adaptation that facilitates selective catalysis and mechanism responsible for diverse substrate specificity within the LRAT-like enzyme family PMID: 25383759
    6. high LRAT expression in melanoma might be important in removing retinol as substrate for RA production, thereby inducing signalling pathways leading to dedifferentiation, proliferation and anti-apoptosis PMID: 24433184
    7. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1, that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis. PMID: 23890161
    8. Lecithin-retinol acyltransferase is a thermostable and highly active enzyme with a likely mode of interfacial activation. PMID: 24613493
    9. A genetic defect was identified in LRAT as a novel cause of retinitis punctata albescens. PMID: 22559933
    10. Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT. PMID: 22605381
    11. LRAT mutations cause a severe, early childhood onset, progressive retinal dystrophy. PMID: 22570351
    12. This study showed that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions. PMID: 21465477
    13. Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis. PMID: 19471114
    14. LRAT expression is higher in renal tumors with an indolent biological behavior PMID: 14581364
    15. Conserved residues Cys-161 and His-60 form the essential catalytic dyad of LRAT that represents a novel thiol protease motif, which functions in an acyltransferase reaction. PMID: 14596594
    16. LRAT has a role in preventing progression of invasive bladder cancer PMID: 15161698
    17. Results provide evidence that multiple LRAT mRNA transcripts, which are expressed in a tissue-specific manner, may result from differential splicing of the 5'UTR region and the use of multiple polyadenylation signals in the 3'UTR. PMID: 15474300
    18. LRAT has a role in retinoid absorption and storage PMID: 16115871
    19. These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase. PMID: 16939223
    20. The phenotype of patients with mutations in LRAT is similar to that of patients with mutations in RPE65, suggesting the need to systematically screen both genes in case of typical phenotype. PMID: 17011878
    21. LRAT mutations are likely a rare cause of Leber congenital amaurosis among patients from North America. PMID: 17438524
    22. Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver. PMID: 18544127
    23. transcriptional regulation is aberrant in human prostate cancer and involves GATA transcription factors in normal prostate epithelial cells PMID: 18652909
    24. proximal region together with basal transcription factors may be sufficient to drive Lrat expression. PMID: 19665987

    顯示更多

    收起更多

  • 相關疾病：
    Leber congenital amaurosis 14 (LCA14)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum. Endosome, multivesicular body. Cytoplasm, perinuclear region.
  • 蛋白家族：
    H-rev107 family
  • 組織特異性：
    Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed
  • 數據庫鏈接：

    HGNC: 6685

    OMIM: 604863

    KEGG: hsa:9227

    STRING: 9606.ENSP00000337224

    UniGene: Hs.658427



主站蜘蛛池模板： 国产亚洲精品成人aa片新蒲金| 无套内谢少妇毛片aaaa片免费| 国产精品青青青高清在线| 女厕厕露p撒尿八个少妇| 国产又色又爽又黄刺激在线视频| 国产精品人人妻人人爽| 亚洲a综合一区二区三区| 亚洲精品久久久久一区二区三区| 蜜臀av夜夜澡人人爽人人| 亚洲s码欧洲m码国产av| av色国产色拍| 亚洲丰满熟妇在线播放电影全集 | 成人性生交大片免费看中文| 国产爆乳无码视频在线观看3| 亚洲第一狼人天堂久久| av天堂午夜精品蜜臀av| 色77久久综合网| 少妇做爰免费视看片| 97久久国产露脸精品国产| 国产乱人伦av在线a最新| 上司人妻互换中文字幕| 免费观看18禁无遮挡真人网站| 中文字幕无码人妻丝袜| 久久人搡人人玩人妻精品 | 在线视频免费观看爽爽爽| 忘忧草日本在线www| 日韩精品无码免费一区二区三区 | 九九热线精品视频16| 国产真实乱对白精彩久久| 国产丝袜美女一区二区三区| √8天堂资源地址中文在线| 一区一区三区产品乱码亚洲| 天堂а在线中文在线新版| 国产97色在线 | 国产| 亚洲国产欧美不卡在线观看| 日韩精品无码熟人妻视频| 国产亚洲精品a在线无码| 无码av动漫精品一区二区免费| 无码骚夜夜精品| 少妇性饥渴无码a区免费| 亚洲午夜久久久久妓女影院|