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  4. Recombinant Human Laminin subunit gamma-3 (LAMC3), partial

Recombinant Human Laminin subunit gamma-3 (LAMC3), partial

  • 中文名稱：
    人LAMC3重組蛋白
  • 貨號：
    CSB-YP896551HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人LAMC3重組蛋白
  • 貨號：
    CSB-EP896551HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人LAMC3重組蛋白
  • 貨號：
    CSB-EP896551HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人LAMC3重組蛋白
  • 貨號：
    CSB-BP896551HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人LAMC3重組蛋白
  • 貨號：
    CSB-MP896551HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    LAMA 1; LAMA; LAMA1; LAMB1; Lamc3; LAMC3_HUMAN; Laminin A chain ; Laminin alpha 1; Laminin alpha 1 chain; Laminin B1 chain ; Laminin subunit beta 1; Laminin subunit gamma-3; Laminin-12 subunit gamma; Laminin-14 subunit gamma; Laminin-15 subunit gamma
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.
  • 基因功能參考文獻：
    1. LAMC3 gene variation is associated with oral cavity and pharyngeal cancer. PMID: 27749845
    2. We found statistically significant association with AAO for three genes (WRN, NTN4 and LAMC3) with common associated variants. PMID: 26394601
    3. These data suggest that beta2 and gamma3-containing laminins play an important dose-dependent role in development of the cortical pial basement membrane PMID: 22961762
    4. Recessive LAMC3 mutations cause malformations of occipital cortical development. PMID: 21572413
    5. Laminin isoforms containing the gamma3 chain are unable to bind to integrins due to the absence of the glutamic acid residue conserved in the C-terminal regions of the gamma1 and gamma2 chains PMID: 18697739

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  • 相關疾病：
    Cortical malformations occipital (OCCM)
  • 亞細胞定位：
    Secreted, extracellular space, extracellular matrix, basement membrane.
  • 組織特異性：
    Broadly expressed in: skin, heart, lung, and the reproductive tracts.
  • 數據庫鏈接：

    HGNC: 6494

    OMIM: 604349

    KEGG: hsa:10319

    STRING: 9606.ENSP00000354360

    UniGene: Hs.201805



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