在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

LRAT Antibody, HRP conjugated

  • 中文名稱:
    LRAT兔多克隆抗體, HRP偶聯
  • 貨號:
    CSB-PA013069LB01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) LRAT Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    LRAT
  • 別名:
    LRAT; Lecithin retinol acyltransferase; Phosphatidylcholine--retinol O-acyltransferase
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Lecithin retinol acyltransferase protein (24-182AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    HRP
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium; due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology.
  • 基因功能參考文獻:
    1. The genetic analysis performed on our proband showed a novel homozygous mutation on codon 119 of lecithin-cholesterol acyltransferase gene that causes the substitution of glycine by aspartate PMID: 28942093
    2. instability of LRAT(E14L) did not abrogate the production of the visual chromophore in a cell-based assay. Instead, expression of LRAT(E14L) led to a rapid increase in cellular levels of retinoic acid upon retinoid supplementation. PMID: 28758396
    3. LRAT hypermethylation was associated with decreased mRNA levels in colorectal cancer clinical specimens. PMID: 25260806
    4. lecithin retinol acyltransferase affects all-trans retinoic acid levels and has a role in retinoid sensitivity in malignant melanoma cells. PMID: 25236354
    5. These findings reveal structural adaptation that facilitates selective catalysis and mechanism responsible for diverse substrate specificity within the LRAT-like enzyme family PMID: 25383759
    6. high LRAT expression in melanoma might be important in removing retinol as substrate for RA production, thereby inducing signalling pathways leading to dedifferentiation, proliferation and anti-apoptosis PMID: 24433184
    7. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1, that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis. PMID: 23890161
    8. Lecithin-retinol acyltransferase is a thermostable and highly active enzyme with a likely mode of interfacial activation. PMID: 24613493
    9. A genetic defect was identified in LRAT as a novel cause of retinitis punctata albescens. PMID: 22559933
    10. Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT. PMID: 22605381
    11. LRAT mutations cause a severe, early childhood onset, progressive retinal dystrophy. PMID: 22570351
    12. This study showed that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions. PMID: 21465477
    13. Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis. PMID: 19471114
    14. LRAT expression is higher in renal tumors with an indolent biological behavior PMID: 14581364
    15. Conserved residues Cys-161 and His-60 form the essential catalytic dyad of LRAT that represents a novel thiol protease motif, which functions in an acyltransferase reaction. PMID: 14596594
    16. LRAT has a role in preventing progression of invasive bladder cancer PMID: 15161698
    17. Results provide evidence that multiple LRAT mRNA transcripts, which are expressed in a tissue-specific manner, may result from differential splicing of the 5'UTR region and the use of multiple polyadenylation signals in the 3'UTR. PMID: 15474300
    18. LRAT has a role in retinoid absorption and storage PMID: 16115871
    19. These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase. PMID: 16939223
    20. The phenotype of patients with mutations in LRAT is similar to that of patients with mutations in RPE65, suggesting the need to systematically screen both genes in case of typical phenotype. PMID: 17011878
    21. LRAT mutations are likely a rare cause of Leber congenital amaurosis among patients from North America. PMID: 17438524
    22. Lecithin: retinol acyltransferase protein is distributed in both hepatic stellate cells and endothelial cells of normal rodent and human liver. PMID: 18544127
    23. transcriptional regulation is aberrant in human prostate cancer and involves GATA transcription factors in normal prostate epithelial cells PMID: 18652909
    24. proximal region together with basal transcription factors may be sufficient to drive Lrat expression. PMID: 19665987

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Leber congenital amaurosis 14 (LCA14)
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein. Rough endoplasmic reticulum. Endosome, multivesicular body. Cytoplasm, perinuclear region.
  • 蛋白家族:
    H-rev107 family
  • 組織特異性:
    Hepatic stellate cells and endothelial cells (at protein level). Found at high levels in testis and liver, followed by retinal pigment epithelium, small intestine, prostate, pancreas and colon. Low expression observed in brain. In fetal tissues, expressed
  • 數據庫鏈接:

    HGNC: 6685

    OMIM: 604863

    KEGG: hsa:9227

    STRING: 9606.ENSP00000337224

    UniGene: Hs.658427



主站蜘蛛池模板: 久久久国产成人一区二区| 国产超碰人人爽人人做人人添| 99久久久国产精品免费蜜臀| 亚洲人av高清无码| 国产亚洲视频在线观看播放| 国产亚洲精品久久久久久国| 亚洲一区二区无码影院| 欧美国产日韩a在线视频下载| 国产suv精品一区二区62| 人妻中文字幕乱人伦在线| 成人高潮视频在线观看| 精品国产免费观看久久久| 人妻系列影片无码专区| 国产熟人av一二三区| 国精产品一二三区传媒公司| 国产精品白浆在线观看免费| 日本高清在线天码一区播放| 午夜福利视频1692| 草草地址线路①屁屁影院成人| 天堂а√在线中文在线| 欧美成人va免费大片视频| 国产精品麻豆aⅴ人妻| 亚洲午夜福利在线视频| 人人妻人人澡人人爽| 欧洲美熟女乱又伦av影片| 国模国产精品嫩模大尺度视频 | 中文字幕人妻丝袜成熟乱 | 免费无码又爽又刺激毛片| 色综合久久网| 久久99国产综合精品免费| 最新版天堂资源中文官网| 国产精品卡一卡2卡3卡4| 乱人伦人妻精品一区二区| 99国产精品久久久久久久成人| 亚洲综合久久精品无码色欲| 久久精品国自产拍| 免费三级网站| 四虎亚洲欧美成人网站| 国产日韩综合av在线观看一区| 亚洲人成色777777老人头| 国产-第1页-浮力影院|