在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Large proline-rich protein BAG6 (BAG6), partial

Recombinant Human Large proline-rich protein BAG6 (BAG6), partial

  • 中文名稱：
    Recombinant Human Large proline-rich protein BAG6(BAG6),partial
  • 貨號：
    CSB-MP342402HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：
  • 中文名稱：
    Recombinant Human Large proline-rich protein BAG6(BAG6),partial
  • 貨號：
    CSB-EP342402HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Name:BAG6 Synonyms:BAT3, G3
  • Uniprot No.：
  • 別名：
    2410045D21Rik; AA408914; BAG 6; BAG family molecular chaperone regulator 6; BAG-6; BAG6; BAG6_HUMAN; BAT 3; BAT3; BCL2-associated athanogene 6; D17H6S52E; D6S52E; G3; HLA B associated transcript 3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; large proline rich protein BAG6; Large proline rich protein BAT3; Large proline-rich protein BAG6; large proline-rich protein BAT3; Protein G3; Protein Scythe; Scythe; Scythe; homolog of Xenopus
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    ATP-independent molecular chaperone preventing the aggregation of misfolded and hydrophobic patches-containing proteins. Functions as part of a cytosolic protein quality control complex, the BAG6/BAT3 complex, which maintains these client proteins in a soluble state and participates in their proper delivery to the endoplasmic reticulum or alternatively can promote their sorting to the proteasome where they undergo degradation. The BAG6/BAT3 complex is involved in the post-translational delivery of tail-anchored/type II transmembrane proteins to the endoplasmic reticulum membrane. Recruited to ribosomes, it interacts with the transmembrane region of newly synthesized tail-anchored proteins and together with SGTA and ASNA1 mediates their delivery to the endoplasmic reticulum. Client proteins that cannot be properly delivered to the endoplasmic reticulum are ubiquitinated by RNF126, an E3 ubiquitin-protein ligase associated with BAG6 and are sorted to the proteasome. SGTA which prevents the recruitment of RNF126 to BAG6 may negatively regulate the ubiquitination and the proteasomal degradation of client proteins. Similarly, the BAG6/BAT3 complex also functions as a sorting platform for proteins of the secretory pathway that are mislocalized to the cytosol either delivering them to the proteasome for degradation or to the endoplasmic reticulum. The BAG6/BAT3 complex also plays a role in the endoplasmic reticulum-associated degradation (ERAD), a quality control mechanism that eliminates unwanted proteins of the endoplasmic reticulum through their retrotranslocation to the cytosol and their targeting to the proteasome. It maintains these retrotranslocated proteins in an unfolded yet soluble state condition in the cytosol to ensure their proper delivery to the proteasome. BAG6 is also required for selective ubiquitin-mediated degradation of defective nascent chain polypeptides by the proteasome. In this context, it may participate in the production of antigenic peptides and play a role in antigen presentation in immune response. BAG6 is also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. BAG6 may ensure the proper degradation of these proteins and thereby protects the endoplasmic reticulum from protein overload upon stress. By inhibiting the polyubiquitination and subsequent proteasomal degradation of HSPA2 it may also play a role in the assembly of the synaptonemal complex during spermatogenesis. Also positively regulates apoptosis by interacting with and stabilizing the proapoptotic factor AIFM1. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway.; Involved in DNA damage-induced apoptosis: following DNA damage, accumulates in the nucleus and forms a complex with p300/EP300, enhancing p300/EP300-mediated p53/TP53 acetylation leading to increase p53/TP53 transcriptional activity. When nuclear, may also act as a component of some chromatin regulator complex that regulates histone 3 'Lys-4' dimethylation (H3K4me2).; Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).; Mediates ricin-induced apoptosis.
  • 基因功能參考文獻：
    1. The observations suggest a mechanism whereby the BAG6 ubiquitin-linked domain provides a platform for discriminating substrates with shorter hydrophobicity stretches as a signal for defective proteins. PMID: 26663859
    2. BAG6 co-localizes with HSPA2 in huinan testicular germ cells and epididymal spermatozoa, moving from the equator to the anterior head during capacitation and stably interacting with HSPA2. In zona pellucida binding defect infertility, BAG6 is lacking. PMID: 26153132
    3. we found BAG6 to be dispensable in antigen processing PMID: 26598275
    4. VNTR in the coding region of the FAM46A gene, FAM46A rs11040 SNP and BAG6 rs3117582 SNP are associated with susceptibility to tuberculosis PMID: 24625963
    5. BAG6 rs3117582 SNP was associated with non small cell lung cancer in the Norwegian subjects and the combined Croatian-Norwegian subjects corroborating the earlier finding that BAG6 rs3117582 SNP was associated with lung cancer in Europeans. PMID: 25884493
    6. Data show that molecular chaperone BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA protein (SGTA_NT). PMID: 25415308
    7. This meta-analysis suggested that HLA-B-associated transcript 3 polymorphisms are risk factors for lung cancer. PMID: 25430685
    8. Both TRC35 and Ubl4A have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex. PMID: 25535373
    9. Exogenous BAG6 perturbs the function of the BAG6 complex at a stage subsequent to substrate recognition and polyubiquitylation, most likely the BAG6-dependent delivery of OpD to the proteasome. PMID: 24806960
    10. Susceptibility to large-joint osteoarthritis (hip and knee) is associated with BAG6 rs3117582 SNP and the VNTR polymorphism in the second exon of the FAM46A gene on chromosome 6. PMID: 25231575
    11. Tim-3/Gal-9 interaction favors apoptosis of MBP-specific T lymphocytes in benign multiple sclerosis; this process is reduced in PPMS by the up-regulation of Bat3 PMID: 25091272
    12. show that endogenous dislocation clients are captured specifically in association with the cytosolic chaperone BAG6, or retrieved en masse via their glycan handle PMID: 24594942
    13. This meta-analysis suggested that BAT3 polymorphisms contributed the development of lung cancer. PMID: 24989925
    14. RNF126 is recruited to the N-terminal Ubl domain of Bag6 and preferentially ubiquitinates juxtahydrophobic lysine residues on Bag6-associated clients. PMID: 24981174
    15. Bag6, a protein in the TRC pathway that is also responsible for the degradation of mislocalized proteins, is not only involved in core particle assembly but also has a key role in efficient regulatory particle assembly. PMID: 23900548
    16. we show for the first time that BAG-6(686-936) comprises a subdomain of BAG-6, which is sufficient for receptor docking and inhibition of NKp30-dependent NK cell cytotoxicity as part of a tumor immune escape mechanism PMID: 24133212
    17. Data indicate that BCL2-associated athanogene 6 (BAG6) appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A and GET4 proteins and resistance to cell killing by DNA-damaging agents. PMID: 23723067
    18. Data indicate that the Bag6-Ubl4A-Trc35 complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD). PMID: 23665563
    19. our results suggest an essential role for AIF and its binding partner Scythe in the pathway leading to apoptotic corpse clearance. PMID: 23077592
    20. SGTA recognizes a noncanonical ubiquitin-like domain in the Bag6-Ubl4A-Trc35 complex to promote endoplasmic reticulum-associated degradation. PMID: 23246001
    21. Aberrant enhancement of YWK-II/APLP2 by nuclear export of Bat3 may play a role in cancer development by inhibiting cell apoptosis. PMID: 22641691
    22. A BAG6/SGTA cycle operates during protein maturation and quality control in the cytosol. PMID: 23129660
    23. Bat3 promotes T cell responses and autoimmunity by repressing Tim-3-mediated cell death and exhaustion. PMID: 22863785
    24. Cell type-specific subcellular expression of BAT3 suggests distinct functions in the cytosol and in the nucleus. PMID: 22558287
    25. These findings identify a novel role for Bat3 in regulating DOT1L function, which plays a critical role in DNA damage response. PMID: 22373577
    26. Data show that cleavage of Scythe by caspase-3 occurs after activation of both the extrinsic (i.e. Fas/APO-1-mediated) and the intrinsic (i.e. staurosporine-induced) apoptosis pathway. PMID: 22285488
    27. BAT3, a cytosolic chaperone, is recruited to the site of dislocation through its interaction with Derlin2. PMID: 22174835
    28. We present a mechanism explaining how parallel IFNgamma-mediated regulation of CIITA and of its chaperone BAT3 controls the level of components of the HLA class II processing pathway. PMID: 21940994
    29. Data suggest that BAG-6 is necessary for ubiquitin-mediated degradation of newly synthesized defective polypeptides. PMID: 20713601
    30. Evidence indicates that casp3 activated by ricin acts on BAT3 at the caspase cleavage site, DEQD(1001) to release a C-terminal fragment designated CTF-131, which induces phosphatidylserine exposure, cell rounding, and chromatin condensation as ricin does PMID: 14960581
    31. Interaction of hSGT with Hsc70, Hsp70 or Bag-6/Bat-3/Scythe was demonstrated in prometaphase, thereby suggesting a possible role for complexes containing hSGT and distinct (co)-chaperones during mitosis. PMID: 16777091
    32. MRK phosphorylates Scythe at T1080 in vitro as determined by site-directed mutagenesis and mass spectrometry, supporting the consensus and suggesting Scythe as a physiological substrate for MRK. PMID: 16954377
    33. Bat3 is a novel and essential regulator of p53-mediated responses to genotoxic stress, and that Bat3 controls DNA damage-induced acetylation of p53. PMID: 17403783
    34. HLA-B-associated transcript 3 (BAT3) was released from tumor cells, bound directly to NKp30, and engaged NKp30 on NK cells. BAT3 triggered NKp30-mediated cytotoxicity and was necessary for tumor rejection in a multiple myeloma model. PMID: 18055229
    35. Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis PMID: 18056262
    36. BORIS acts as a platform upon which BAT3 and SET1A assemble and exert effects upon chromatin structure and gene expression. PMID: 18765639
    37. NKp30-mediated NK cells/dendritic cells cross talk resulting either in iDC killing or maturation was BAT3-dependent PMID: 18852879
    38. colocalization of PBF and Scythe/BAT3 in the nucleus might be an important factor for survival of osteosarcoma cells. PMID: 19018758
    39. The HSP70-driven degradation of BAG6, following the BAG6-dependent accumulation of HSP70, could allow the protein-refolding activity of HSP70 and limit the extent of its induction. PMID: 19357808
    40. occurrence of an unusual TG 3' splice site in intron 6 PMID: 17672918

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytosol. Nucleus. Secreted, extracellular exosome.
  • 組織特異性：
    Expressed by immature dendritic cells (at protein level).
  • 數據庫鏈接：

    HGNC: 13919

    OMIM: 142590

    KEGG: hsa:7917

    STRING: 9606.ENSP00000365131

    UniGene: Hs.440900



主站蜘蛛池模板： 国产精品成人久久电影| 国内a∨免费播放| 人妻中文字幕av无码专区| 亚洲欧美日韩久久一区二区| 国产成+人+综合+亚洲 欧美| 久久国产乱子伦精品免费台湾| 国产亚洲精久久久久久无码苍井空| 免费夜色污私人影院在线观看| 亚洲中文字幕久久精品无码va | 乱中年女人伦av一区二区| 国产av亚洲精品ai换脸电影| 中文字幕制服丝袜人妻动态图| 精品国产人成亚洲区| 97影院在线午夜| 欧美一性一乱一交一免费视频 | 人人爽人人澡人人高潮| 成人做受视频试看120秒| 国产1卡2卡三卡四卡精品| 国产精品51麻豆cm传媒| 亚洲 精品 制服 校园 无码| 992tv精品视频tv在线观看| 国产精品成人一区二区三区| 欧美激情日韩精品久久久| 日产乱码一区二区三区在线| 在线观看片免费人成视频无码| 国产二级一片内射视频插放| 大肉大捧一进一出好爽app| 国产乱人伦偷精品视频aaa| 亚洲国产三级在线观看| 久久这里只有精品18| 精品久久久久中文字幕加勒比 | 永久免费无码国产| 亚洲 欧美 国产 动漫 综合| 性生交大片免费看女人按摩| 日本丰满妇人成熟免费中文字幕| 国产精品成人观看视频| 妺妺窝人体色www看人体| 日韩免费无码一区二区视频| 看国产一毛片在线看手机看| 久久婷婷成人综合色| 欧美丰满熟妇xxxxx|