在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human La-related protein 6 (LARP6)

  • 中文名稱:
    人LARP6重組蛋白
  • 貨號:
    CSB-YP887112HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人LARP6重組蛋白
  • 貨號:
    CSB-EP887112HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人LARP6重組蛋白
  • 貨號:
    CSB-BP887112HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人LARP6重組蛋白
  • 貨號:
    CSB-MP887112HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    LARP6
  • Uniprot No.:
  • 別名:
    Acheron; Achn; FLJ11196; La ribonucleoprotein domain family member 6; La-related protein 6; LARP6; LARP6_HUMAN
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-491
  • 氨基酸序列
    AQSGGEARP GPKTAVQIRV AIQEAEDVDE LEDEEEGAET RGAGDPARYL SPGWGSASEE EPSRGHSGTT ASGGENERED LEQEWKPPDE ELIKKLVDQI EFYFSDENLE KDAFLLKHVR RNKLGYVSVK LLTSFKKVKH LTRDWRTTAH ALKYSVVLEL NEDHRKVRRT TPVPLFPNEN LPSKMLLVYD LYLSPKLWAL ATPQKNGRVQ EKVMEHLLKL FGTFGVISSV RILKPGRELP PDIRRISSRY SQVGTQECAI VEFEEVEAAI KAHEFMITES QGKENMKAVL IGMKPPKKKP AKDKNHDEEP TASIHLNKSL NKRVEELQYM GDESSANSSS DPESNPTSPM AGRRHAATNK LSPSGHQNLF LSPNASPCTS PWSSPLAQRK GVSRKSPLAE EGRLNCSTSP EIFRKCMDYS SDSSVTPSGS PWVRRRRQAE MGTQEKSPGT SPLLSRKMQT ADGLPVGVLR LPRGPDNTRG FHGHERSRAC V
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Regulates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs through high-affinity binding of a stem-loop structure in their 5' UTR. This regulation requires VIM and MYH10 filaments, and the helicase DHX9.
  • 基因功能參考文獻:
    1. Study shows that mTORC1 phosphorylates La ribonucleoprotein domain family, member 6 to stimulate type I collagen expression. PMID: 28112218
    2. A cytoplasmic isoform of La protein as well as LARPs 6, 4, and 1 function in mRNA metabolism and translation in distinct but similar ways, sometimes with the poly(A)-binding protein, and in some cases by direct binding to poly(A)-RNA. PMID: 28782243
    3. Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen PMID: 26932461
    4. We postulate that collagen mRNAs directly partition to the endoplasmic reticulum membrane prior to synthesis of the signal peptide and that LARP6 and nonmuscle myosin filaments mediate this process. PMID: 25271881
    5. Data indicate that LA motif protein LARP6 binding to spliced leader RNA (5'SL) of collagen alpha2(I) mRNA is more stable than the binding to 5'SL of alpha1(I) mRNA. PMID: 25692237
    6. The study presents the structure of the La motif and RRM1 of human LARP6 uncovering in both cases considerable structural variation in comparison to the equivalent domains in La and revealing an unprecedented fold for the RRM1. PMID: 25488812
    7. LARP6 is a critical mediator by which IGF-1 augments synthesis of collagen type I in vascular smooth muscle PMID: 24469459
    8. The results demonstrate that the La modules of the human LARP6 is also active in tRNA-mediated suppression, even in the absence of stable UUU-3'OH trailer protection. PMID: 23887937
    9. Acheron regulates vascular endothelial proliferation and angiogenesis together with Id1 during wound healing. PMID: 22139627
    10. Achn enhances human breast tumor growth and vascularization and that this activity is dependent on nuclear localization. PMID: 21387291
    11. LARP6 has a distinctive bipartite RNA binding domain not found in other members of the La superfamily. LARP6 interacts with the two single-stranded regions of the 5' stem-loop. PMID: 19917293
    12. Acheron may influence differentiation in part via its control of cell adhesion dynamics. PMID: 19889961
    13. These data define Achn as a newly discovered regulatory molecule that presumably mediates a variety of developmental and homeostatic processes in animals. PMID: 17383118

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Note=Shuttles between the nucleus and the cytoplasm.
  • 組織特異性:
    Expressed in numerous tissues.
  • 數據庫鏈接:

    HGNC: 24012

    OMIM: 611300

    KEGG: hsa:55323

    STRING: 9606.ENSP00000299213

    UniGene: Hs.416755



主站蜘蛛池模板: 亚洲精品日韩一区二区电影| 亚洲一卡2卡3卡4卡 精品| 欧美gv在线观看| 欧洲免费无线码在线一区| 国产精品青青在线观看爽| 美女又大又黄www免费网站| 国精产品一区一区三区免费视频| 日韩av无码免费播放| 成在线人免费视频| 久久99精品久久久久婷婷暖| 精品一卡二卡三卡四卡网站| 超碰成人人人做人人爽| 国产日韩欧美一区二区东京热| 国产亚洲精品无码成人| 久久久老熟女一区二区三区| 亚洲2021av天堂手机版| 亚洲日韩中文字幕久热| 99久久精品视香蕉蕉| 国产成人无码区免费网站| 小sao货水好多真紧h无码视频 | 正在播放酒店约少妇高潮| 国产综合久久久久久鬼色| 精品久久久久久久久久久aⅴ| 婷婷色香合缴缴情av第三区| 黑人强伦姧人妻久久| 精品一品国产午夜福利视频| 国产freexxxx性播放麻豆| 女人被狂躁到高潮视频免费软件| 无码人妻丰满熟妇区五十路在线| 国产网曝门亚洲综合在线| 久久久久成人片免费观看蜜芽| 私人毛片免费高清影视院| 欧美人与禽猛交狂配| 欧美 日产 国产在线观看| 麻豆国产av丝袜白领传媒| 女人被黑人狂躁c到高潮小说| 中文字幕在线观看| 美女黄频视频大全免费的国内| 亚洲丰满熟妇在线播放电影全集| 国产精品亚洲一区二区三区在线| 欧美黑人欧美精品刺激|